Zobrazeno 1 - 10
of 1 428
pro vyhledávání: '"Ras Signaling"'
Autor:
Masahiro Ueki, Shinsuke Hirabayashi, Yoshitaka Honda, Shunichiro Takezaki, Hiroki Ohata, Shimaa Said Mohamed Ali Abdrabou, Saori Sawai, Yukayo Terashita, Yuko Cho, Hideki Muramatsu, Kazushi Izawa, Takahiro Yasumi, Yoshiyuki Takahashi, Masafumi Yamada, Atsushi Manabe
Publikováno v:
Immunological Medicine, Pp 1-8 (2024)
X-linked NF-κB essential modulator (NEMO) deficiency is a primary immunodeficiency characterized by combined immunodeficiency and ectodermal dysplasia. Monocytes from the patients demonstrate a severely impaired response to tissue necrosis factor or
Externí odkaz:
https://doaj.org/article/f35d67264e9c4ebcb28f1c167bfcc122
Publikováno v:
Hematology, Vol 29, Iss 1 (2024)
ABSTRACTWe aimed to investigate the role and mechanism of LSP1 in the progression of acute myelogenous leukemia. In this study, we established shLSP1 cell line to analyze the function of LSP1 in AML. We observed high expression of LSP1 in AML patient
Externí odkaz:
https://doaj.org/article/489be69079bb4d2f9d548c22f7b04033
Autor:
M. H. S. Deurloo, S. Eide, E. Turlova, Q. Li, S. Spijker, H.-S. Sun, A. J. A. Groffen, Z.-P. Feng
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract Background Rasal1 is a Ras GTPase-activating protein which contains C2 domains necessary for dynamic membrane association following intracellular calcium elevation. Membrane-bound Rasal1 inactivates Ras signaling through its RasGAP activity,
Externí odkaz:
https://doaj.org/article/2da25e7868e54f789515c275a64871b6
Publikováno v:
Heliyon, Vol 10, Iss 11, Pp e32198- (2024)
Background: Periodontitis (PD) has been acknowledged as a complication associated with type 2 diabetes mellitus (T2DM). However, the precise mechanism through which T2DM fosters the development of PD remains elusive. Our objective is to elucidate the
Externí odkaz:
https://doaj.org/article/bf1fe9b1969c4de6980ffb006bb9efb6
Autor:
Takayuki Honda, Katsutoshi Seto, Satoshi Endo, Akira Takemoto, Kousuke Tanimoto, Masashi Kobayashi, Masatake Kitano, Rie Sakakibara, Takahiro Mitsumura, Hironori Ishibashi, Johji Inazawa, Toshihiro Tanaka, Yasunari Miyazaki, Kenichi Okubo
Publikováno v:
Cancer Medicine, Vol 12, Iss 19, Pp 19406-19413 (2023)
Abstract Background The recurrence rate of non‐small cell lung cancer (NSCLC) is as high as 30%, even in the cancer with pathological stage I disease. Therefore, identifying factors predictive of high‐risk pathological recurrence is important. Ho
Externí odkaz:
https://doaj.org/article/6ba7b431ba7f44a4957e152056f0c6c6
Autor:
Farzana Jasmine, Briseis Aschebrook-Kilfoy, Mohammad M. Rahman, Garrett Zaagman, Raymon H. Grogan, Mohammed Kamal, Habibul Ahsan, Muhammad G. Kibriya
Publikováno v:
Current Oncology, Vol 30, Iss 3, Pp 2978-2996 (2023)
The BRAF V600E mutation and DNA promoter methylation play important roles in the pathogenesis of thyroid cancer (TC). However, the association of these genetic and epigenetic alterations is not clear. In this study, using paired tumor and surrounding
Externí odkaz:
https://doaj.org/article/a8f62edc747942d3ac147c4c825861a7
Autor:
K Sriram
Publikováno v:
FEBS Open Bio, Vol 12, Iss 10, Pp 1700-1716 (2022)
Recent biochemical experiments have indicated that in Candida albicans, a commensal fungal pathogen, the Ras signaling pathway plays a significant role in the yeast‐to‐hyphal transition; specifically, two enzymes in this pathway, Adenyl Cyclase C
Externí odkaz:
https://doaj.org/article/fd0f19ea790f46d098337fd9354cfb8b
Akademický článek
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Autor:
Eunus S. Ali, Shamima Akter, Sarker Ramproshad, Banani Mondal, Thoufiqul Alam Riaz, Muhammad Torequl Islam, Ishaq N. Khan, Anca Oana Docea, Daniela Calina, Javad Sharifi-Rad, William C. Cho
Publikováno v:
Cancer Cell International, Vol 22, Iss 1, Pp 1-15 (2022)
Abstract MAPK (mitogen-activated protein kinase) or ERK (extracellular-signal-regulated kinase) pathway is an important link in the transition from extracellular signals to intracellular responses. Because of genetic and epigenetic changes, signaling
Externí odkaz:
https://doaj.org/article/885537f8173b432793c048e9c0255865