Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Ras, rat sarcoma"'
Autor:
Leon P. Loevenich, Thomas Engleitner, Marlies Michl, Sebastian Vosberg, Matjaz Rokavec, Andreas Jung, Heiko Hermeking, Philipp A. Greif, Jens Neumann, Jörg Kumbrink, Roland Rad, Thomas Kirchner, Peter Jung, Rupert Öllinger, Sophie L. Boos
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 517-540 (2022)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Patient-derived tumor organoids recapitulate the characteristics of colorectal cancer (CRC) and provide an ideal platform for preclinical evaluation of personalized treatment options. We aimed to model the acquisition of chemotolera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230937cfbfdbfc2312a8988f38a35f08
http://www.sciencedirect.com/science/article/pii/S2352345X21002228
http://www.sciencedirect.com/science/article/pii/S2352345X21002228
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 750-762 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
The protein tyrosine phosphatase Src homology phosphotyrosyl phosphatase 2 (SHP2) is implicated in various cancers, and targeting SHP2 has become a promising therapeutic approach. We herein described a robust cross-validation high-throughput screenin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::114cd1e4de1acb4de79002f71ffaa0be
https://doi.org/10.1016/j.apsb.2020.10.021
https://doi.org/10.1016/j.apsb.2020.10.021
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 491-506 (2020)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Wnt/β-catenin and phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin complex 1 (PI3K/AKT/mTORC1) pathways both are critically involved in colorectal cancer (CRC) development, although they are implicated in the modulation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c7a306ac692719a8347e0c547725351
http://www.sciencedirect.com/science/article/pii/S2352345X20300515
http://www.sciencedirect.com/science/article/pii/S2352345X20300515
Autor:
Johanna McChord, Katharina Ganss, Christian Krautz, Sebastian Hempel, Klaus-Peter Knoch, Michele Solimena, Robert Grützmann, Philippe Ravassard, Kamal Chowdhury, Jürgen Weitz, Stephan Kersting, Christian Pilarsky, Hassan Mziaut, Steffen Wolk, Georg Henniger
Publikováno v:
Molecular metabolism
Molecular metabolism, Elsevier, 2020, 31, pp.150-162. ⟨10.1016/j.molmet.2019.11.012⟩
Molecular Metabolism, Vol 31, Iss, Pp 150-162 (2020)
Molecular Metabolism
Mol. Metab. 31, 150-162 (2020)
Molecular metabolism, Elsevier, 2020, 31, pp.150-162. ⟨10.1016/j.molmet.2019.11.012⟩
Molecular Metabolism, Vol 31, Iss, Pp 150-162 (2020)
Molecular Metabolism
Mol. Metab. 31, 150-162 (2020)
Objective MicroRNAs (miRNAs) play an integral role in maintaining beta cell function and identity. Deciphering their targets and precise role, however, remains challenging. In this study, we aimed to identify miRNAs and their downstream targets invol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac233ce670f178447662777e657c669
https://doi.org/10.1016/j.molmet.2019.11.012
https://doi.org/10.1016/j.molmet.2019.11.012
Autor:
Christoph Wittich, Claus A. M. Seidel, Radovan Dvorsky, Soheila Rezaei Adariani, Farhad Bazgir, Ehsan Amin, Mohammad Reza Ahmadian, Neda S. Kazemein Jasemi
Publikováno v:
The Journal of Biological Chemistry
RAS effectors specifically interact with GTP-bound RAS proteins to link extracellular signals to downstream signaling pathways. These interactions rely on two types of domains, called RAS-binding (RB) and RAS association (RA) domains, which share com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c908bf66f01ab88e26b2531338812873
http://europepmc.org/articles/PMC8163975
http://europepmc.org/articles/PMC8163975
Autor:
Ivan Silbern, Henning Urlaub, Reinhard Jahn, Kuan-Ting Pan, Stefan Bonn, Maksims Fiosins, Silvio O. Rizzoli, Eugenio F. Fornasiero
Publikováno v:
Molecular & Cellular Proteomics : MCP
Molecular and Cellular Proteomics
Molecular & cellular proteomics 20, 100061-(2021). doi:10.1016/j.mcpro.2021.100061
Molecular and Cellular Proteomics
Molecular & cellular proteomics 20, 100061-(2021). doi:10.1016/j.mcpro.2021.100061
Synaptic transmission is mediated by the regulated exocytosis of synaptic vesicles. When the presynaptic membrane is depolarized by an incoming action potential, voltage-gated calcium channels open, resulting in the influx of calcium ions that trigge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d93635b9e859a1023882c0903a6342
https://pubmed.ncbi.nlm.nih.gov/33582301
https://pubmed.ncbi.nlm.nih.gov/33582301
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 1, Pp 13-29 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 1, Pp 13-29 (2021)
Src homology containing protein tyrosine phosphatase 2 (SHP2) represents a noteworthy target for various diseases, serving as a well-known oncogenic phosphatase in cancers. As a result of the low cell permeability and poor bioavailability, the tradit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::377d61b2602a59fd7130cd6ded70715c
https://pubmed.ncbi.nlm.nih.gov/33532178
https://pubmed.ncbi.nlm.nih.gov/33532178
Autor:
Gilbert J. Cote, Nguyet Minh Hoang, Oorvashi Roy Puli, Marie Claude Hofmann, Heather E. Danysh, Elena McBeath, Brian P. Danysh, Maria E. Cabanillas, Deepankar K. Sinha, Reid T. Powell
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 11, Pp 1121-1134 (2018)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
The ETS family of transcription factors is involved in several normal remodeling events and pathological processes including tumor progression. ETS transcription factors are divided into subfamilies based on the sequence and location of the ETS domai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca0dc81b99cd04b707e47e050584981
http://www.sciencedirect.com/science/article/pii/S1476558618304299
http://www.sciencedirect.com/science/article/pii/S1476558618304299
Publikováno v:
Translational Oncology, Vol 14, Iss 7, Pp 101089-(2021)
Translational Oncology
Translational Oncology
Highlights • Diabetes mellitus and hyperglycemia significantly affect the incidence and prognosis of colorectal cancer. • Evidence of the effects of metformin remain controversial in cancer prognosis. • Potential molecular mechanisms by which D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b748b9c71d9b30a48c845ddaf0de4297
https://doi.org/10.1016/j.tranon.2021.101089
https://doi.org/10.1016/j.tranon.2021.101089
Autor:
Annika Höhn, Daniela Weber, Tobias Jung, Christiane Ott, Martin Hugo, Bastian Kochlik, Richard Kehm, Jeannette König, Tilman Grune, José Pedro Castro
Publikováno v:
Redox Biology, 11: 482-501
Redox Biology
Redox Biology, Vol 11, Iss, Pp 482-501 (2017)
Redox Biology
Redox Biology, Vol 11, Iss, Pp 482-501 (2017)
Aging is a complex phenomenon and its impact is becoming more relevant due to the rising life expectancy and because aging itself is the basis for the development of age-related diseases such as cancer, neurodegenerative diseases and type 2 diabetes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::13c87b488911ba6dca317e83859f0380