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pro vyhledávání: '"Raquel de Pablo-Latorre"'
Autor:
Cristiana Castaldo, Silvia Ciambellotti, Raquel de Pablo-Latorre, Daniela Lalli, Valentina Porcari, Paola Turano
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71657 (2013)
Recombinant human Glutaminyl Cyclase expressed in E. coli is produced as inclusion bodies. Lack of glycosylation is the main origin of its accumulation in insoluble aggregates. Mutation of single isolated hydrophobic amino acids into negative amino a
Externí odkaz:
https://doaj.org/article/08b72f1f483a4db7a361c7e1338f8eac
Autor:
Raquel de Pablo-Latorre, Elena V. Polishhuck, Edoardo Nusco, Assunta Saide, Alessandro Fraldi, Andrea Ballabio
Publikováno v:
Human Molecular Genetics
Human Molecular Genetics; Vol 21
Human Molecular Genetics; Vol 21
Dysfunctional mitochondria are a well-known disease hallmark. The accumulation of aberrant mitochondria can alter cell homeostasis, thus resulting in tissue degeneration. Lysosomal storage disorders (LSDs) are a group of inherited diseases characteri