Continuous treatment with abemaciclib leads to sustained and efficient inhibition of breast cancer cell proliferation

Autor: Raquel, Torres-Guzmán, Maria Patricia, Ganado, Cecilia, Mur, Carlos, Marugan, Carmen, Baquero, Yanzhu, Yang, Yi, Zeng, Huimin, Bian, Jian, Du, Alfonso, de Dios, Oscar, Puig, María José, Lallena

Publikováno v: Oncotarget. 13:864-875

Abemaciclib is an oral, selective cyclin-dependent kinase 46 inhibitor (CDK46i), approved for hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC) as monotherapy for endocrine refract

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69dab28f3ef5a47efbcef09588aa74ec
https://doi.org/10.18632/oncotarget.28249

Preclinical characterization of abemaciclib in hormone receptor positive breast cancer

Autor: Bruna Calsina, Richard P. Beckmann, Raquel Torres-Guzmán, Maria Jose Lallena, Joaquín Amat, Alfonso De Dios, Beatriz Alvarez, Ann M. McNulty, Ana Hermoso, Karsten Boehnke, Sean Buchanan, Jian Du, Xueqian Gong, Carmen Baquero

Publikováno v: Oncotarget

Abemaciclib is an ATP-competitive, reversible kinase inhibitor selective for CDK4 and CDK6 that has shown antitumor activity as a single agent in hormone receptor positive (HR+) metastatic breast cancer in clinical trials. Here, we examined the mecha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a9fd43c0c9825257ec82a6a57e8fb4
https://doi.org/10.18632/oncotarget.17778

Abstract 4850: Targeting prostate cancer with the CDK4 and CDK6 inhibitor abemaciclib

Autor: Jian Du, Carlos Marugán, Raquel Torres-Guzmán, Maria Patricia Ganado, Huimin Bian, Maria Jose Lallena, Carmen Baquero, Ramón Rama, Yi Zeng

Publikováno v: Cancer Research. 80:4850-4850

Background: Prostate cancer (PCa) is a leading cause of cancer death in men and represents a substantial public health burden [1]. Most PCa are primarily dependent on androgen receptor (AR) activity and castration is an effective approach to treat PC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8d03bbdd69e7eb08cd4344f4a0e0b7f
https://doi.org/10.1158/1538-7445.am2020-4850

Overexpression of penicillin V acylase from streptomyces lavendulae and elucidation of its catalytic residues

Autor: Carmen Acebal, Daniel Hormigo, Isabel de la Mata, Jesús Torres-Bacete, José Luis García, M. P. Castillon, Miguel Arroyo, Raquel Torres-Guzmán

Publikováno v: ABACUS. Repositorio de Producción Científica
Universidad Europea (UEM)
E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid
E-Prints Complutense. Archivo Institucional de la UCM
instname

The pva gene from Streptomyces lavendulae ATCC 13664, encoding a novel penicillin V acylase ( Sl PVA), has been isolated and characterized. The gene encodes an inactive precursor protein containing a secretion signal peptide that is activated by two

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb496e336c24b80d18706da9b3390a9
http://hdl.handle.net/11268/4436

Substrate Specificity of Penicillin Acylase from Streptomyces lavendulae

Autor: Carmen Acebal, Isabel de la Mata, Jesús Torres-Bacete, M. P. Castillon, Miguel Arroyo, Raquel Torres-Guzmán

Publikováno v: Biochemical and Biophysical Research Communications. 291:593-597

The kinetic parameters of several substrates of penicillin acylase from Streptomyces lavendulae have been determined. The enzyme hydrolyses phenoxymethyl penicillin (penicillin V) and other penicillins with aliphatic acyl-chains such as penicillin F,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384131cef80845e858bf25f7d045a987
https://doi.org/10.1006/bbrc.2002.6485