Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Raquel Rouco"'
A gene desert required for regulatory control of pleiotropic Shox2 expression and embryonic survival
Autor:
Samuel Abassah-Oppong, Matteo Zoia, Brandon J. Mannion, Raquel Rouco, Virginie Tissières, Cailyn H. Spurrell, Virginia Roland, Fabrice Darbellay, Anja Itum, Julie Gamart, Tabitha A. Festa-Daroux, Carly S. Sullivan, Michael Kosicki, Eddie Rodríguez-Carballo, Yoko Fukuda-Yuzawa, Riana D. Hunter, Catherine S. Novak, Ingrid Plajzer-Frick, Stella Tran, Jennifer A. Akiyama, Diane E. Dickel, Javier Lopez-Rios, Iros Barozzi, Guillaume Andrey, Axel Visel, Len A. Pennacchio, John Cobb, Marco Osterwalder
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Approximately a quarter of the human genome consists of gene deserts, large regions devoid of genes often located adjacent to developmental genes and thought to contribute to their regulation. However, defining the regulatory functions embed
Externí odkaz:
https://doaj.org/article/ea97ba56f1764b518e534e1063bf2e68
Autor:
Raquel Rouco, Olimpia Bompadre, Antonella Rauseo, Olivier Fazio, Rodrigue Peraldi, Fabrizio Thorel, Guillaume Andrey
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Developmental genes are frequently controlled by multiple enhancers sharing similar specificities, so deletions of such regulatory elements often fail to reveal their full function. Here the authors use the Pitx1 testbed locus to characterize the reg
Externí odkaz:
https://doaj.org/article/0b815c21fe024b74b873bddc50a6f53e
Autor:
Hasan Asfour, Estelle Hirsinger, Raquel Rouco, Faouzi Zarrouki, Shinichiro Hayashi, Sandra Swist, Thomas Braun, Ketan Patel, Frédéric Relaix, Guillaume Andrey, Sigmar Stricker, Delphine Duprez, Amalia Stantzou, Helge Amthor
Publikováno v:
Development.
The mechanism of pattern formation during limb muscle development remains poorly understood. The canonical view holds that naïve limb muscle progenitor cells (MPCs) invade a pre-established pattern of muscle connective tissue, thereby forming indivi
Autor:
María, Tiana, Elena, Lopez-Jimenez, Julio Sainz, de Aja, Antonio, Barral, Jesus, Victorino, Claudio, Badia-Careaga, Isabel, Rollan, Raquel, Rouco, Elisa, Santos, Hector, Sanchez-Iranzo, Rafael D, Acemel, Carlos, Torroja, Javier, Adan, Eduardo, Andres-Leon, Jose Luis, Gomez-Skarmeta, Giovanna, Giovinazzo, Fatima, Sanchez-Cabo, Miguel, Manzanares
Publikováno v:
Science advances. 8(28)
Pluripotent cells are a transient population of the mammalian embryo dependent on transcription factors, such as OCT4 and NANOG, which maintain pluripotency while suppressing lineage specification. However, these factors are also expressed during ear
Autor:
José Luis Gómez-Skarmeta, Elena López-Jiménez, Fátima Sánchez-Cabo, Héctor Sánchez-Iranzo, Jesus Victorino, Julio Sainz de Aja, Miguel Manzanares, Isabel Rollan, Antonio Barral, Javier Adan, Elisa Santos, Eduardo Andres-Leon, Maria Tiana, Giovanna Giovinazzo, Carlos Torroja, Rafael D. Acemel, Claudio Badia-Careaga, Raquel Rouco
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Science Advances, 8 (28), 1-13
instname
Science Advances, 8 (28), 1-13
Pluripotent cells are a transient population of the mammalian embryo dependent on transcription factors, such as OCT4 and NANOG, which maintain pluripotency while suppressing lineage specification. However, these factors are also expressed during ear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d12191f6ce3a66e5888efa38bfa42c8
https://hdl.handle.net/20.500.12105/15648
https://hdl.handle.net/20.500.12105/15648
Cis-regulatory elements control gene expression in time and space and their disruption can lead to pathologies. Reporter assays allow the functional validation of enhancers and other regulatory elements, and such assays by means of the generation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed9a3e19be7a77cb0529a3e9efa5b224
https://doi.org/10.1101/2021.07.14.452222
https://doi.org/10.1101/2021.07.14.452222
Autor:
Maria Tiana, Ricardo Magni, Raquel Rouco, Miguel Manzanares, Kuljeet Kaur, Sara Cogliati, José Antonio Enríquez, Rafael J. Ramirez, Mohammed Saeed, Fátima Sánchez-Cabo, Guadalupe Guerrero-Serna, José Jalife, Alba Alvarez-Franco
Publikováno v:
Repisalud
Instituto de Salud Carlos III (ISCIII)
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Cardiovascular Research
Digital.CSIC. Repositorio Institucional del CSIC
Instituto de Salud Carlos III (ISCIII)
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Cardiovascular Research
Digital.CSIC. Repositorio Institucional del CSIC
This work was supported by the Spanish government (BFU2017-84914-P to M.M.; FPI Fellowship to A.A.-F.; FPU Fellowship to R.R.), and in part by grants to J.J. from the National Heart, Lung and Blood Institute (R01 grant HL122352 NIH/NHLBI), the Leducq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4780d301b6837ad9760401f30a914858
http://hdl.handle.net/20.500.12105/14670
http://hdl.handle.net/20.500.12105/14670
Autor:
Hasan Asfour, Estelle Hirsinger, Raquel Rouco, Faouzi Zarrouki, Arunima Murgai, Shinichiro Hayashi, Sandra Swist, Thomas Braun, Ketan Patel, Fred Relaix, Guillaume Andrey, Delphine Duprez, Sigmar Stricker, Amalia Stantzou, Helge Amthor
Publikováno v:
SSRN Electronic Journal.
Autor:
Alba Alvarez-Franco, Raquel Rouco, Rafael J Ramirez, Guadalupe Guerrero-Serna, Maria Tiana, Sara Cogliati, Kuljeet Kaur, Mohammed Saeed, Ricardo Magni, Jose Antonio Enriquez, Fatima Sanchez-Cabo, José Jalife, Miguel Manzanares
Publikováno v:
Cardiovascular Research
Atrial fibrillation (AF) is a progressive cardiac arrhythmia that increases the risk of hospitalization and adverse cardiovascular events. There is a clear demand for more inclusive and large-scale approaches to understand the molecular drivers respo
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