Human α-synuclein overexpression in mouse serotonin neurons triggers a depressive-like phenotype. Rescue by oligonucleotide therapy

Autor: Lluis Miquel-Rio, Diana Alarcón-Arís, María Torres-López, Valentín Cóppola-Segovia, Rubén Pavia-Collado, Verónica Paz, Esther Ruiz-Bronchal, Leticia Campa, Carme Casal, Andrés Montefeltro, Miquel Vila, Francesc Artigas, Raquel Revilla, Analia Bortolozzi

Publikováno v: Translational Psychiatry, Vol 12, Iss 1, Pp 1-12 (2022)

Abstract Anxiety and depression affect 35–50% of patients with Parkinson’s disease (PD), often precede the onset of motor symptoms, and have a negative impact on their quality of life. Dysfunction of the serotonergic (5-HT) system, which regulate

Externí odkaz: https://doaj.org/article/b96ac20039604ef38d882ae21ef22355

Cinco años de investigación, divulgación y colaboración UCM-MAN a través de los bronces legales béticos del Museo

Autor: Enrique Paredes Martín, Raquel Revilla Hita

Publikováno v: Boletín del Museo Arqueológico Nacional, Vol 38/2019, Pp 299-308 (2019)

Presentamos en estas páginas los principales resultados de cinco años de colaboración entre el Museo Arqueológico Nacional y la Universidad Complutense de Madrid acerca de los bronces legales hispanorromanos (leyes de Salpensa, Malaca y Urso), es

Externí odkaz: https://doaj.org/article/5f427c257d4e4eba95e9bcef190e1923

Intracerebral Administration of a Ligand-ASO Conjugate Selectively Reduces α-Synuclein Accumulation in Monoamine Neurons of Double Mutant Human A30P*A53T*α-Synuclein Transgenic Mice

Autor: Rubén Pavia-Collado, Andrés Montefeltro, Lluís Miquel-Rio, Raquel Revilla, Verónica Paz, María Torres-López, Francesc Artigas, Leticia Campa, Raquel Rodriguez-Aller, Analía Bortolozzi, Valentín Coppola-Segovia, Esther Ruiz-Bronchal, Diana Alarcón-Aris

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 2939, p 2939 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 6
Digital.CSIC. Repositorio Institucional del CSIC
instname

α-Synuclein (α-Syn) protein is involved in the pathogenesis of Parkinson’s disease (PD). Point mutations and multiplications of the α-Syn, which encodes the SNCA gene, are correlated with early-onset PD, therefore the reduction in a-Syn synthesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5505f8e391423c0b85ee19ee2af507b4
http://hdl.handle.net/10261/265690

Selective α-synuclein knockdown in monoamine neurons by intranasal oligonucleotide delivery: potential therapy for parkinson’s disease

Autor: Miquel Vila, Isabel Fariñas, Analía Bortolozzi, Rubén Pavia-Collado, Marina Santos, Albert Ferrés-Coy, M. Rosario Chica, Esther Ruiz-Bronchal, Iria Carballo-Carbajal, Mireia Galofré, Andrés Montefeltro, Diana Alarcón-Arís, Ariadna Recasens, Raquel Revilla, Nicolás Zacchi, Francesc Artigas

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Progressive neuronal death in brainstem nuclei and widespread accumulation of α-synuclein are neuropathological hallmarks of Parkinson’s disease (PD). Reduction of α-synuclein levels is therefore a potential therapy for PD. However, because α-sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a156373ca830e1c1389eabc4d0d8e78a
http://hdl.handle.net/10261/176998

Poster Session II-Tuesday

Autor: Iria Carballo-Carbajal, Andrés Montefeltro, Albert Ferrés-Coy, Jordi Bové, Celine Perier, S. Baena, M C Carmona, M. Rosario Chica, Raquel Revilla, Analía Bortolozzi, Mireia Galofré, M. I. Santos, Ariadna Recasens

Publikováno v: Neuropsychopharmacology. 38:S273-S434

Poster presentado en: ACNP (American College of Neuropsychopharmacology) 52nd Annual Conference, celebrada del 8 al 12 de diciembre de 2013 en Hollywood, Florida (Estados Unidos)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1b63ed2b2d0d4be7489e7b25be8330e
https://doi.org/10.1038/npp.2013.280