Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Raquel Ordoñez"'
Autor:
Luis V. Valcárcel, Edurne San José-Enériz, Raquel Ordoñez, Iñigo Apaolaza, Danel Olaverri-Mendizabal, Naroa Barrena, Ana Valcárcel, Leire Garate, Jesús San Miguel, Antonio Pineda-Lucena, Xabier Agirre, Felipe Prósper, Francisco J. Planes
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The development of computational tools for the systematic prediction of metabolic vulnerabilities of cancer cells constitutes a central question in systems biology. Here, we present gmctool, a freely accessible online tool that allows us to
Externí odkaz:
https://doaj.org/article/c4d4832b44504993870e80bfa11472fa
Autor:
Nerea Berastegui, Marina Ainciburu, Juan P. Romero, Paula Garcia-Olloqui, Ana Alfonso-Pierola, Céline Philippe, Amaia Vilas-Zornoza, Patxi San Martin-Uriz, Raquel Ruiz-Hernández, Ander Abarrategi, Raquel Ordoñez, Diego Alignani, Sarai Sarvide, Laura Castro-Labrador, José M. Lamo-Espinosa, Mikel San-Julian, Tamara Jimenez, Félix López-Cadenas, Sandra Muntion, Fermin Sanchez-Guijo, Antonieta Molero, Maria Julia Montoro, Bárbara Tazón, Guillermo Serrano, Aintzane Diaz-Mazkiaran, Mikel Hernaez, Sofía Huerga, Findlay Bewicke-Copley, Ana Rio-Machin, Matthew T. Maurano, María Díez-Campelo, David Valcarcel, Kevin Rouault-Pierre, David Lara-Astiaso, Teresa Ezponda, Felipe Prosper
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Myelodysplastic syndromes (MDS) are age-related pathologies in which alterations of hematopoietic stem cells lead to abnormal formation of blood cells. Here, the authors study the lesions that these cells undergo in aging and disease, characterizing
Externí odkaz:
https://doaj.org/article/5a52f5ed769d4553afa3673e2f1e7052
Autor:
Jessica M. Halow, Rachel Byron, Megan S. Hogan, Raquel Ordoñez, Mark Groudine, M. A. Bender, John A. Stamatoyannopoulos, Matthew T. Maurano
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The functional consequences of variation in human regulatory DNA depend on the local chromatin environment and the cell/tissue context. Here the authors use highly diverged hybrid mice to study genetic effects on DNA accessibility in vivo across mult
Externí odkaz:
https://doaj.org/article/1d484e6b9c4d452395c7af6a519b4e6c
Autor:
Nicolás Martínez-Calle, Marien Pascual, Raquel Ordoñez, Edurne San José Enériz, Marta Kulis, Estíbaliz Miranda, Elisabeth Guruceaga, Víctor Segura, María José Larráyoz, Beatriz Bellosillo, María José Calasanz, Carles Besses, José Rifón, José I. Martín-Subero, Xabier Agirre, Felipe Prosper
Publikováno v:
Haematologica, Vol 104, Iss 8 (2019)
In this study we interrogated the DNA methylome of myelofibrosis patients using high-density DNA methylation arrays. We detected 35,215 differentially methylated CpG, corresponding to 10,253 genes, between myelofibrosis patients and healthy controls.
Externí odkaz:
https://doaj.org/article/92c068858094471b9449973937dec2fd
Autor:
Andrea Janz Moreira, Raquel Ordoñez, Carlos Thadeu Cerski, Jaqueline Nascimento Picada, Andrés García-Palomo, Norma Possa Marroni, Jose L Mauriz, Javier González-Gallego
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144517 (2015)
Hepatocellular carcinoma (HCC) is one of the most lethal human cancers worldwide because of its high incidence, its metastatic potential and the low efficacy of conventional treatment. Inactivation of apoptosis is implicated in tumour progression and
Externí odkaz:
https://doaj.org/article/2e874509ed494104993d236eef1904ba
Autor:
Marta Larrayoz, Maria J. Garcia-Barchino, Jon Celay, Amaia Etxebeste, Maddalen Jimenez, Cristina Perez, Raquel Ordoñez, Cesar Cobaleda, Cirino Botta, Vicente Fresquet, Sergio Roa, Ibai Goicoechea, Catarina Maia, Miren Lasaga, Marta Chesi, P. Leif Bergsagel, Maria J. Larrayoz, Maria J. Calasanz, Elena Campos-Sanchez, Jorge Martinez-Cano, Carlos Panizo, Paula Rodriguez-Otero, Silvestre Vicent, Giovanna Roncador, Patricia Gonzalez, Satoru Takahashi, Samuel G. Katz, Loren D. Walensky, Shannon M. Ruppert, Elisabeth A. Lasater, Maria Amann, Teresa Lozano, Diana Llopiz, Pablo Sarobe, Juan J. Lasarte, Nuria Planell, David Gomez-Cabrero, Olga Kudryashova, Anna Kurilovich, Maria V. Revuelta, Leandro Cerchietti, Xabier Agirre, Jesus San Miguel, Bruno Paiva, Felipe Prosper, Jose A. Martinez-Climent
The historical lack of preclinical models reflecting the genetic heterogeneity of multiple myeloma (MM) hampers the advance of therapeutic discoveries. To circumvent this limitation, we screened mice engineered to carry eight MM lesions (NF-κB, KRAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2563a745972cadf6c4af5126546113b9
https://hdl.handle.net/10171/65914
https://hdl.handle.net/10171/65914
Autor:
Luis V. Valcárcel, Edurne San José-Enériz, Raquel Ordoñez, Iñigo Apaolaza, Ana Valcárcel, Leire Garate, Jesús San Miguel, Antonio Pineda-Lucena, Xabier Agirre, Felipe Prósper, Francisco J. Planes
The development of computational tools for the systematic prediction of metabolic vulnerabilities of cancer cells constitutes a central question in systems biology. Here, we presentgMCStool, a freely accessible and online tool that allows us to carry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e57e037275954def71706748018a75f4
https://doi.org/10.1101/2022.11.03.514827
https://doi.org/10.1101/2022.11.03.514827
Autor:
Elena Sáez, Musheng Xu, Raquel Ordoñez, Amaia Vilas-Zornoza, Feifei Zhang, Xabier Agirre, Antonio Pineda-Lucena, Obdulia Rabal, Julen Oyarzabal, Felipe Prosper, Edurne San José-Enériz, Estíbaliz Miranda, Irene de Miguel, Leire Garate, Juan A. Sánchez-Arias, Ander Estella, Wei Wu
Publikováno v:
Journal of Medicinal Chemistry. 64:3392-3426
Concomitant inhibition of key epigenetic pathways involved in silencing tumor suppressor genes has been recognized as a promising strategy for cancer therapy. Herein, we report a first-in-class series of quinoline-based analogues that simultaneously
Autor:
Jesús F. San Miguel, Marta Kulis, Elisabeth Guruceaga, Arantxa Carrasco-Leon, Felipe Prosper, Raquel Ordoñez, Ane Amundarain, Leire Garate, Cem Meydan, Teresa Ezponda, Laura Castro-Labrador, Xabier Agirre, José I. Martín-Subero, Ari Melnick, Marien Pascual, Estíbaliz Miranda, Amaia Vilas-Zornoza, Christopher E. Mason, Bruno Paiva, Halima El-Omri, Patxi San Martin-Uriz, Diego Alignani, María José Calasanz, Luis Vitores Valcárcel, Ruba Y. Taha, Francisco J. Planes, Victor Segura
Publikováno v:
Leukemia
Multiple myeloma (MM) is an incurable disease, whose clinical heterogeneity makes its management challenging, highlighting the need for biological features to guide improved therapies. Deregulation of specific long non-coding RNAs (lncRNAs) has been
Autor:
Kathyell Daniela, Rizo Chavarría, Gloria Elena, Martínez Ruiz, Cecilia Raquel, Ordoñez Pinell
La presente investigación aborda el tema de la Implementación de las estrategias de marketing turístico para la maximización de la afluencia turística en el café Los Robles y la Finca Agroturística el Tisey, en la reserva natural el Tisey, la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3634::8318976e5cad625e50df9b4bd0ce21ec
http://repositorio.unan.edu.ni/18066/2/cc.jpg
http://repositorio.unan.edu.ni/18066/2/cc.jpg