Cyclic AMP efflux through MRP4 regulates actin dynamics signalling pathway and sperm motility in bovines

Autor: Marcelo Miragaya, Agustín Yaneff, Carlos A. I. Alonso, Camila Arroyo-Salvo, Jessica Plaza, Claudia Osycka-Salut, Raquel Lottero-Leconte, Nicolás Chiarante, Carlos Davio, Silvina Perez-Martinez

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Previously we demonstrated that multidrug resistance-associated protein 4 transporter (MRP4) mediates cAMP efflux in bovine spermatozoa and that extracellular cAMP (ecAMP) triggers events associated to capacitation. Here, we deepen the study of the r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b654832411316e2397b1655be6d3f88b
https://doi.org/10.1038/s41598-020-72425-5

Involvement of cAMP efflux, through MRP4 transporter, in the acquisition of fertilization ability of mouse spermatozoa

Autor: Maria Gracia Gervasi, Carlos Davio, Mariano G. Buffone, Z J Vernaz, N. Di Siervi, C.A.I. Alonso, Raquel Lottero-Leconte, Guillermina Maria Luque, Silvina Perez-Martinez

Publikováno v: Journal of Cell Science.

Mammalian spermatozoa must undergo biochemical and structural changes to acquire the capacity for fertilization, in a process known as capacitation. Activation of PKA enzymes is essential for capacitation, and thus cAMP levels are tightly regulated d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e0c0e37afb44e09b889bf7acd86216b
https://doi.org/10.1242/jcs.230565