Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Raquel L Lieberman"'
Autor:
Raquel L Lieberman
Publikováno v:
PLoS Biology, Vol 17, Iss 4, p e3000237 (2019)
Over 20 years ago, alterations to the protein myocilin were confirmed to be linked to a heritable form of the prevalent eye disease, glaucoma, and 10 years ago, my lab set out to develop a deeper understanding of myocilin in its normal and diseased s
Externí odkaz:
https://doaj.org/article/7ff0a6df32b342a48de68ba492fc432f
Autor:
Xiaolai Zhou, Daniel H Paushter, Mitchell D Pagan, Dongsung Kim, Mariela Nunez Santos, Raquel L Lieberman, Herman S Overkleeft, Ying Sun, Marcus B Smolka, Fenghua Hu
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0212382 (2019)
Mutation in the GRN gene, encoding the progranulin (PGRN) protein, shows a dose-dependent disease correlation, wherein haploinsufficiency results in frontotemporal lobar degeneration (FTLD) and complete loss results in neuronal ceroid lipofuscinosis
Externí odkaz:
https://doaj.org/article/f702a5e6783641b88e7bf48fd81d95ed
Autor:
Shannon E Hill, Elaine Nguyen, Chiamaka U Ukachukwu, Dana M Freeman, Stephen Quirk, Raquel L Lieberman
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180241 (2017)
Dihydroneopterin triphosphate pyrophosphatase (DHNTPase), a member of the Mg2+ dependent Nudix hydrolase superfamily, is the recently-discovered enzyme that functions in the second step of the pterin branch of the folate biosynthetic pathway in E. co
Externí odkaz:
https://doaj.org/article/5b13bfc4386c424ca8afd8f091ea9b83
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130888 (2015)
Olfactomedin (OLF) domains are found within extracellular, multidomain proteins in numerous tissues of multicellular organisms. Even though these proteins have been implicated in human disorders ranging from cancers to attention deficit disorder to g
Externí odkaz:
https://doaj.org/article/23534b2e809d4d7193a166d9a0c9eaf0
Autor:
Emily G. Saccuzzo, Mubark D. Mebrat, Hailee F. Scelsi, Minjoo Kim, Minh Thu Ma, Xinya Su, Shannon E. Hill, Elisa Rheaume, Renhao Li, Matthew P. Torres, James C. Gumbart, Wade D. Van Horn, Raquel L. Lieberman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Studies of folded-to-misfolded transitions using model protein systems reveal a range of unfolding needed for exposure of amyloid-prone regions for subsequent fibrillization. Here, we probe the relationship between unfolding and aggregation
Externí odkaz:
https://doaj.org/article/d4c43b083a34447bb38dec82f348044d
Autor:
Susan D Orwig, Raquel L Lieberman
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16347 (2011)
Myocilin is an eye protein found in the trabecular extracellular matrix (TEM), within the anatomic region that controls fluid flow. Variants of myocilin, localized to its olfactomedin (OLF) domain, have been linked to inherited forms of glaucoma, a d
Externí odkaz:
https://doaj.org/article/054dd2289ce645edac915e0a51ea4289
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 1 (2023)
Externí odkaz:
https://doaj.org/article/b146bceaf19e4514bbd615537e7e9763
Autor:
Emily G. Saccuzzo, Mackenzie D. Martin, Kamisha R. Hill, Minh Thu Ma, Yemo Ku, Raquel L. Lieberman
Publikováno v:
JBIC Journal of Biological Inorganic Chemistry. 27:553-564
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9742009be06e4356696cad6be4477b10
https://doi.org/10.1007/s00775-022-01946-3
https://doi.org/10.1007/s00775-022-01946-3
Autor:
Nikhil Thota, Stephen Quirk, Yi Zhuang, Erica R. Stover, Raquel L. Lieberman, Rigoberto Hernandez
Publikováno v:
Biophysical Journal.
The actin filament network is in part remodeled by the action of a family of filament severing proteins that are responsible for modulating the ratio between monomeric and filamentous actin. Recent work on the protein actophorin from the amoeba Acant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401878c462a3d23bdc574dfe526cdcdf
https://doi.org/10.1016/j.bpj.2022.11.2941
https://doi.org/10.1016/j.bpj.2022.11.2941
Autor:
Raquel L. Lieberman, Stephen Quirk
Publikováno v:
Acta Crystallogr F Struct Biol Commun
Actophorin, a protein that severs actin filaments isolated from the amoeba Acanthamoeba castellanii, was employed as a test case for crystallization under microgravity. Crystals of purified actophorin were grown under microgravity conditions aboard t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f71fc9f90705c2e3f8ef1873185ec9
https://doi.org/10.1107/s2053230x21011419
https://doi.org/10.1107/s2053230x21011419