Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Raquel L Arribas"'
Autor:
Lucía Viejo, Marcos Rubio-Alarcón, Raquel L. Arribas, Manuel Moreno-Castro, Raquel Pérez-Marín, María Braun-Cornejo, Martín Estrada-Valencia, Cristóbal de los Ríos
Publikováno v:
Molecules, Vol 26, Iss 15, p 4473 (2021)
In excitable cells, mitochondria play a key role in the regulation of the cytosolic Ca2+ levels. A dysregulation of the mitochondrial Ca2+ buffering machinery derives in serious pathologies, where neurodegenerative diseases highlight. Since the mitoc
Externí odkaz:
https://doaj.org/article/9df0f4b8e4fb4447858d66485f9b2489
Autor:
Raquel L. Arribas, Lucía Viejo, Isaac Bravo, Minerva Martínez, Eva Ramos, Alejandro Romero, Eva M. García-Frutos, Veerle Janssens, Carmen Montiel, Cristóbal de los Ríos
Publikováno v:
European Journal of Medicinal Chemistry. 251:115245
La proteína fosfatasa 2A (PP2A) es una importante Ser/Thr fosfatasa que participa en la regulación de múltiples procesos celulares. Esto implica que cualquier actividad deficiente de PP2A es responsable de graves patologías graves. Por ejemplo, u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a4c2dfd3117ec20aeab9dcbf97cd78d
https://doi.org/10.1016/j.ejmech.2023.115245
https://doi.org/10.1016/j.ejmech.2023.115245
Autor:
Raquel Pérez-Marín, María Braun-Cornejo, Manuel Moreno-Castro, Cristóbal de los Ríos, Raquel L Arribas, Marcos Rubio-Alarcón, Martín Estrada-Valencia, Lucía Viejo
Publikováno v:
Molecules
Volume 26
Issue 15
Molecules, Vol 26, Iss 4473, p 4473 (2021)
Volume 26
Issue 15
Molecules, Vol 26, Iss 4473, p 4473 (2021)
In excitable cells, mitochondria play a key role in the regulation of the cytosolic Ca2+ levels. A dysregulation of the mitochondrial Ca2+ buffering machinery derives in serious pathologies, where neurodegenerative diseases highlight. Since the mitoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e201586b80cfb02e6ce6cd330d93738a
Autor:
Javier Egea, Daniel Diez-Iriepa, Barbara Mordyl, Alejandra Palomino-Antolín, Rim Malek, Lhassane Ismaili, Tereza Kobrlova, Justyna Godyń, Ondrej Soukup, José Marco-Contelles, Agata Siwek, Fakher Chabchoub, Ignacio Moraleda, Cristóbal de los Ríos, Dawid Panek, Céline Demougeot, Perle Totoson, Katarzyna Kieć-Kononowicz, Isabel Iriepa, Monika Głuch-Lutwin, Barbara Malawska, Raquel L Arribas
Publikováno v:
Journal of Medicinal Chemistry. 62:11416-11422
New tritarget small molecules combining Ca2+ channels blockade, cholinesterase, and H3 receptor inhibition were obtained by multicomponent synthesis. Compound 3p has been identified as a very promising lead, showing good Ca2+ channels blockade activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30367824b94baa33e4e87aec58b11b2e
https://doi.org/10.1021/acs.jmedchem.9b00937
https://doi.org/10.1021/acs.jmedchem.9b00937
Autor:
Lucía Viejo, Cristóbal de los Ríos, Arzobispo Morcillo, . Madrid, Spain., Diego de León, . Madrid, Spain., Raquel L Arribas
Publikováno v:
IBJ Plus.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8971bc69c136d4edeca4b65227667a0
https://doi.org/10.24217/2531-0151.21v1s4.00030
https://doi.org/10.24217/2531-0151.21v1s4.00030
Autor:
Eva Ramos, Raquel L Arribas, Javier Egea, Cristóbal de los Ríos, Laura González-Lafuente, Eva M. García-Frutos, Rocío Lajarín-Cuesta, Alejandro Romero
Publikováno v:
E-Prints Complutense. Archivo Institucional de la UCM
instname
Chemical Research in Toxicology
instname
Chemical Research in Toxicology
N-Propargylamines are useful synthetic scaffolds for the synthesis of bioactive molecules, and in addition, they possess important pharmacological activities. We obtained several neuroprotective molecules, chiral 1,2-amino alcohols and 1,2-diamines,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3b71afe9ed768944ba0bd5d2cfdf81
https://eprints.ucm.es/id/eprint/69284/1/acs.chemrestox.0c00519.pdf
https://eprints.ucm.es/id/eprint/69284/1/acs.chemrestox.0c00519.pdf
Autor:
Vendula Hepnarova, Kamil Musilek, Aurélie Baguet, Daniel Jun, José Marco-Contelles, Lhassane Ismaili, Emmanuel Haffen, Tomas Kucera, Jan Korabecny, Jana Janockova, Angela De Simone, Eva M. García-Frutos, Vincenza Andrisano, Manuela Bartolini, B. Refouvelet, Lucía Viejo, Cristóbal de los Ríos, Adeline Etievant, Ondrej Soukup, Rudolf Andrys, Julie Monnin, Raquel L Arribas
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Multitarget-directed ligands (MTDLs) are considered a promising therapeutic strategy to address the multifactorial nature of Alzheimer's disease (AD). Novel MTDLs have been designed as inhibitors of human acetylcholinesterases/butyrylcholinesterases,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e6fe64522ccbd8b7235529a49bc67a
http://hdl.handle.net/10261/260260
http://hdl.handle.net/10261/260260
Autor:
Eva M. García-Frutos, Carmen Nanclares, Raquel L Arribas, Luis Gandía, Cristóbal de los Ríos, Rocío Lajarín-Cuesta
Publikováno v:
European Journal of Medicinal Chemistry. 157:294-309
We report the synthesis and pharmacological evaluation of new 3-aminomethylindoles derivatives with neuroprotective properties designed to present multi-target activity centered on reducing the neuronal Ca2+ overload and preventing phosphatase 2A (PP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186db91f78cc584139e16633afd823c6
https://doi.org/10.1016/j.ejmech.2018.07.030
https://doi.org/10.1016/j.ejmech.2018.07.030
Publikováno v:
British Journal of Pharmacology. 175:3220-3229
Melatonin is an endogenous hormone produced by the pineal gland as well as many other tissues and organs. The natural decline in melatonin levels with ageing contributes significantly to the development of neurodegenerative disorders. Neurodegenerati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5dde9c5ed70edc0095d534ef7d53b26
https://doi.org/10.1111/bph.14365
https://doi.org/10.1111/bph.14365
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:2551-2560
Following the premises of the multitarget-directed ligands approach for the drug RD nevertheless that substitution provoked loss of viability at 100-fold higher concentrations (10 μM), what discards them for a deeper pharmacological study. Overall,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06044f81eb15e4301ca15b0f46c17c47
https://doi.org/10.1016/j.bmc.2018.04.019
https://doi.org/10.1016/j.bmc.2018.04.019