Conjugation of the 9-kDa Isoform of Granulysin with Liposomes Potentiates Its Cytotoxicity

Autor: Ruth Soler-Agesta, Patricia Guerrero-Ochoa, Joaquín Marco-Brualla, Raquel Ibáñez-Pérez, Isabel Marzo, Luis Martínez-Lostao, Alberto Anel

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 15, p 8705 (2022)

Nine kDa granulysin (GRNLY) is a human cytolytic protein secreted by cytotoxic T lymphocytes (CTL) and NK cells of the immune system whose demonstrated physiological function is the elimination of bacteria and parasites. In previous studies by our gr

Externí odkaz: https://doaj.org/article/e24e28a51e704b50be266e313485bbe4

Preclinical Studies of Granulysin-Based Anti-MUC1-Tn Immunotoxins as a New Antitumoral Treatment

Autor: Patricia Guerrero-Ochoa, Raquel Ibáñez-Pérez, Germán Berbegal-Pinilla, Diederich Aguilar, Isabel Marzo, Francisco Corzana, Martha Minjárez-Sáenz, Javier Macías-León, Blanca Conde, Javier Raso, Ramón Hurtado-Guerrero, Alberto Anel

Publikováno v: Biomedicines, Vol 10, Iss 6, p 1223 (2022)

Two granulysin (GRNLY) based immunotoxins were generated, one containing the scFv of the SM3 mAb (SM3GRNLY) and the other the scFv of the AR20.5 mAb (AR20.5GRNLY). These mAb recognize different amino acid sequences of aberrantly O-glycosylated MUC1,

Externí odkaz: https://doaj.org/article/3c78f91eec174fcd91fca34c57a58985

Anti-tumoral potential of a human granulysin-based, CEA-targeted cytolytic immunotoxin

Autor: Raquel Ibáñez-Pérez, Patricia Guerrero-Ochoa, Sameer Al-Wasaby, Rocío Navarro, Antonio Tapia-Galisteo, Diego De Miguel, Oscar Gonzalo, Blanca Conde, Luis Martínez-Lostao, Ramón Hurtado-Guerrero, Laura Sanz, Alberto Anel

Publikováno v: OncoImmunology, Vol 8, Iss 11 (2019)

Granulysin is a protein present in the granules of human cytotoxic T lymphocytes (CTL) and natural killer (NK) cells, with cytolytic activity against microbes and tumors. Previous work demonstrated the therapeutic effect of intratumoral injection of

Externí odkaz: https://doaj.org/article/ddae2382868c4a1a8515e30f3143a05f

Preclinical Studies of Granulysin-Based Anti-Tn Immunotoxins as A New Antitumoral Treatment

Autor: Patricia Guerrero-Ochoa, Raquel Ibáñez-Pérez, Germán Berbegal-Pinilla, Diederich Aguilar, Isabel Marzo, Francisco Corzana, Blanca Conde, Javier Raso, Ramón Hurtado-Guerrero, Alberto Anel

Two granulysin (GRNLY) based immunotoxins were generated, one containing the scFv of the SM3 mAb (SM3GRNLY) and the other the scFv of the AR20.5 mAb (AR20.5GRNLY). These mAb recognize different amino acid sequences of aberrantly O-glycosilated MUC1,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3cba3af2545668286283fd4de75d43d

Production of a Granulysin-Based, Tn-Targeted Cytolytic Immunotoxin Using Pulsed Electric Field Technology

Autor: Raquel Ibáñez-Pérez, Javier Raso, Diederich Aguilar-Machado, Ramon Hurtado-Guerrero, Patricia Guerrero-Ochoa, Alberto Anel, Javier Macías-León

Publikováno v: International Journal of Molecular Sciences
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Guerrero-Ochoa, P, Aguilar-Machado, D, Ibáñez-Pérez, R, Macías-León, J, Hurtado-Guerrero, R, Raso, J & Anel, A 2020, ' Production of a granulysin-based, tn-targeted cytolytic immunotoxin using pulsed electric field technology ', International Journal of Molecular Sciences, vol. 21, no. 17, 6165, pp. 1-12 . https://doi.org/10.3390/ijms21176165
Volume 21
Issue 17
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
International Journal of Molecular Sciences, Vol 21, Iss 6165, p 6165 (2020)

Granulysin is a protein present in the granules of human cytotoxic T lymphocytes (CTL) and natural killer (NK) cells, with cytolytic activity against microbes and tumors. Previous work demonstrated the therapeutic effect of the intratumoral injection

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf2f5bd7b71e9f0ebaf03d1f5e6502f
http://europepmc.org/articles/PMC7503585