Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Raquel Gomez-Sintes"'
Autor:
Raquel Gomez-Sintes, Qisheng Xin, Juan Ignacio Jimenez-Loygorri, Mericka McCabe, Antonio Diaz, Thomas P. Garner, Xiomaris M. Cotto-Rios, Yang Wu, Shuxian Dong, Cara A. Reynolds, Bindi Patel, Pedro de la Villa, Fernando Macian, Patricia Boya, Evripidis Gavathiotis, Ana Maria Cuervo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Gomez-Sintes et al. have developed small molecules that selectively activate chaperone-mediated autophagy by stabilizing the interaction between retinoic acid receptor alpha and its co-repressor N-CoR1. They demonstrate the protective effect of boost
Externí odkaz:
https://doaj.org/article/31e22769f6804f2d8f96a489a0f64889
Autor:
Ignacio Ramírez-Pardo, Beatriz Villarejo-Zori, Juan Ignacio Jiménez-Loygorri, Elena Sierra-Filardi, Sandra Alonso-Gil, Guillermo Mariño, Pedro de la Villa, Patrick S Fitze, José Manuel Fuentes, Ramón García-Escudero, Raquel Gomez-Sintes, Patricia Boya
Autophagy is a key process in the maintenance of cellular homeostasis. The age-dependent decline in retinal autophagy has been associated with photoreceptor degeneration. Retinal dysfunction can also result from damage to the retinal pigment epitheli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7578d691d146e7160c4367689cbd1f9a
https://doi.org/10.1101/2022.02.04.476630
https://doi.org/10.1101/2022.02.04.476630
Autor:
Ignacio Ramírez-Pardo, Beatriz Villarejo-Zori, Juan Ignacio Jiménez-Loygorri, Elena Sierra-Filardi, Sandra Alonso-Gil, Guillermo Mariño, Pedro de la Villa, Patrick S Fitze, José Manuel Fuentes, Ramón García-Escudero, Deborah A. Ferrington, Raquel Gomez-Sintes, Patricia Boya
Publikováno v:
Scopus
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
22 p.-9 fig.
Macroautophagy/autophagy is a key process in the maintenance of cellular homeostasis. The age-dependent decline in retinal autophagy has been associated with photoreceptor degeneration. Retinal dysfunction can also result from damag
Macroautophagy/autophagy is a key process in the maintenance of cellular homeostasis. The age-dependent decline in retinal autophagy has been associated with photoreceptor degeneration. Retinal dysfunction can also result from damag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d39e5a0ae225eaae1cc82a7b1f02c2
http://hdl.handle.net/10651/66645
http://hdl.handle.net/10651/66645
Autor:
Esperanza Arias, Raquel Gomez-Sintes
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Mol Aspects Med
instname
Mol Aspects Med
14 p.-3 fig.-1 tab.
Chaperone-mediated autophagy (CMA) is a proteolytic process whereby selected intracellular proteins are degraded inside lysosomes. Owing to its selectivity, CMA participates in the modulation of specific regulatory proteins,
Chaperone-mediated autophagy (CMA) is a proteolytic process whereby selected intracellular proteins are degraded inside lysosomes. Owing to its selectivity, CMA participates in the modulation of specific regulatory proteins,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebdbd090159b694489eaeb698bd5e79f
http://hdl.handle.net/10261/252142
http://hdl.handle.net/10261/252142
Autor:
Raquel Gomez-Sintes, Qisheng Xin, Juan Ignacio Jimenez-Loygorri, Mericka McCabe, Antonio Diaz, Thomas P. Garner, Xiomaris M. Cotto-Rios, Yang Wu, Shuxian Dong, Cara A. Reynolds, Bindi Patel, Pedro de la Villa, Fernando Macian, Patricia Boya, Evripidis Gavathiotis, Ana Maria Cuervo
Publikováno v:
Nature communications. 13(1)
18 p.-8 fig.
Chaperone-mediated autophagy activity, essential in the cellular defense against proteotoxicity, declines with age, and preventing this decline in experimental genetic models has proven beneficial. Here, we have identified the mecha
Chaperone-mediated autophagy activity, essential in the cellular defense against proteotoxicity, declines with age, and preventing this decline in experimental genetic models has proven beneficial. Here, we have identified the mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f45fe1e9e9394a1abf63ab45c7ad87
https://pubmed.ncbi.nlm.nih.gov/35864098
https://pubmed.ncbi.nlm.nih.gov/35864098
Autor:
Ramírez-Pardo, Ignacio, Villarejo-Zori, Beatriz, Jiménez-Loygorri, Juan Ignacio, Sierra-Filardi, Elena, Alonso-Gil, Sandra, Mariño, Guillermo, de la Villa, Pedro, Fitze, Patrick S, Fuentes, José Manuel, García-Escudero, Ramón, Ferrington, Deborah A., Gomez-Sintes, Raquel, Boya, Patricia
Publikováno v:
Autophagy; Mar2023, Vol. 19 Issue 3, p784-804, 21p
Autor:
Gomez-Sintes, Raquel, Xin, Qisheng, Jimenez-Loygorri, Juan Ignacio, McCabe, Mericka, Diaz, Antonio, Garner, Thomas P., Cotto-Rios, Xiomaris M., Wu, Yang, Dong, Shuxian, Reynolds, Cara A., Patel, Bindi, de la Villa, Pedro, Macian, Fernando, Boya, Patricia, Gavathiotis, Evripidis, Cuervo, Ana Maria
Publikováno v:
Nature Communications; 7/21/2022, Vol. 13 Issue 1, p1-18, 18p
Autor:
Klionsky, Daniel J., Abdel-Aziz, Amal Kamal, Abdelfatah, Sara, Abdellatif, Mahmoud, Abdoli, Asghar, Abel, Steffen, Abeliovich, Hagai, Abildgaard, Marie H., Abudu, Yakubu Princely, Acevedo-Arozena, Abraham, Adamopoulos, Iannis E., Adeli, Khosrow, Adolph, Timon E., Adornetto, Annagrazia, Aflaki, Elma, Agam, Galila, Agarwal, Anupam, Aggarwal, Bharat B., Agnello, Maria, Agostinis, Patrizia
Publikováno v:
Autophagy; Jan2021, Vol. 17 Issue 1, p1-382, 382p
Many researchers believe that GSK-3 and its inhibitors could lead to effective treatments for neurogenerative disorders, type II diabetes, depression and bipolar disorder, and some forms of cancer. This book provides a thorough introduction to GSK-3,