Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Raquel Garcı́a-Nieto"'
Autor:
Juan J. Vaquero, Carolina Burgos, Federico Gago, Carmen Cuevas, Alberto Domingo, Raquel Garcı́a-Nieto, Gerónimo Fernández, Julio Alvarez-Builla, Ignacio Manzanares, Valentin Martinez
Publikováno v:
Journal of Medicinal Chemistry. 47:1136-1148
New azaquinolizinium-type cations have been obtained from isochromane. The synthesis was completed over seven steps and included as the key feature an intramolecular Westphal condensation. This first example of the intramolecular process allowed the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997c7f8fb707832dea842eea122576d7
https://doi.org/10.1021/jm0310434
https://doi.org/10.1021/jm0310434
Autor:
Ignacio Manzanares, Jesús Mendieta, Carmen Cuevas, Federico Gago, Esther Marco, Raquel Garcı́a-Nieto
Publikováno v:
Journal of Medicinal Chemistry. 45:871-880
The antitumor ecteinascidin ET743 has been shown to inhibit the transcriptional activation of a number of genes at nanomolar concentrations. Cell sensitivity to subnanomolar concentrations of the drug has also been shown to specifically depend on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ea47ab7f1ab985b77ab44b3ffef755
https://doi.org/10.1021/jm010370d
https://doi.org/10.1021/jm010370d
Publikováno v:
Journal of the American Chemical Society. 122:7172-7182
Recognition of DNA sequence information by the natural antitumor agent ecteinascidin 743 (ET743) has been proposed to operate through a direct readout mechanism involving specific hydrogen bonding interactions between the drug and the DNA minor groov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bab61faa765b3857d0621292b0fca8e3
https://doi.org/10.1021/ja000964q
https://doi.org/10.1021/ja000964q
Publikováno v:
Journal of Computer-Aided Molecular Design. 14:147-160
Molecular models of the complex between the selective COX-2 inhibitor nimesulide and the cyclooxygenase active site of human prostaglandin-endoperoxide synthase-2 have been built using a combination of homology modelling, conformational searching and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c18665659066c263627dff06cffa92b
https://doi.org/10.1023/a:1008110924479
https://doi.org/10.1023/a:1008110924479
Publikováno v:
Rheumatology. 38:14-18
The cyclooxygenase-2 (COX-2) isoenzyme is a key target for COX-2-selective non-steroidal anti-inflammatory drugs (NSAIDs). An important difference in binding of nimesulide compared with non-selective NSAIDs appears to involve the amino acid at positi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81de0679cb33010a67931986db3a2974
https://doi.org/10.1093/rheumatology/38.suppl_1.14
https://doi.org/10.1093/rheumatology/38.suppl_1.14
Publikováno v:
ChemInform. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac4898e3afa5cc06be6b9bbd8cad994d
https://doi.org/10.1002/chin.200213274
https://doi.org/10.1002/chin.200213274
Publikováno v:
Journal of Medicinal Chemistry. 43:4367-4369
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74de383a8f4f5775d845a1a381d26613
https://doi.org/10.1021/jm000322d
https://doi.org/10.1021/jm000322d
Publikováno v:
Journal of molecular biology. 328(1)
The DNA-binding domain (DBD) of the ubiquituous transcription factor Sp1 consists of three consecutive zinc fingers that recognize a number of nucleotide sequences different from, but related to and sometimes overlapping, those recognized by the stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d1de33b5b0f9d251896050783292c76
https://pubmed.ncbi.nlm.nih.gov/12683994
https://pubmed.ncbi.nlm.nih.gov/12683994
Publikováno v:
Current medicinal chemistry. Anti-cancer agents. 1(3)
Ecteinascidins are marine natural products consisting of two or three linked tetrahydroisoquinoline subunits and an active carbinolamine functional group. Their potent antiproliferative activity against a variety of tumor cells has made them attracti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2c2faee46131740664df591407a132
https://pubmed.ncbi.nlm.nih.gov/12678757
https://pubmed.ncbi.nlm.nih.gov/12678757
Autor:
Pablo Ortiz, Susana Alemany, Rosa de Gregorio, Carmen Campos, Raquel Garcı́a-Nieto, Federico Gago
Publikováno v:
e_Buah Biblioteca Digital Universidad de Alcalá
instname
instname
The ability of metamizol to inhibit cyclooxygenase-l and cyclooxygenase-2 activities has been evaluated using different cyclooxygenase sources. Metamizol inhibited purified cyclooxygenase-l and cyclooxygenase-2 with an IC50 of about 150 mu g/ml. A si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e82fe15926b3936437dbfc944da2f732
https://pubmed.ncbi.nlm.nih.gov/10493111
https://pubmed.ncbi.nlm.nih.gov/10493111