Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Raquel Gómez-Sintes"'
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-17 (2024)
Abstract Background Age-related macular degeneration (AMD) is the leading cause of blindness in elderly people in the developed world, and the number of people affected is expected to almost double by 2040. The retina presents one of the highest meta
Externí odkaz:
https://doaj.org/article/f15f134846cf48cf9a7bbee7e37d29af
Autor:
Raquel Gómez-Sintes, Beatriz Villarejo-Zori, Ana Serrano-Puebla, Lorena Esteban-Martínez, Elena Sierra-Filardi, Ignacio Ramírez-Pardo, Natalia Rodríguez-Muela, Patricia Boya
Publikováno v:
Cells, Vol 6, Iss 4, p 37 (2017)
Autophagy is a catabolic pathway that mediates the degradation and recycling of intracellular components, and is a key player in a variety of physiological processes in cells and tissues. Recent studies of autophagy in the eye suggest that this pathw
Externí odkaz:
https://doaj.org/article/9b42ac10fe0e4d7e8500eeb393415ab3
Autor:
Raquel Gómez-Sintes, José J Lucas
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70952 (2013)
Glycogen synthase kinase-3 (GSK-3) inhibitors have been postulated as useful therapeutic tools for the treatment of chronic neurodegenerative and neuropsychiatric diseases. Nevertheless the clinical use of these inhibitors has been limited by their c
Externí odkaz:
https://doaj.org/article/73a95b6204104f9e8e7b81532b05cfb5
Autor:
Jerome E. Roger, Angela Armento, Eleni Petridou, Patricia Boya, Marijana Samardzija, Raquel Gómez-Sintes, Eberhart Zrenner, Marius Ueffing, Dragana Trifunović, Christian Grimm, Wadood Haq, Andrea Corna, Mohamed Ali Jarboui, Günther Zeck, François Paquet-Durand, Pedro de la Villa
Publikováno v:
Cell Death and Differentiation
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
16 p.-7 fig.
Cone photoreceptor cell death in inherited retinal diseases, such as Retinitis Pigmentosa (RP), leads to the loss of high acuity and color vision and, ultimately to blindness. In RP, a vast number of mutations perturb the structure
Cone photoreceptor cell death in inherited retinal diseases, such as Retinitis Pigmentosa (RP), leads to the loss of high acuity and color vision and, ultimately to blindness. In RP, a vast number of mutations perturb the structure
Publikováno v:
Traffic. 19:918-931
Lysosomes are membrane-enclosed organelles that mediate the intracellular degradation of macromolecules. They play an essential role in calcium regulation and have emerged as key signaling hubs in controlling the nutrient response. Maintaining lysoso
Autor:
Mohamed Ali Jarboui, Andrea Corna, Dragana Trifunović, Christian Grimm, Wadood Haq, Eberhart Zrenner, Eleni Petridou, François Paquet-Durand, Patricia Boya, Angela Armento, Marius Ueffing, Raquel Gómez-Sintes, Marijana Samardzija, Jerome E. Roger, Günther Zeck
Cone photoreceptor cell death in inherited retinal diseases, such as Retinitis Pigmentosa (RP), leads to the loss of high acuity and color vision and ultimately to blindness. In RP, a vast number of mutations perturb the structure and function of rod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc63ee0667a54e87853b3754bf7f10f2
Autor:
Takanori Sano, José J. Lucas, Félix Hernández, Alberto Rodríguez-Matellán, Eva M. Jimenez-Mateos, Miguel Medina, Mark Dunleavy, Tobias Engel, David C. Henshall, Raquel Gómez-Sintes, Marta Fernández-Nogales, James Morgan, Mariana Alves, Jesús Avila, Amaya Sanz-Rodriguez, Edward Beamer
Publikováno v:
Cell Death and Disease, Vol 9, Iss 10, Pp 1-14 (2018)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cell Death & Disease
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cell Death & Disease
14 p.-5 fig.
Glycogen synthase kinase-3 (GSK-3) is ubiquitously expressed throughout the brain and involved in vital molecular pathways such as cell survival and synaptic reorganization and has emerged as a potential drug target for brain diseas
Glycogen synthase kinase-3 (GSK-3) is ubiquitously expressed throughout the brain and involved in vital molecular pathways such as cell survival and synaptic reorganization and has emerged as a potential drug target for brain diseas
Autor:
Elena Sierra-Filardi, Beatriz Villarejo-Zori, Ignacio Ramírez-Pardo, Lorena Esteban-Martínez, Raquel Gómez-Sintes, Natalia Rodriguez-Muela, Patricia Boya, Ana Serrano-Puebla
Publikováno v:
Cells, Vol 6, Iss 4, p 37 (2017)
Cells
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cells
Digital.CSIC. Repositorio Institucional del CSIC
instname
Autophagy is a catabolic pathway that mediates the degradation and recycling of intracellular components, and is a key player in a variety of physiological processes in cells and tissues. Recent studies of autophagy in the eye suggest that this pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb9b6b4a1e70d65a6d7ae36557a8c8a
http://hdl.handle.net/10261/156759
http://hdl.handle.net/10261/156759
Autor:
Esther García, Patricia Martín-Maestro, Jesús Avila, Raquel Gómez-Sintes, Jerónimo Jurado-Arjona, Félix Hernández, Stefano Benvegnù, Almudena Fuster-Matanzo
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cellular and Molecular Life Sciences
instname
Cellular and Molecular Life Sciences
Glycogen synthase kinase-3b (GSK-3b) is a serine-threonine kinase implicated in multiple processes and signaling pathways. Its dysregulation is associated with different pathological conditions including Alzheimer’s disease (AD). Here we demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4d75546f922fbafa8398b561bc1976
http://hdl.handle.net/10261/253863
http://hdl.handle.net/10261/253863
Autor:
Raquel Gomez-Sintes, Qisheng Xin, Juan Ignacio Jimenez-Loygorri, Mericka McCabe, Antonio Diaz, Thomas P. Garner, Xiomaris M. Cotto-Rios, Yang Wu, Shuxian Dong, Cara A. Reynolds, Bindi Patel, Pedro de la Villa, Fernando Macian, Patricia Boya, Evripidis Gavathiotis, Ana Maria Cuervo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Gomez-Sintes et al. have developed small molecules that selectively activate chaperone-mediated autophagy by stabilizing the interaction between retinoic acid receptor alpha and its co-repressor N-CoR1. They demonstrate the protective effect of boost
Externí odkaz:
https://doaj.org/article/31e22769f6804f2d8f96a489a0f64889