Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming

Autor: Javier Prieto, Marian León, Xavier Ponsoda, Ramón Sendra, Roque Bort, Raquel Ferrer-Lorente, Angel Raya, Carlos López-García, Josema Torres

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

Reprogramming of somatic cells is a stepwise process where cells must overcome several barriers before reaching the pluripotent state. Here the authors show that mitochondrial fission in response to ERK1/2 signalling is an important early step during

Externí odkaz: https://doaj.org/article/0fea78d669cb46258b35840c49ca6d36

Cationic Carbosilane Dendrimers Prevent Abnormal α-Synuclein Accumulation in Parkinson's Disease Patient-Specific Dopamine Neurons

Autor: Francisco Javier de la Mata, Raquel Ferrer-Lorente, Katarzyna Milowska, Rafael Gómez, Paula Ortega, Maria Bryszewska, Tania Lozano-Cruz, Irene Fernandez-Carasa, Angel Raya, Antonella Consiglio

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona

Accumulation of misfolded α-synuclein (α-syn) is a hallmark of Parkinson's disease (PD) thought to play important roles in the pathophysiology of the disease. Dendritic systems, able to modulate the folding of proteins, have emerged as promising ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b90900eb1878e9cad7da561c23d552
http://hdl.handle.net/2445/181542

MicroRNA alterations in iPSC-derived dopaminergic neurons from Parkinson disease patients

Autor: Raquel Ferrer-Lorente, Mario Ezquerra, María-José Martí, Manel Fernández, Teresa Botta-Orfila, Carles Calatayud, Rubén Fernández-Santiago, Xavier Morató, Antonella Consiglio, Eduard Tolosa, Angel Raya, Carles Gaig

Publikováno v: NEUROBIOLOGY OF AGING
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname

MicroRNA (miRNA) misregulation in peripheral blood has been linked to Parkinson disease (PD) but its role in the disease progression remains elusive. We performed an explorative genome-wide study of miRNA expression levels in dopaminergic neurons (DA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d927eddd065c53ea2ad02ad77df118
https://doi.org/10.1016/j.neurobiolaging.2018.05.032

Selective inhibition of sphingosine kinase-1 protects adipose tissue against LPS-induced inflammatory response in Zucker diabetic fatty rats

Autor: Mònica Tous, Lina Badimon, Raquel Ferrer-Lorente

Publikováno v: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

Obesity is associated with a state of chronic inflammation. The chemokine (C-C motif) ligand 5 (CCL5) has been proposed to modulate the inflammatory response in adipose tissue (AT). However, the mechanisms underlying CCL5 upregulation in AT remain un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cad51ad8f310739da40d700d0807191
https://doi.org/10.1152/ajpendo.00059.2014

Platelets Derived From the Bone Marrow of Diabetic Animals Show Dysregulated Endoplasmic Reticulum Stress Proteins That Contribute to Increased Thrombosis

Autor: Rodrigo Hernández Vera, Raquel Ferrer-Lorente, Esther Peña, Lina Badimon, Gemma Vilahur

Publikováno v: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

Objective— Patients with diabetes mellitus have an increased risk of suffering atherothrombotic syndromes and are prone to clustering cardiovascular risk factors. However, despite their dysregulated glucose metabolism, intensive glycemic control ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::917a774d895b563fe6052f3949ef9b31
https://doi.org/10.1161/atvbaha.112.255281