Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Raquel F. Reinoso"'
Autor:
Claudia Esposito, María Gómez, Balbino Yagüe, Sandra Yeste, Raquel F. Reinoso, Vanessa Gómez-Vallejo, Gemma Arsequell, Jordi Llop
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S400- (2023)
Externí odkaz:
https://doaj.org/article/dda1f41f60c14788bd22630631f90857
Autor:
Ariadna Fernández, Enrique Portillo-Salido, Mónica Porras, Adriana Lorente, José Miguel Vela, Carmen Almansa, Raquel Enrech, J.L. Diaz, Begoña Fernández, Albert Dordal, Sergi Rodríguez-Escrich, Raquel F. Reinoso, Mónica García
Publikováno v:
ACS Med Chem Lett
[Image: see text] The synthesis and pharmacological activities of a new series of piperazinyl quinazolin-4-(3H)-one derivatives acting toward the α2δ-1 subunit of voltage-gated calcium channels (Ca(v)α2δ-1) are reported. Different positions of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185ebf310cb9bbc8e97f822502f72c2b
https://doi.org/10.1021/acsmedchemlett.1c00416
https://doi.org/10.1021/acsmedchemlett.1c00416
Autor:
Enrique Portillo-Salido, Agustín Jiménez-Aquino, José Miguel Vela, Ana I. Oliva, Adriana Port, Gonzalo Pazos, Félix Cuevas, María Morón, Carmen Almansa, J.L. Diaz, Albert Dordal, Daniel Font, Raquel F. Reinoso, Paula Álvarez-Bercedo, M. Ángeles Sarmentero, Rosalia Pascual
Publikováno v:
Journal of Medicinal Chemistry. 64:2167-2185
The synthesis and pharmacological activity of a new series of bicyclic diazepinones with dual activity toward the α2δ-1 subunit of voltage-gated calcium channels (Cavα2δ-1) and the norepinephrine transporter (NET) are reported. Exploration of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63e44c54c3e5563d8ad6c2a2f01a1d4d
https://doi.org/10.1021/acs.jmedchem.0c01867
https://doi.org/10.1021/acs.jmedchem.0c01867
Autor:
Ariadna Balada, Maria Teresa Serafini, María José Pretel, Raquel F Reinoso, Sandra Yeste, Eva Ayet
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:68-76
EST64454 is a selective sigma-1 receptor ligand intended for orally administered pain treatment that showed a promising profile in the lead optimization process. As part of the preliminary compound profiling, the potential for future drug-drug intera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f66e63d2d83ae9a32e8758ecdca535ad
https://doi.org/10.1248/bpb.b19-00542
https://doi.org/10.1248/bpb.b19-00542
Autor:
Eva, Ayet, Sandra, Yeste, Raquel F, Reinoso, María José, Pretel, Ariadna, Balada, Maria Teresa, Serafini
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 51(5)
The potential for drug-drug interactions (DDI) of EST73502 was preliminary explored
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9bcf3759e6319587678c3147d558af38
https://pubmed.ncbi.nlm.nih.gov/33622176
https://pubmed.ncbi.nlm.nih.gov/33622176
Autor:
Maria Teresa Serafini, Eva Ayet, Sandra Yeste, Ariadna Balada, María José Pretel, Raquel F Reinoso
The potential for drug-drug interactions (DDI) of EST73502 was preliminary explored in vitro. EST73502 is a new chemical entity intended for oral pain treatment with dual sigma-1 receptor (σ1R) antagonism and μ-opioid receptor (MOR) partial agonism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7109084141fa0e931ebd5da189222f
Autor:
Eva Ayet, Sandra Yeste, María José Pretel, Maria Teresa Serafini, Raquel F Reinoso, Ariadna Balada
EST64401 and EST64514 are two selective sigma-1 receptor ligands that showed a good profile in a lead optimization process for oral pain treatment. Their potential for pharmacokinetic-based drug-drug interactions was assessed to anticipate clinical i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3101ebb9a7a96d7d7af52f0426e806f
Autor:
Raquel F, Reinoso, Sandra, Yeste, Eva, Ayet, María José, Pretel, Ariadna, Balada, Maria Teresa, Serafini
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 51(4)
EST64401 and EST64514 are two selective sigma-1 receptor ligands that showed a good profile in a lead optimization process for oral pain treatment. Their potential for pharmacokinetic-based drug-drug interactions was assessed to anticipate clinical i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::71187ac28ab7a321662d3b85a0bab0c0
https://pubmed.ncbi.nlm.nih.gov/33350877
https://pubmed.ncbi.nlm.nih.gov/33350877
Autor:
Frederik Börgel, Inés Alvarez, Elisabeth Kronenberg, Melanie Bergkemper, Raquel F. Reinoso, Constantin G. Daniliuc, Dirk Schepmann, Bernhard Wünsch, Peter Brust, Simone Thum, Francisco R. Nieto
Publikováno v:
Journal of Medicinal Chemistry 61(2018), 9666-9690
In order to detect novel σ receptor ligands, the rigit spiro [[2]benzopyran-1,1'-cyclohexan]-4'-one was connected with amino moieties derived from σ2 receptor preferring lead compounds resulting in mixtures of trans- and cis-configured amines 6, 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35cf0bd4445bc74d19af06e95ef3ec41
https://doi.org/10.1021/acs.jmedchem.8b01183
https://doi.org/10.1021/acs.jmedchem.8b01183
Autor:
Raquel F. Reinoso, Simon M. Ametamey, Inés Alvarez, Bernhard Wünsch, Dirk Schepmann, Simone Thum
Publikováno v:
Journal of labelled compoundsradiopharmaceuticals. 62(8)
Because of their neuroprotective potential, GluN2B-selective ligands are of great interest for the treatment of various neurological and neurodegenerative disorders. Fluorinated benzo[7]annulen-7-amines, capable for PET, were synthesized by combining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7aa8c83f2a16eae6c771c9fd8acad4
https://pubmed.ncbi.nlm.nih.gov/30850991
https://pubmed.ncbi.nlm.nih.gov/30850991