Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Raquel E. Rodríguez"'
Publikováno v:
Molecular Medicine, Vol 19, Iss 1, Pp 7-17 (2013)
Abstract It is well known that genotypic differences can account for the subject-specific responses to opiate administration. In this regard, the basal activity of the endogenous system (either at the receptor or ligand level) can modulate the effect
Externí odkaz:
https://doaj.org/article/d20d187835f14296b3d8e2fda77415e0
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0157806 (2016)
Since their discovery, miRNAs have emerged as a promising therapeutical approach in the treatment of several diseases, as demonstrated by miR-212 and its relation to addiction. Here we prove that the miR-212/132 cluster can be regulated by morphine,
Externí odkaz:
https://doaj.org/article/1f64343f43b14c06bef4c51e96d556b1
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1862:2605-2612
Background The abuse of opioids, such as morphine and phentanyl or other drugs as heroin is a social and health problem that affects an increasing number of people each year. The activation of the mu opioid receptor triggers several molecular changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d9a4707827bf3e9411642a8f07eb93
https://doi.org/10.1016/j.bbagen.2018.07.001
https://doi.org/10.1016/j.bbagen.2018.07.001
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50885 (2012)
Prenatal exposure to cocaine, in mammals, has been shown to interfere with the expression of opioid receptors, which can have repercussions in its activity. Likewise, microRNAs, such as let-7, have been shown to regulate the expression of opioid rece
Externí odkaz:
https://doaj.org/article/d9cbd49b54be425ba980f5337b6d16ef
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52701 (2012)
The use of cocaine during pregnancy can affect the mother and indirectly might alter the development of the embryo/foetus. Accordingly, in the present work our aim was to study in vivo (in zebrafish embryos) the effects of cocaine on the expression o
Externí odkaz:
https://doaj.org/article/27faa79ca0ab4cbb9b89acc155f6d5b4
Autor:
Ada Jimenez-Gonzalez, Raquel E. Rodríguez, Juan Carlos Arévalo, Veronica Gonzalez-Nunez, Adrián García-Concejo, Saray López-Benito
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1860:1308-1316
Background Morphine is one of the first-line therapies for the treatment of pain despite its secondary effects. It modifies the expression of epigenetic factors like miRNAs. In the present study, we analyzed miR-212 and miR-132 and their implication
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e3093389b0b2d8bb9bf02fc4a57b93
https://doi.org/10.1016/j.bbagen.2016.03.001
https://doi.org/10.1016/j.bbagen.2016.03.001
Autor:
María Torres-Valle, Raquel E. Rodríguez, Cristina Vicente-García, Juan Carlos Arévalo, Roman S. Iwasaki, Roger López-Bellido, Enrique Hernández-Jiménez, Ada Jimenez-Gonzalez
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 19; Issue 1; Pages: 14
GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname
International Journal of Molecular Sciences; Volume 19; Issue 1; Pages: 14
GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname
[EN] The opioid system is well conserved among species and plays a critical role in pain and addiction systems. The use of zebrafish as an experimental model to study development and genetics is extraordinary and has been proven to be relevant for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd6f4c61ae3a72e381aa8ef87664743
https://hdl.handle.net/10366/140748
https://hdl.handle.net/10366/140748
Autor:
Katy Barreto-Valer, Leonardo Pardo, Jesús Jiménez-Barbero, Gianluigi Caltabiano, Ana Ardá, Gregorio Valencia, Veronica Gonzalez-Nunez, Mònica Rosa, Gemma Arsequell, Raquel E. Rodríguez, José Carlos Gómez-Tamayo
Publikováno v:
ACS Medicinal Chemistry Letters. 6:872-876
Systematic halogenation of two native opioid peptides has shown that halogen atoms can modulate peptide-receptor interactions in different manners. First, halogens may produce a steric hindrance that reduces the binding of the peptide to the receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad7d68537b8a33f0e0597f729201706d
https://doi.org/10.1021/acsmedchemlett.5b00126
https://doi.org/10.1021/acsmedchemlett.5b00126
Publikováno v:
Biochimica et biophysica acta. General subjects. 1862(3)
Background Morphine is used as an analgesic although it causes important secondary effects. These effects are triggered by several mechanisms leading to the dysregulation of gene expression. Here we aimed to study these alterations on neural stem cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac55368053f2fc41d367b683731d071
https://pubmed.ncbi.nlm.nih.gov/29111275
https://pubmed.ncbi.nlm.nih.gov/29111275
Publikováno v:
Neuroscience. 231:258-271
Nodal-related protein, Ndr2, and transcription factors such as Lmx1b, Otp, Nurr1 and Pitx3 are very important in the differentiation, function and maintenance of mesodiencephalic dopaminergic neurons, and are necessary for the activation of tyrosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407196b1667e8d60ab77c7127df12cf7
https://doi.org/10.1016/j.neuroscience.2012.11.052
https://doi.org/10.1016/j.neuroscience.2012.11.052