Flower lose, a cell fitness marker, predicts COVID‐19 prognosis

Autor: Michail Yekelchyk, Esha Madan, Jochen Wilhelm, Kirsty R Short, António M Palma, Linbu Liao, Denise Camacho, Everlyne Nkadori, Michael T Winters, Emily S Rice, Inês Rolim, Raquel Cruz‐Duarte, Christopher J Pelham, Masaki Nagane, Kartik Gupta, Sahil Chaudhary, Thomas Braun, Raghavendra Pillappa, Mark S Parker, Thomas Menter, Matthias Matter, Jasmin Dionne Haslbauer, Markus Tolnay, Kornelia D Galior, Kristina A Matkwoskyj, Stephanie M McGregor, Laura K Muller, Emad A Rakha, Antonio Lopez‐Beltran, Ronny Drapkin, Maximilian Ackermann, Paul B Fisher, Steven R Grossman, Andrew K Godwin, Arutha Kulasinghe, Ivan Martinez, Clay B Marsh, Benjamin Tang, Max S Wicha, Kyoung Jae Won, Alexandar Tzankov, Eduardo Moreno, Rajan Gogna

Publikováno v: EMBO Molecular Medicine, Vol 13, Iss 11, Pp 1-17 (2021)

Abstract Risk stratification of COVID‐19 patients is essential for pandemic management. Changes in the cell fitness marker, hFwe‐Lose, can precede the host immune response to infection, potentially making such a biomarker an earlier triage tool.

Externí odkaz: https://doaj.org/article/f8eb078fb27a469bb4350f69d131fd6a

Supplementary Figure from Predictive and Therapeutic Implications of a Novel PLCγ1/SHP2-Driven Mechanism of Cetuximab Resistance in Metastatic Colorectal Cancer

Autor: Marta Martins, Luís Costa, Rita Fior, André Mansinho, Ana Lucia-Costa, Catarina Abreu, Teresa R. Pacheco, Maria J. Brito, Helder Mansinho, Ana R. Miranda, Miguel Godinho Ferreira, Ana T. Xavier, José Vílchez, João Gramaça, Daniel Machado, Lina M. Gallego-Paez, Daniel Sobral, Paula Borralho, Afonso Fernandes, Magda Negrão, Cátia Rebelo de Almeida, Raquel Cruz-Duarte

Supplementary Figure from Predictive and Therapeutic Implications of a Novel PLCγ1/SHP2-Driven Mechanism of Cetuximab Resistance in Metastatic Colorectal Cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::083ae1169e4cc776a94303306d7877c5
https://doi.org/10.1158/1078-0432.22484019

Predictive and Therapeutic Implications of a Novel PLCγ1/SHP2-Driven Mechanism of Cetuximab Resistance in Metastatic Colorectal Cancer

Autor: Raquel Cruz-Duarte, Cátia Rebelo de Almeida, Magda Negrão, Afonso Fernandes, Paula Borralho, Daniel Sobral, Lina M. Gallego-Paez, Daniel Machado, João Gramaça, José Vílchez, Ana T. Xavier, Miguel Godinho Ferreira, Ana R. Miranda, Helder Mansinho, Maria J. Brito, Teresa R. Pacheco, Catarina Abreu, Ana Lucia-Costa, André Mansinho, Rita Fior, Luís Costa, Marta Martins

Publikováno v: Clinical Cancer Research
Clinical Cancer Research, American Association for Cancer Research, 2022, pp.clincanres.1992.2021. ⟨10.1158/1078-0432.CCR-21-1992⟩

© 2022 The Authors; Published by the American Association for Cancer Research. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 International (CC BY-NC-ND)
Purpose: Cetuximab is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a8c83eb18a02ddfbb46b4b0884da178
https://doi.org/10.1158/1078-0432.ccr-21-1992

Flower lose, a cell fitness marker, predicts COVID‐19 prognosis

Autor: Christopher J Pelham, Esha Madan, Markus Tolnay, António M Palma, Emad A. Rakha, Stephanie M. McGregor, Maximilian Ackermann, Everlyne Nkadori, Alexandar Tzankov, Laura K. Muller, Linbu Liao, Mark S. Parker, Emily S Rice, Jasmin D. Haslbauer, Thomas Braun, Raquel Cruz-Duarte, Andrew K. Godwin, Max S. Wicha, Thomas Menter, Matthias S. Matter, Denise Camacho, Benjamin Tang, Kirsty R. Short, Kyoung-Jae Won, Paul B. Fisher, Michail Yekelchyk, Kristina A Matkwoskyj, Eduardo Moreno, Sahil Chaudhary, Rajan Gogna, Kornelia Galior, Inês Rolim, Masaki Nagane, Ronny Drapkin, Michael T. Winters, Kartik Gupta, Antonio Lopez-Beltran, Ivan Martinez, Arutha Kulasinghe, Clay B. Marsh, Jochen Wilhelm, Steven R Grossman, Raghavendra Pillappa

Publikováno v: EMBO Molecular Medicine
Yekelchyk, M, Madan, E, Wilhelm, J, Short, K R, Palma, A M, Liao, L, Camacho, D, Nkadori, E, Winters, M T, Rice, E S, Rolim, I, Cruz-Duarte, R, Pelham, C J, Nagane, M, Gupta, K, Chaudhary, S, Braun, T, Pillappa, R, Parker, M S, Menter, T, Matter, M, Haslbauer, J D, Tolnay, M, Galior, K D, Matkwoskyj, K A, McGregor, S M, Muller, L K, Rakha, E A, Lopez-Beltran, A, Drapkin, R, Ackermann, M, Fisher, P B, Grossman, S R, Godwin, A K, Kulasinghe, A, Martinez, I, Marsh, C B, Tang, B, Wicha, M S, Won, K J, Tzankov, A, Moreno, E & Gogna, R 2021, ' Flower lose, a cell fitness marker, predicts COVID-19 prognosis ', EMBO Molecular Medicine, vol. 13, no. 11, e13714 . https://doi.org/10.15252/emmm.202013714
EMBO Molecular Medicine, Vol 13, Iss 11, Pp n/a-n/a (2021)

Risk stratification of COVID‐19 patients is essential for pandemic management. Changes in the cell fitness marker, hFwe‐Lose, can precede the host immune response to infection, potentially making such a biomarker an earlier triage tool. Here, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::045218b1b4e74ca44637e231ad591f82
https://doi.org/10.15252/emmm.202013714

Anti-EGFR Therapy to Treat Metastatic Colorectal Cancer: Not for All

Autor: André Mansinho, Raquel Cruz-Duarte, Soraia Lobo Martins, Marta Martins, Luis Costa

Publikováno v: Targeted Therapy of Colorectal Cancer Subtypes ISBN: 9783030027704

The development of monoclonal antibodies (mAbs) cetuximab and panitumumab, which target the transmembrane protein epidermal growth factor receptor (EGFR), mark a major step forward in the treatment of metastatic colorectal cancer (mCRC). However, thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d497c4a12fd76f2f1ca6f97eee3c7517
https://doi.org/10.1007/978-3-030-02771-1_8