Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Raquel Carvalho-Gontijo"'
Autor:
Hyun Young Kim, Wonseok Lee, Xiao Liu, Haeum Jang, Sadatsugu Sakane, Raquel Carvalho-Gontijo Weber, Karin Diggle, Samuel A. Kerk, Christian M. Metallo, Tatiana Kisseleva, David A. Brenner
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 103111- (2024)
Summary: Currently, there is no effective treatment for obesity and alcohol-associated liver diseases, partially due to the lack of translational human models. Here, we present a protocol to generate 3D human liver spheroids that contain all the live
Externí odkaz:
https://doaj.org/article/4d3e50db289e472d86f78e55cfae2e45
Autor:
Ariane Barros Diniz, Maísa Mota Antunes, Viviane Aparecida de Souza Lacerda, Brenda Naemi Nakagaki, Maria Alice Freitas Lopes, Hortência Maciel de Castro-Oliveira, Matheus Silvério Mattos, Kassiana Mafra, Camila Dutra Moreira de Miranda, Karen Marques de Oliveira Costa, Mateus Eustáquio Lopes, Débora Moreira Alvarenga, Raquel Carvalho-Gontijo, Sarah Cozzer Marchesi, Debora Romualdo Lacerda, Alan Moreira de Araújo, Érika de Carvalho, Bruna Araújo David, Mônica Morais Santos, Cristiano Xavier Lima, Juliana Assis Silva Gomes, Tereza Cristina Minto Fontes Cal, Bruna Roque de Souza, Cláudia Alves Couto, Luciana Costa Faria, Paula Vieira Teixeira Vidigal, Adaliene Versiane Matos Ferreira, Sridhar Radhakrishnnan, Matthew Ricci, André Gustavo Oliveira, Rafael Machado Rezende, Gustavo Batista Menezes
Publikováno v:
JHEP Reports, Vol 2, Iss 4, Pp 100117- (2020)
Background & Aims: The precise determination of non-alcoholic fatty liver disease (NAFLD) onset is challenging. Thus, the initial hepatic responses to fat accumulation, which may be fundamental to our understanding of NAFLD evolution and clinical out
Externí odkaz:
https://doaj.org/article/7d7eb353ab4a40bd87cfa66e7e4af738
Autor:
BRENDA N. NAKAGAKI, MARIA A. FREITAS-LOPES, ÉRIKA CARVALHO, RAQUEL CARVALHO-GONTIJO, HORTÊNCIA M. CASTRO-OLIVEIRA, RAFAEL M. REZENDE, DENISE C. CARA, MÔNICA M. SANTOS, RODRIGO PESTANA LOPES, BRUNA A. DAVID, GUSTAVO B. MENEZES
Publikováno v:
Anais da Academia Brasileira de Ciências, Iss 0 (2017)
ABSTRACT Resident and circulating immune cells have been extensively studied due to their almost ubiquitous role in cell biology. Despite their classification under the “immune cell department”, it is becoming increasingly clear that these cells
Externí odkaz:
https://doaj.org/article/72399394402d4373ae12a21f05a38e5e
Autor:
Alan Moreira de Araujo, Maísa Mota Antunes, Matheus Silvério Mattos, Ariane Barros Diniz, Débora Moreira Alvarenga, Brenda Naemi Nakagaki, Érika de Carvalho, Viviane Aparecida Souza Lacerda, Raquel Carvalho-Gontijo, Jorge Goulart, Kassiana Mafra, Maria Alice Freitas-Lopes, Hortência Maciel de Castro Oliveira, Camila Miranda Dutra, Bruna Araújo David, Aristóbolo Mendes Silva, Valerie Quesniaux, Bernhard Ryffel, Sergio Costa Oliveira, Glen N. Barber, Daniel Santos Mansur, Thiago Mattar Cunha, Rafael Machado Rezende, André Gustavo Oliveira, Gustavo Batista Menezes
Publikováno v:
Cells, Vol 7, Iss 8, p 88 (2018)
Hepatocytes may rupture after a drug overdose, and their intracellular contents act as damage-associated molecular patterns (DAMPs) that lead to additional leukocyte infiltration, amplifying the original injury. Necrosis-derived DNA can be recognized
Externí odkaz:
https://doaj.org/article/d9d470a10b70477fb0716d37720427e5
Autor:
Maria Alice Freitas-Lopes, Kassiana Mafra, Bruna A. David, Raquel Carvalho-Gontijo, Gustavo B. Menezes
Publikováno v:
Cells, Vol 6, Iss 4, p 48 (2017)
The liver is one of the main organs in the body, performing several metabolic and immunological functions that are indispensable to the organism. The liver is strategically positioned in the abdominal cavity between the intestine and the systemic cir
Externí odkaz:
https://doaj.org/article/47573459dcb4437f9bd27de400315aba
Akademický článek
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Akademický článek
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Autor:
Cuijuan Han, Raquel Carvalho-Gontijo, Lei Zhang, Vivian Zhang, Mojgan Hosseini, Kristin Mekeel, Bernd Schnabl, Rohit Loomba, Michael Karin, David A. Brenner, Tatiana Kisseleva
Publikováno v:
Semin Liver Dis
Seminars in liver disease, vol 42, iss 3
Seminars in liver disease, vol 42, iss 3
Nonalcoholic liver disease is a component of metabolic syndrome associated with obesity, insulin resistance, and hyperlipidemia. Excessive alcohol consumption may accelerate the progression of steatosis, steatohepatitis, and fibrosis. While simple st
Autor:
Jennifer L. Johnson, Elsa Meneses-Salas, Mahalakshmi Ramadass, Jlenia Monfregola, Farhana Rahman, Raquel Carvalho Gontijo, William B. Kiosses, Kersi Pestonjamasp, Dale Allen, Jinzhong Zhang, Douglas G. Osborne, Yanfang Peipei Zhu, Nathan Wineinger, Kasra Askari, Danni Chen, Juan Yu, Scott C. Henderson, Catherine C. Hedrick, Matilde Valeria Ursini, Sergio Grinstein, Daniel D. Billadeau, Sergio D. Catz
Publikováno v:
Nature Communications. 13
Dysregulated secretion in neutrophil leukocytes associates with human inflammatory disease. The exocytosis response to triggering stimuli is sequential; gelatinase granules modulate the initiation of the innate immune response, followed by the releas
Autor:
Sergio D. Catz, Kersi Pestonjamasp, Elsa Meneses-Salas, Catherine C. Hedrick, Raquel Carvalho Gontijo, Jenny E. Gunton, Mahalakshmi Ramadass, Gennaro Napolitano, Nadia R Zgajnar, Jennifer L. Johnson, William B. Kiosses, Yanfang Peipei Zhu, Farhana Rahman, Jinzhong Zhang, Marta Perego
Publikováno v:
Journal of Leukocyte Biology. 110:629-649
Despite the important function of neutrophils in the eradication of infections and induction of inflammation, the molecular mechanisms regulating the activation and termination of the neutrophil immune response is not well understood. Here, the funct