Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Raquel Álvarez-Velilla"'
Autor:
Camino Gutiérrez-Corbo, Raquel Álvarez-Velilla, Rosa M. Reguera, Carlos García-Estrada, Mark Cushman, Rafael Balaña-Fouce, Yolanda Pérez-Pertejo
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 11, Iss , Pp 39-48 (2019)
DNA topoisomerases are considered consolidated druggable targets against diseases produced by trypanosomatids. Several reports indicated that indenoisoquinolines, a family of non-camptothecinic based topoisomerase poisons, have a strong leishmanicida
Externí odkaz:
https://doaj.org/article/21ddd2f2027d4c5f8e89bf2d40fc1b9c
Autor:
Rosa M. Reguera, Raquel Álvarez-Velilla, Bárbara Domínguez-Asenjo, Camino Gutiérrez-Corbo, Rafael Balaña-Fouce, Mark Cushman, Yolanda Pérez-Pertejo
Publikováno v:
BMC Veterinary Research, Vol 15, Iss 1, Pp 1-8 (2019)
Abstract Background Canine leishmaniasis is a zoonotic disease caused by Leishmania infantum, being the dogs one of the major reservoirs of human visceral leishmaniasis. DNA topology is a consolidated target for drug discovery. In this regard, topois
Externí odkaz:
https://doaj.org/article/5da0e8c1c7e443c98fbb04c8d4302acc
Autor:
Raquel Álvarez-Velilla, Maria Del Camino Gutiérrez-Corbo, Carmen Punzón, Maria Yolanda Pérez-Pertejo, Rafael Balaña-Fouce, Manuel Fresno, Rosa María Reguera
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 2, p e0007133 (2019)
BACKGROUND:Visceral leishmaniasis is a neglected parasitic disease with no vaccine available and its pharmacological treatment is reduced to a limited number of unsafe drugs. The scarce readiness of new antileishmanial drugs is even more alarming whe
Externí odkaz:
https://doaj.org/article/9b22059eb700424ea46e4480c3bcf387
Autor:
Rafael Balaña-Fouce, Raquel Álvarez-Velilla, Christopher Fernández-Prada, Carlos García-Estrada, Rosa M. Reguera
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 4, Iss 3, Pp 326-337 (2014)
The Trypanosomatidae family, composed of unicellular parasites, causes severe vector-borne diseases that afflict human populations worldwide. Chagas disease, sleeping sickness, as well as different sorts of leishmaniases are amongst the most importan
Externí odkaz:
https://doaj.org/article/86224491a0944dbd9896230e8269e1a9
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 4, Iss 3, Pp 355-357 (2014)
Drug discovery programs sponsored by public or private initiatives pursue the same ambitious goal: a crushing defeat of major Neglected Tropical Diseases (NTDs) during this decade. Both target-based and target-free screenings have pros and cons when
Externí odkaz:
https://doaj.org/article/c5e59c14f2ba4dca8a55997e99eeae3c
Autor:
Estefanía Calvo-Álvarez, Raquel Álvarez-Velilla, Maribel Jiménez, Ricardo Molina, Yolanda Pérez-Pertejo, Rafael Balaña-Fouce, Rosa M Reguera
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 5, p e0004741 (2016)
[This corrects the article DOI: 10.1371/journal.pntd.0003075.].
Externí odkaz:
https://doaj.org/article/22dfcd4ac7aa4751941b645e78a4c402
Autor:
Estefanía Calvo-Álvarez, Kostantinos Stamatakis, Carmen Punzón, Raquel Álvarez-Velilla, Ana Tejería, José Miguel Escudero-Martínez, Yolanda Pérez-Pertejo, Manuel Fresno, Rafael Balaña-Fouce, Rosa M Reguera
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 3, p e0003666 (2015)
BACKGROUND:Visceral leishmaniasis (VL) is hypoendemic in the Mediterranean region, where it is caused by the protozoan Leishmania infantum. An effective vaccine for humans is not yet available and the severe side-effects of the drugs in clinical use,
Externí odkaz:
https://doaj.org/article/2d5d420e6cb7481b8cae71aaac0a7e0c
Autor:
Estefanía Calvo-Álvarez, Raquel Álvarez-Velilla, Maribel Jiménez, Ricardo Molina, Yolanda Pérez-Pertejo, Rafael Balaña-Fouce, Rosa M Reguera
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 9, p e3075 (2014)
The mode of reproduction in Leishmania spp has been argued to be essentially clonal. However, recent data (genetic analysis of populations and co-infections in sand flies) have proposed the existence of a non-obligate sexual cycle in the extracellula
Externí odkaz:
https://doaj.org/article/05480366a48741c68ef4518f30d3cbc4
Autor:
Christopher F Prada, Raquel Álvarez-Velilla, Rosario Díaz-Gozález, Yolanda Pérez-Pertejo, Rafael Balaña-Fouce, Rosa M Reguera
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73565 (2013)
Leishmania donovani, the causative organism for visceral leishmaniasis, contains a unique heterodimeric DNA-topoisomerase IB (LdTopIB). LdTopIB is a heterodimer made up of a large subunit and a small subunit that must interact with each other to buil
Externí odkaz:
https://doaj.org/article/0c48e5c70ca94fcf80063250bb4dc979
Autor:
Raquel Álvarez-Velilla, Mark Cushman, Rosa M. Reguera, Rafael Balaña-Fouce, Yolanda Pérez-Pertejo, Camino Gutiérrez-Corbo, Carlos García-Estrada
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 11, Iss, Pp 39-48 (2019)
International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance
DNA topoisomerases are considered consolidated druggable targets against diseases produced by trypanosomatids. Several reports indicated that indenoisoquinolines, a family of non-camptothecinic based topoisomerase poisons, have a strong leishmanicida