Zobrazeno 1 - 10
of 230
pro vyhledávání: '"Raquel, Hontecillas"'
Autor:
Nuria Tubau-Juni, Josep Bassaganya-Riera, Andrew J. Leber, Sameeksha S. Alva, Ryan Baker, Raquel Hontecillas
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Clostridioides difficile infection (CDI) is the leading cause of antibiotic-associated diarrhea, and its clinical symptoms can span from asymptomatic colonization to pseudomembranous colitis and even death. The current standard of care for C
Externí odkaz:
https://doaj.org/article/c6144bacee3149aaa47fc7de462e72ae
Autor:
Ryan Baker, Raquel Hontecillas, Nuria Tubau-Juni, Andrew J. Leber, Shiv Kale, Josep Bassaganya-Riera
Publikováno v:
npj Systems Biology and Applications, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract We built a computational model of complex mechanisms at the intersection of immunity and metabolism that regulate CD4+ T cell effector and regulatory functions by using coupled ordinary differential equations. The model provides an improved
Externí odkaz:
https://doaj.org/article/9754d031717c4f2591084d2eeacaf939
Autor:
Nuria Tubau-Juni, Raquel Hontecillas, Andrew Leber, Panita Maturavongsadit, Jyoti Chauhan, Josep Bassaganya-Riera
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Psoriasis (PsO) is a complex immune-mediated disease that afflicts 100 million people. Omilancor is a locally-acting, small molecule that selectively activates the Lanthionine Synthetase C-like 2 (LANCL2) pathway, resulting in immunoregulato
Externí odkaz:
https://doaj.org/article/c1c4b1022cbb4c39b88270c685e5b4e6
Autor:
Bridget Kastelberg, Tariq Ayubi, Nuria Tubau-Juni, Andrew Leber, Raquel Hontecillas, Josep Bassaganya-Riera, Shiv D. Kale
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The Nlr family member X1 (Nlrx1) is an immuno-metabolic hub involved in mediating effective responses to virus, bacteria, fungi, cancer, and auto-immune diseases. We have previously shown that Nlrx1 is a critical regulator of immune signaling and mor
Externí odkaz:
https://doaj.org/article/e39ee8d27ab84fe38efeac95a51892aa
Autor:
Jiang Li, Yanfei Zhang, Alexandria L. Jilg, Donna M. Wolk, Harshit S. Khara, Amy Kolinovsky, David D. K. Rolston, Raquel Hontecillas, Josep Bassaganya-Riera, Marc S. Williams, Vida Abedi, Ming Ta Michael Lee
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundClostridioides difficile is a major cause of healthcare-associated and community-acquired diarrhea. Host genetic susceptibility to Clostridioides difficile infection has not been studied on a large-scale.MethodsA total of 1,160 Clostridioid
Externí odkaz:
https://doaj.org/article/7759557e633a45d4a3858d28110d609c
Autor:
Bridget Kastelberg, Nuria Tubau-Juni, Tariq Ayubi, Austin Leung, Andrew Leber, Raquel Hontecillas, Josep Bassaganya-Riera, Shiv D Kale
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008854 (2020)
Aspergillus fumigatus is an opportunistic fungal pathogen of immunocompromised patient populations. Mortality is thought to be context-specific and occurs via both enhanced fungal growth and immunopathogenesis. NLRX1 is a negative regulator of immune
Externí odkaz:
https://doaj.org/article/77f386d51f08479989c5680a9aa91e55
Autor:
Vaibhav Sharma, Vishakha Sharma, Ayesha Khan, David J. Wassmer, Matthew D. Schoenholtz, Raquel Hontecillas, Josep Bassaganya-Riera, Ramin Zand, Vida Abedi
Publikováno v:
Frontiers in Nutrition, Vol 7 (2020)
Nutrition plays a vital role in health and the recovery process. Deficiencies in macronutrients and micronutrients can impact the development and progression of various disorders. However, malnutrition screening tools and their utility in the clinica
Externí odkaz:
https://doaj.org/article/0993c01996234bc6a63282faa308bbe2
Autor:
Danielle L. Porier, Sarah N. Wilson, Dawn I. Auguste, Andrew Leber, Sheryl Coutermarsh-Ott, Irving C. Allen, Clayton C. Caswell, James A. Budnick, Josep Bassaganya-Riera, Raquel Hontecillas, James Weger-Lucarelli, Scott C. Weaver, Albert J. Auguste
Publikováno v:
Vaccines, Vol 9, Iss 10, p 1142 (2021)
Vaccination remains critical for viral disease outbreak prevention and control, but conventional vaccine development typically involves trade-offs between safety and immunogenicity. We used a recently discovered insect-specific flavivirus as a vector
Externí odkaz:
https://doaj.org/article/38a97a5ba5ee4c09ac815d6d7477d27c
Autor:
Shiv D. Kale, Tariq Ayubi, Dawoon Chung, Nuria Tubau-Juni, Andrew Leber, Ha X. Dang, Saikumar Karyala, Raquel Hontecillas, Christopher B. Lawrence, Robert A. Cramer, Josep Bassaganya-Riera
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-25 (2017)
Abstract Incidences of invasive pulmonary aspergillosis, an infection caused predominantly by Aspergillus fumigatus, have increased due to the growing number of immunocompromised individuals. While A. fumigatus is reliant upon deficiencies in the hos
Externí odkaz:
https://doaj.org/article/3e1eb754a5404bed9918e73fc0cf64c9
Autor:
Xi Chen, Wenjing Wang, Guangrui Xie, Raquel Hontecillas, Meghna Verma, Andrew Leber, Josep Bassaganya-Riera, Vida Abedi
Publikováno v:
Frontiers in Applied Mathematics and Statistics, Vol 5 (2019)
Computational immunology studies the interactions between the components of the immune system that includes the interplay between regulatory and inflammatory elements. It provides a solid framework that aids the conversion of pre-clinical and clinica
Externí odkaz:
https://doaj.org/article/2caa908006f44a9f9ff14b5d700fd608