Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Raquel, Centeio"'
Autor:
Jiraporn Ousingsawat, Raquel Centeio, Nicole Reyne, Alexandra McCarron, Patricia Cmielewski, Rainer Schreiber, Gabriella diStefano, Dorothee Römermann, Ursula Seidler, Martin Donnelley, Karl Kunzelmann
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The Ca2+ activated Cl− channel TMEM16A (anoctamin 1; ANO1) is expressed in secretory epithelial cells of airways and intestine. Previous studies provided evidence for a role of ANO1 in mucus secretion. In the present study we investigated
Externí odkaz:
https://doaj.org/article/06c1135f56334127a708313a72426579
Autor:
Karl Kunzelmann, Raquel Centeio, Jiraporn Ousingsawat, Khaoula Talbi, Ursula Seidler, Rainer Schreiber
Publikováno v:
Channels, Vol 17, Iss 1 (2023)
ABSTRACTSLC26A9 is one out of 11 proteins that belong to the SLC26A family of anion transporters. Apart from expression in the gastrointestinal tract, SLC26A9 is also found in the respiratory system, in male tissues and in the skin. SLC26A9 has gaine
Externí odkaz:
https://doaj.org/article/4fe0fe1fe0f14cb381bb1534fce08f9c
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Cl− channels such as the Ca2+ activated Cl− channel TMEM16A and the Cl− permeable phospholipid scramblase TMEM16F may affect the intracellular Cl− concentration ([Cl−]i), which could act as an intracellular signal. Loss of airway expression
Externí odkaz:
https://doaj.org/article/0e802036df2e47f9be703b08629185d7
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
All vertebrate cells activate Cl– currents (ICl,swell) when swollen by hypotonic bath solution. The volume-regulated anion channel VRAC has now been identified as LRRC8/SWELL1. However, apart from VRAC, the Ca2+-activated Cl– channel (CaCC) TMEM1
Externí odkaz:
https://doaj.org/article/cdbe9840da60450498b4ebddf3a7f66a
Autor:
Iris A. L. Silva, Aires Duarte, Fernando A. L. Marson, Raquel Centeio, Tereza Doušová, Karl Kunzelmann, Margarida D. Amaral
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Most cases of Cystic Fibrosis (CF) are diagnosed early in life. However, people with atypical CF forms pose diagnosis dilemmas, requiring laboratory support for diagnosis confirmation/exclusion. Ex vivo analysis of fresh rectal biopsies by Ussing cha
Externí odkaz:
https://doaj.org/article/815f2523473f48c48693bc41f9c09bba
Publikováno v:
Membranes, Vol 11, Iss 9, p 723 (2021)
Regulation of the Ca2+-activated Cl− channel TMEM16A by Ca2+/calmodulin (CAM) is discussed controversially. In the present study, we compared regulation of TMEM16A by Ca2+/calmodulin (holo-CAM), CAM-dependent kinase (CAMKII), and CAM-dependent phos
Externí odkaz:
https://doaj.org/article/5e0882f327974cd7ae8d780429728ead
Autor:
Karl Kunzelmann, Raquel Centeio, Podchanart Wanitchakool, Inês Cabrita, Roberta Benedetto, Tultul Saha, Kazi Mirajul Hoque, Rainer Schreiber
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Cl– secretion by the human and murine intestinal epithelium occurs through the cystic fibrosis transmembrane conductance regulator (cftr). However, the Ca2+ activated Cl– channel Tmem16a was shown to contribute to Cl– secretion, mainly, but not
Externí odkaz:
https://doaj.org/article/53df0f54cae54fc9ba59bfeea3e28ec3
Autor:
Sungwoo Jo, Raquel Centeio, Jinhong Park, Jiraporn Ousingsawat, Dong‐kyu Jeon, Khaoula Talbi, Rainer Schreiber, Kunhi Ryu, Kristin Kahlenberg, Veronika Somoza, Livia Delpiano, Michael A. Gray, Margarida D. Amaral, Violeta Railean, Jeffrey M. Beekman, Lisa W. Rodenburg, Wan Namkung, Karl Kunzelmann
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84df78702cc97c0ab313559f457294ee
https://doi.org/10.1096/fj.202200313rr
https://doi.org/10.1096/fj.202200313rr
Autor:
Lisa W. Rodenburg, Livia Delpiano, Violeta Railean, Raquel Centeio, Madalena C. Pinto, Shannon M. A. Smits, Isabelle S. van der Windt, Casper F. J. van Hugten, Sam F. B. van Beuningen, Remco N. P. Rodenburg, Cornelis K. van der Ent, Margarida D. Amaral, Karl Kunzelmann, Michael A. Gray, Jeffrey M. Beekman, Gimano D. Amatngalim
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 20; Pages: 12657
Individuals with Cystic Fibrosis (CF) suffer from severe respiratory disease due to a genetic defect in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene, which impairs airway epithelial ion and fluid secretion. New CFTR modulators
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77607e7be56cda9c2ffed67cfddca9fb
https://doi.org/10.1101/2022.09.23.509034
https://doi.org/10.1101/2022.09.23.509034
Autor:
Sungwoo, Jo, Raquel, Centeio, Jinhong, Park, Jiraporn, Ousingsawat, Dong-Kyu, Jeon, Khaoula, Talbi, Rainer, Schreiber, Kunhi, Ryu, Kristin, Kahlenberg, Veronika, Somoza, Livia, Delpiano, Michael A, Gray, Margarida D, Amaral, Violeta, Railean, Jeffrey M, Beekman, Lisa W, Rodenburg, Wan, Namkung, Karl, Kunzelmann
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 36(11)
The solute carrier 26 family member A9 (SLC26A9) is an epithelial anion transporter that is assumed to contribute to airway chloride secretion and surface hydration. Whether SLC26A9 or CFTR is responsible for airway Cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c3cea7d2fcdf1a23111e7c3069f6e1a5
https://pubmed.ncbi.nlm.nih.gov/36183361
https://pubmed.ncbi.nlm.nih.gov/36183361