Výsledky vyhledávání - "Raqeeb G. Jamil"

Expression of the Anthracycline-Metabolizing Enzyme Carbonyl Reductase 1 in Hearts from Donors with Down Syndrome

Autor: James L. Kalabus, Carrie C. Sanborn, Javier G. Blanco, Qiuying Cheng, Raqeeb G. Jamil

Publikováno v: Drug Metabolism and Disposition. 38:2096-2099

Cancer patients with Down syndrome (DS) are susceptible to developing anthracycline-related cardiotoxicity. The pathogenesis of anthracycline-related cardiotoxicity has been linked to the intracardiac synthesis of alcohol metabolites by carbonyl redu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b92a73985d6dc00b1d215b52af51a2b
https://doi.org/10.1124/dmd.110.035550

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Induction of carbonyl reductase 1 (CBR1) expression in human lung tissues and lung cancer cells by the cigarette smoke constituent benzo[a]pyrene

Autor: Qiuying Cheng, James L. Kalabus, Javier G. Blanco, Erin G. Schuetz, Raqeeb G. Jamil

Publikováno v: Toxicology letters. 211(3)

Carbonyl reductase 1 (CBR1) reduces various xenobiotic carbonyl substrates to corresponding alcohol metabolites. Here we demonstrated that benzo[a]pyrene (B[a]P), a potent pro-carcinogen and predominant polycyclic aromatic hydrocarbon (PAH) compound

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17fb52e18f5b1b7c62813b14067862b8
https://pubmed.ncbi.nlm.nih.gov/22531821

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