Zobrazeno 1 - 10 of 25 pro vyhledávání: '"Raphaelle El-Habib"'
2
Molecular and Physicochemical Factors Governing Solubility of the HIV gp41 Ectodomain
Autor: Sara Crespillo, Francisco Conejero-Lara, Pedro L. Mateo, Bertrand Morel, Salvador Casares, Raphaelle El-Habib, Nicolas Mouz, Frank Notka, Marie G. Roger, Fadia Manssour-Triedo
Publikováno v: Biophysical journal. 111(4)
The HIV gp41 ectodomain (e-gp41) is an attractive target for the development of vaccines and drugs against HIV because of its crucial role in viral fusion to the host cell. However, because of the high insolubility of e-gp41, most biophysical and str
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df7dd2dd1cb60e795382ec209dbd373
https://pubmed.ncbi.nlm.nih.gov/27558714
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3
CCR5 or CXCR4 use influences the relationship between CD4 cell depletion, NKp44L expression and NK cytotoxicity in SHIV-infected macaques
Autor: Benoit Delache, Roger Le Grand, Frédéric Martinon, Hugues Fausther Bovendo, Vincent Vieillard, Julie Morin, Bruno Vaslin, Julien Calvo, Patrice Debré, Isabelle Picq, Patricia Brochard, Raphaelle El Habib
Publikováno v: AIDS. 22:185-192
Objective: HIV-1 infection is characterized by a progressive decline of CD4 cell count, the underlying mechanisms of which are still debated. We recently found that during HIV-1 infection, CD4 T cells overexpress a ligand of the NK activating recepto
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990a05939403737f82649d7b32bba007
https://doi.org/10.1097/qad.0b013e3282f35551
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5
A Phase 1/2 Comparative Vaccine Trial of the Safety and Immunogenicity of a CRF01_AE (Subtype E) Candidate Vaccine
Autor: Prasert Thongcharoen, Sanjay Gurunathan, Jerome H. Kim, Victoria R. Polonis, Susan W. Barnett, Chitraporn Karnasuta, Chirasak Khamboonruang, Arthur Brown, Mark de Souza, John G. McNeil, Vinai Suriyanon, Robert Paris, Silvia Ratto-Kim, Raphaelle El Habib, Deborah L. Birx, Lynn Baglyos
Publikováno v: JAIDS Journal of Acquired Immune Deficiency Syndromes. 46:48-55
Background The development of an effective HIV-1 vaccine is critical to control the pandemic. A prime-boost HIV-1 vaccine trial assessing safety and immunogenicity was conducted in Thailand as part of an evaluation of candidate regimens for a phase 3
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::febd8b518d4f8768e28b418ef419de5a
https://doi.org/10.1097/qai.0b013e3181354bd7
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6
A Randomized, Partially Blinded Phase 2 Trial of Antiretroviral Therapy, HIV‐Specific Immunizations, and Interleukin‐2 Cycles to Promote Efficient Control of Viral Replication (ACTG A5024)
Autor: J Michael, Kilby, R Pat, Bucy, Donna, Mildvan, Margaret, Fischl, Jorge, Santana-Bagur, Jeff, Lennox, Chris, Pilcher, Andrew, Zolopa, Jody, Lawrence, Richard B, Pollard, Raphaelle El, Habib, David, Sahner, Lawrence, Fox, Evgenia, Aga, Ronald J, Bosch, Ronald, Mitsuyasu
Publikováno v: The Journal of Infectious Diseases. 194:1672-1676
Strategies to limit life-long dependence on antiretroviral therapy (ART) are needed. We randomized 81 human immunodeficiency virus (HIV)-infected subjects to 4 interventional arms involving continued ART plus ALVAC vCP1452 (or placebo) with or withou
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de386bd38e0c5c83d687a5d058cfd59e
https://doi.org/10.1086/509508
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7
Comparison of Systemic and Mucosal Delivery of 2 Canarypox Virus Vaccines Expressing either HIV‐1 Genes or the Gene for Rabies Virus G Protein
Autor: Michele D. Spring, Raphaelle El Habib, Carol Smith, Jorge Flores, David H. Schwartz, Michael C. Keefer, Paul Spearman, Zina Moldoveanu, Paul A. Goepfert, Peter F. Wright, M. Juliana McElrath, Kent J. Weinhold, Yuwei Zhu, Geoffrey J. Gorse, Jiri Mestecky
Publikováno v: The Journal of Infectious Diseases. 189:1221-1231
Background Since the primary routes of human immunodeficiency type 1 (HIV-1) infection are across mucosal barriers, a randomized trial of canarypox virus-based vectors was conducted in 84 individuals, with delivery of vaccine by mucosal routes, and w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03952887210b7156b5f4faabd9fda128
https://doi.org/10.1086/382088
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8
Comparison Between Env-Specific T-Cell Epitopic Responses in HIV-1-Uninfected Adults Immunized with Combination of ALVAC-HIV(vCP205) Plus or Minus rgp160MN/LAI-2 and HIV-1-Infected Adults
Autor: Deborah L. Birx, Naomi E. Aronson, Cristin Hill, Silvia Ratto-Kim, Janelle Grimes, Lawrence D. Loomis-Price, Chevelle Williams, Jerome H. Kim, Raphaelle El Habib
Publikováno v: JAIDS Journal of Acquired Immune Deficiency Syndromes. 32:9-17
In this study, we investigated the CD4 + T-helper response induced by ALVAC-HIV(vCP205) ± rgp160MN/LAI-2 using a series of 15 overlapping amino acid peptides spanning the entire gp160MN/LAI-2 antigen. CD4 + Env-specific T-cell lines were established
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886f2859b541712aa4b8393e97f0558f
https://doi.org/10.1097/00126334-200301010-00003
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9
Preparation of Clinical‐Grade Recombinant Canarypox–Human Immunodeficiency Virus Vaccine–Loaded Human Dendritic Cells
Autor: John R. Mascola, Josephine H. Cox, Merlin L. Robb, Pierre A. Caudrelier, Raphaelle El-Habib, Silvia Ratto-Kim, Beatrice Schuler-Thurner, Wendy B. Bernstein, Jeffrey R. Currier, Michael A. Eller, Mark K. Louder, Deborah L. Birx, Ralph M. Steinman, Bruce L. Levine, Carl H. June, Sarah Schlesinger-Frankel, Mary A. Marovich
Publikováno v: The Journal of Infectious Diseases. 186:1242-1252
Preclinical data are reported that support a human immunodeficiency virus (HIV) vaccine strategy using recombinant canarypox-HIV vectors (ALVAC-HIV) to load human dendritic cells (DCs) with HIV antigens. Clinical-grade DCs were infected with good man
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b6334baf9121fb3bb3cbf34e9cef885
https://doi.org/10.1086/344302
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10
Single-chain protein mimetics of the N-terminal heptad-repeat region of gp41 with potential as anti-HIV-1 drugs
Autor: Ana Cámara-Artigas, Francisco Conejero-Lara, Bin Su, Bertrand Morel, Raphaelle El Habib, Marie G. Roger, Christophe Martin, Eva S. Cobos, Salvador Casares, Pedro L. Mateo, Nicolas Mouz, Christiane Moog, Sara Crespillo
Publikováno v: 'Proceedings of the National Academy of Sciences of the USA ', vol: 111, pages: 18207-18212 (2014)
During HIV-1 fusion to the host cell membrane, the N-terminal heptad repeat (NHR) and the C-terminal heptad repeat (CHR) of the envelope subunit gp41 become transiently exposed and accessible to fusion inhibitors or Abs. In this process, the NHR regi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89471b401f7d6aaca49a2d37697d39ab
https://pubmed.ncbi.nlm.nih.gov/25489108
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