Canagliflozin inhibits inflammasome activation in diabetic endothelial cells – Revealing a novel calcium-dependent anti-inflammatory effect of canagliflozin on human diabetic endothelial cells

Autor: Xiaoling Li, Raphaela P. Kerindongo, Benedikt Preckel, Jan-Ole Kalina, Markus W. Hollmann, Coert J. Zuurbier, Nina C. Weber

Publikováno v: Biomedicine & Pharmacotherapy, Vol 159, Iss , Pp 114228- (2023)

Background: Canagliflozin (CANA) shows anti-inflammatory and anti-oxidative effects on endothelial cells (ECs). In diabetes mellitus (DM), excessive reactive oxygen species (ROS) generation, increased intracellular calcium (Ca2+) and enhanced extrace

Externí odkaz: https://doaj.org/article/d73cc82c10a8419f99317442d2fbd5da

Hydrogen sulfide donor NaHS reduces organ injury in a rat model of pneumococcal pneumosepsis, associated with improved bio-energetic status.

Autor: Hamid Aslami, Wilco P Pulskens, Maria T Kuipers, Aafkeline P Bos, André B P van Kuilenburg, Ronald J A Wanders, Jeroen Roelofsen, Joris J T H Roelofs, Raphaela P Kerindongo, Charlotte J P Beurskens, Marcus J Schultz, Wim Kulik, Nina C Weber, Nicole P Juffermans

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e63497 (2013)

Sepsis is characterized by a generalized inflammatory response and organ failure, associated with mitochondrial dysfunction. Hydrogen sulfide donor NaHS has anti-inflammatory properties, is able to reduce metabolism and can preserve mitochondrial mor

Externí odkaz: https://doaj.org/article/66d0b4d10b034ee9a477c87e096ffef5

Empagliflozin and Dapagliflozin Reduce ROS Generation and Restore NO Bioavailability in Tumor Necrosis Factor α-Stimulated Human Coronary Arterial Endothelial Cells

Autor: Coert J. Zuurbier, Anna Homayr, Benedikt Preckel, Laween Uthman, Martin Albrecht, Pieter Koolwijk, Rio P Juni, Marleen Boomsma, Nina C. Weber, Eva L Spin, Markus W. Hollmann, Victor W.M. van Hinsbergh, Raphaela P. Kerindongo

Publikováno v: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 53(5), 865-886
Cellular Physiology and Biochemistry, Vol 53, Iss 5, Pp 865-886 (2019)
Cellular physiology and biochemistry, 53(5), 865-886. S. Karger AG
Uthman, L, Homayr, A, Juni, R P, Spin, E L, Kerindongo, R, Boomsma, M, Hollmann, M W, Preckel, B, Koolwijk, P, van Hinsbergh, V W M, Zuurbier, C J, Albrecht, M & Weber, N C 2019, ' Empagliflozin and Dapagliflozin Reduce ROS Generation and Restore NO Bioavailability in Tumor Necrosis Factor α-Stimulated Human Coronary Arterial Endothelial Cells ', Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, vol. 53, no. 5, pp. 865-886 . https://doi.org/10.33594/000000178

BACKGROUND/AIMS: Heart failure is characterized by chronic low-grade vascular inflammation, which in itself can lead to endothelial dysfunction. Clinical trials showed reductions in heart failure-related hospitalizations of type 2 diabetic patients u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::715269c9793329eac4690e6dabe3dc8a
https://research.vumc.nl/en/publications/879487b5-a1fd-4e59-b001-b8d4125c53d6

Helium postconditioning regulates expression of caveolin-1 and -3 and induces RISK pathway activation after ischaemia/reperfusion in cardiac tissue of rats

Autor: Renske Johanna Steenstra, Hemal H. Patel, Raphaela P. Kerindongo, Martin Albrecht, Markus W. Hollmann, Nina C. Weber, Benedikt Preckel, Coert J. Zuurbier, Gezina T. M. L. Oei, Moritz Flick

Publikováno v: European journal of pharmacology, 791, 718-725. Elsevier

Caveolae, lipid enriched invaginations of the plasma membrane, are epicentres of cellular signal transduction. The structural proteins of caveolae, caveolins, regulate effector pathways in anaesthetic-induced cardioprotection, including the RISK path

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6fa8bf2565caaa6d7245c3d1c47e2d9
https://doi.org/10.1016/j.ejphar.2016.10.012

Helium-Induced Early Preconditioning and Postconditioning Are Abolished in Obese Zucker Rats in Vivo

Autor: Markus W. Hollmann, Wolfgang Schlack, Nina C. Weber, Raphaela P. Kerindongo, Gezina T. M. L. Oei, Benedikt Preckel, Ragnar Huhn, Andre Heinen

Publikováno v: Journal of pharmacology and experimental therapeutics, 329(2), 600-607. American Society for Pharmacology and Experimental Therapeutics

Preconditioning is abolished in the prediabetic Zucker obese rat. It has been shown that prevention of mitochondrial permeability transition pore (mPTP) opening is involved in preconditioning by the noble gas helium. Here, we investigated: 1) whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5935f1dc12b9976525ea5eb240b78528
https://doi.org/10.1124/jpet.108.149971