Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Raphaela Fritsche-Guenther"'
Autor:
Morgan Essex, Belén Millet Pascual-Leone, Ulrike Löber, Mathias Kuhring, Bowen Zhang, Ulrike Brüning, Raphaela Fritsche-Guenther, Marta Krzanowski, Facundo Fiocca Vernengo, Sophia Brumhard, Ivo Röwekamp, Agata Anna Bielecka, Till Robin Lesker, Emanuel Wyler, Markus Landthaler, Andrej Mantei, Christian Meisel, Sandra Caesar, Charlotte Thibeault, Victor M. Corman, Lajos Marko, Norbert Suttorp, Till Strowig, Florian Kurth, Leif E. Sander, Yang Li, Jennifer A. Kirwan, Sofia K. Forslund, Bastian Opitz
Publikováno v:
npj Biofilms and Microbiomes, Vol 10, Iss 1, Pp 1-15 (2024)
Abstract The clinical course of COVID-19 is variable and often unpredictable. To test the hypothesis that disease progression and inflammatory responses associate with alterations in the microbiome and metabolome, we analyzed metagenome, metabolome,
Externí odkaz:
https://doaj.org/article/3800ac4d0de04e14b83d18bba159a41d
Autor:
Patrick J. Dörner, Harithaa Anandakumar, Ivo Röwekamp, Facundo Fiocca Vernengo, Belén Millet Pascual-Leone, Marta Krzanowski, Josua Sellmaier, Ulrike Brüning, Raphaela Fritsche-Guenther, Lennart Pfannkuch, Florian Kurth, Miha Milek, Vanessa Igbokwe, Ulrike Löber, Birgitt Gutbier, Markus Holstein, Gitta Anne Heinz, Mir-Farzin Mashreghi, Leon N. Schulte, Ann-Brit Klatt, Sandra Caesar, Sandra-Maria Wienhold, Stefan Offermanns, Matthias Mack, Martin Witzenrath, Stefan Jordan, Dieter Beule, Jennifer A. Kirwan, Sofia K. Forslund, Nicola Wilck, Hendrik Bartolomaeus, Markus M. Heimesaat, Bastian Opitz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Hospital-acquired pneumonia (HAP) is associated with high mortality and costs, and frequently caused by multidrug-resistant (MDR) bacteria. Although prior antimicrobial therapy is a major risk factor for HAP, the underlying mechanism remains
Externí odkaz:
https://doaj.org/article/41a8a643c26b41c0b66352c312b98b9b
Autor:
Jana Lücht, Raphael Seiler, Alexa Leona Herre, Liliya Brankova, Raphaela Fritsche-Guenther, Jennifer Kirwan, Dörte Huscher, Hanna Münzfeld, Felix Berger, Joachim Photiadis, Giang Tong, Katharina R. L. Schmitt
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
ObjectiveCold-inducible RNA binding Protein (CIRBP) has been shown to be a potent inflammatory mediator and could serve as a novel biomarker for inflammation. Systemic inflammatory response syndrome (SIRS) and capillary leak syndrome (CLS) are freque
Externí odkaz:
https://doaj.org/article/a721b03d05814911a1d1c18bf739fe41
Autor:
Leonard D. Kuhrt, Edyta Motta, Nirmeen Elmadany, Hannah Weidling, Raphaela Fritsche-Guenther, Ibrahim E. Efe, Olivia Cobb, Jit Chatterjee, Lucy G. Boggs, Marina Schnauß, Sebastian Diecke, Marcus Semtner, Corina Anastasaki, David H. Gutmann, Helmut Kettenmann
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 12 (2023)
Externí odkaz:
https://doaj.org/article/27ffcc79016247599283cd70ac5c43af
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract The AbsoluteIDQ p400 HR kit is a commercial product for targeted metabolomics. While the kit has been validated for human plasma and serum, adherent cell lysates have not yet been evaluated. We have optimized the detection of polar and lipid
Externí odkaz:
https://doaj.org/article/42ba3dc87f6e49cdb509e3ac058ca684
Autor:
Mario Lorenz, Raphaela Fritsche-Guenther, Cornelia Bartsch, Angelika Vietzke, Alina Eisenberger, Karl Stangl, Verena Stangl, Jennifer A. Kirwan
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1189 (2023)
Periods of low energy supply are challenging conditions for organisms and cells during fasting or famine. Although changes in nutrient levels in the blood are first sensed by endothelial cells, studies on their metabolic adaptations to diminished ene
Externí odkaz:
https://doaj.org/article/56e7c98fb29149e7bc6f3159984a14f0
Autor:
Daniela B. Dias, Raphaela Fritsche-Guenther, Friederike Gutmann, Georg N. Duda, Jennifer Kirwan, Patrina S. P. Poh
Publikováno v:
Metabolites, Vol 12, Iss 5, p 453 (2022)
The identification of endogenous metabolites has great potential for understanding the underlying tissue processes occurring in either a homeostatic or a diseased state. The application of gas chromatography-mass spectrometry (GC-MS)-based metabolomi
Externí odkaz:
https://doaj.org/article/75f3879b38034311a2629ea7b4a2af29
Autor:
Raphaela Fritsche-Guenther, Christin Zasada, Guido Mastrobuoni, Nadine Royla, Roman Rainer, Florian Roßner, Matthias Pietzke, Edda Klipp, Christine Sers, Stefan Kempa
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Abstract Metabolic reprogramming is as a hallmark of cancer, and several studies have reported that BRAF and KRAS tumors may be accompanied by a deregulation of cellular metabolism. We investigated how BRAFV600E and KRASG12V affect cell metabolism, s
Externí odkaz:
https://doaj.org/article/ba89ec86c64648e088f3642d09599e61
Autor:
Raphaela Fritsche-Guenther, Yoann Gloaguen, Anna Bauer, Tobias Opialla, Stefan Kempa, Christina A. Fleming, Henry Paul Redmond, Jennifer A. Kirwan
Publikováno v:
Metabolites, Vol 11, Iss 12, p 888 (2021)
Using manual derivatization in gas chromatography-mass spectrometry samples have varying equilibration times before analysis which increases technical variability and limits the number of potential samples analyzed. By contrast, automated derivatizat
Externí odkaz:
https://doaj.org/article/db8e5fdfd03041df90e19cc6b7d1ff98
Autor:
Anna R. Malik, Kinga Szydlowska, Karolina Nizinska, Antonino Asaro, Erwin A. van Vliet, Oliver Popp, Gunnar Dittmar, Raphaela Fritsche-Guenther, Jennifer A. Kirwan, Anders Nykjaer, Katarzyna Lukasiuk, Eleonora Aronica, Thomas E. Willnow
Publikováno v:
Cell Reports, Vol 26, Iss 10, Pp 2792-2804.e6 (2019)
Summary: VPS10P domain receptors emerge as central regulators of intracellular protein sorting in neurons with relevance for various brain pathologies. Here, we identified a role for the family member SorCS2 in protection of neurons from oxidative st
Externí odkaz:
https://doaj.org/article/549dda87d7d14f30bc0d079ad6b0d64c