Secreted Metabolome of ALS-Related hSOD1(G93A) Primary Cultures of Myocytes and Implications for Myogenesis

Autor: Roberto Stella, Raphael Severino Bonadio, Stefano Cagnin, Roberta Andreotti, Maria Lina Massimino, Alessandro Bertoli, Caterina Peggion

Publikováno v: Cells, Vol 12, Iss 23, p 2751 (2023)

Amyotrophic lateral sclerosis (ALS) is a motor neuron (MN) disease associated with progressive muscle atrophy, paralysis, and eventually death. Growing evidence demonstrates that the pathological process leading to ALS is the result of multiple alter

Externí odkaz: https://doaj.org/article/03fe34f237694d3988d36e4adf46def8

Liposomal paclitaxel induces apoptosis, cell death, inhibition of migration capacity and antitumoral activity in ovarian cancer

Autor: Raquel Santos Faria, Luiza Ianny de Lima, Raphael Severino Bonadio, João Paulo Figueiró Longo, Marjorie Coimbra Roque, João Nunes de Matos Neto, Sergio Enrique Moya, Mônica Cristina de Oliveira, Ricardo Bentes Azevedo

Publikováno v: Biomedicine & Pharmacotherapy, Vol 142, Iss , Pp 112000- (2021)

The main goal of this study is to evaluate the efficacy of the paclitaxel (PTX) drug formulated with a liposomal nanosystem (L-PTX) in a peritoneal carcinomatosis derived from ovarian cancer. In vitro cell viability studies with the human ovarian can

Externí odkaz: https://doaj.org/article/24cfd717c26248fb88514df753567e03

Regulation of Endoplasmic Reticulum-Mitochondria Tethering and Ca

Autor: Alessandro Bertoli, Tito Calì, Maria Lina Massimino, Caterina Peggion, Raphael Severino Bonadio, Stefano Cagnin, Raffaele Lopreiato, Federica Lia

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 21
International Journal of Molecular Sciences, Vol 22, Iss 11853, p 11853 (2021)

Mitochondria–ER contacts (MERCs), tightly regulated by numerous tethering proteins that act as molecular and functional connections between the two organelles, are essential to maintain a variety of cellular functions. Such contacts are often compr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a13bcebc63e35c8b36985dd5996edb
https://pubmed.ncbi.nlm.nih.gov/34769284

Perturbations of the Proteome and of Secreted Metabolites in Primary Astrocytes from the hSOD1(G93A) ALS Mouse Model

Autor: Maria Lina Massimino, Alessandro Bertoli, Raphael Severino Bonadio, Roberto Stella, Caterina Peggion, Stefano Cagnin

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 7028, p 7028 (2021)
Volume 22
Issue 13

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease whose pathophysiology is largely unknown. Despite the fact that motor neuron (MN) death is recognized as the key event in ALS, astrocytes dysfunctionalities and neuroinfla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f49d2683d428d26ea2f09361870ed6
https://pubmed.ncbi.nlm.nih.gov/34209958

Melittin sensitizes skin squamous carcinoma cells to 5-fluorouracil by affecting cell proliferation and survival

Autor: Willie O. Pinheiro, Graziella Anselmo Joanitti, Raphael Severino Bonadio, Alicia S. Ombredane, Laise Rodrigues de Andrade, Ricardo Bentes Azevedo

Publikováno v: Experimental dermatologyREFERENCES. 30(5)

Combined 5-fluorouracil (5-FU) and melittin (MEL) is believed to enhance cytotoxic effects on skin squamous cell carcinoma (SCC). However, the rationale underlying cytotoxicity is fundamentally important for a proper design of combination chemotherap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ffebbeb4bdac376bc13732c9f593b7
https://pubmed.ncbi.nlm.nih.gov/33523510