Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Raphael S. Haider"'
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116575- (2024)
Sepsis is characterized as life-threatening organ dysfunction caused by a dysregulated host response to an infection. Despite numerous clinical trials that addressed this syndrome, there is still no causative treatment available to dampen its severit
Externí odkaz:
https://doaj.org/article/010e0b30ea494d14a19a8f95cf48134c
Autor:
Raphael S. Haider, Edda S. F. Matthees, Julia Drube, Mona Reichel, Ulrike Zabel, Asuka Inoue, Andy Chevigné, Cornelius Krasel, Xavier Deupi, Carsten Hoffmann
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Here the authors present improved intramolecular sensors for β-arrestin2 and 1, which enable assessment of conformational changes of both isoforms in living cells. These reveal that the same GPCR induces differential conformational rearrangements th
Externí odkaz:
https://doaj.org/article/c788b6ac74db47fe8176035c251fe6d0
Autor:
Marta Sánchez-Soto, Noelia M. Boldizsar, Kayla A. Schardien, Nora S. Madaras, Blair K. A. Willette, Laura R. Inbody, Christopher Dasaro, Amy E. Moritz, Julia Drube, Raphael S. Haider, R. Benjamin Free, Carsten Hoffman, David R. Sibley
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1552 (2023)
The D2 dopamine receptor (D2R) signals through both G proteins and β-arrestins to regulate important physiological processes, such as movement, reward circuitry, emotion, and cognition. β-arrestins are believed to interact with G protein-coupled re
Externí odkaz:
https://doaj.org/article/a4efa938f10740ff9782ac55fdd0a957
Autor:
Julia Leonhardt, Raphael S. Haider, Christoph Sponholz, Silke Leonhardt, Julia Drube, Katrin Spengler, Diana Mihaylov, Sophie Neugebauer, Michael Kiehntopf, Nevin A. Lambert, Andreas Kortgen, Tony Bruns, Frank Tacke, Carsten Hoffmann, Michael Bauer, Regine Heller
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 1, Pp 25-40 (2021)
Background & Aims: Retention of bile acids in the blood is a hallmark of liver failure. Recent studies have shown that increased serum bile acid levels correlate with bacterial infection and increased mortality. However, the mechanisms by which circu
Externí odkaz:
https://doaj.org/article/f2898bb220504471a55ccd6030fbf158
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane receptors and their signal transduction is tightly regulated by GPCR kinases (GRKs) and β-arrestins. In this review, we discuss novel aspects of the regulatory GRK/β-a
Externí odkaz:
https://doaj.org/article/1f8ff177f27f4e7cbd8d7a3986f7b2dd
Autor:
Xavier Deupi, Philipp Berger, Eshita Mutt, Aurélien Rizk, Martin K. Ostermaier, Jonas Mühle, Christian Peterhans, Jörg Standfuss, Florian Wilhelm, Raphael S. Haider, Gebhard F. X. Schertler
Publikováno v:
Scientific Reports
Scientific Reports, 9
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports, 9
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Arrestin-1 desensitizes the activated and phosphorylated photoreceptor rhodopsin by forming transient rhodopsin−arrestin-1 complexes that eventually decay to opsin, retinal and arrestin-1. Via a multi-dimensional screening setup, we identified and
Publikováno v:
The Structural Basis of Arrestin Functions ISBN: 9783319575520
The structural basis of arrestin functions
The structural basis of arrestin functions
The molecular mechanism of arrestin–G protein-coupled receptor (GPCR ) complex formation has been analyzed using inter alia spectroscopic, mutagenesis and structure determination methods. The latest crystal structure elucidating one conformation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::659ae0ca5fa315cb5f54e322df11f321
https://doi.org/10.1007/978-3-319-57553-7_7
https://doi.org/10.1007/978-3-319-57553-7_7