CTIP2, une protéine multifonctionnelle

Autor: Raphael Riclet, Thomas Cherrier, Olivier Rohr, Christian Schwartz, Valentin Le Douce

Publikováno v: médecine/sciences
médecine/sciences, EDP Sciences, 2014, 30 (8-9), pp.797-802. ⟨10.1051/medsci/20143008019⟩

The transcription factor CTIP2 (BCL11B) is a multifunctional protein involved in numerous cell physiological processes. To date, many molecular mechanisms underlying this process have been discovered, which highlighted the importance of the epigeneti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974b081cb0cca49f5fb635c2aa80cb52
https://doi.org/10.1051/medsci/20143008019

Bcl11b, a transcriptional repressor: Its role in cardiac homeostasis and remodeling

Autor: Zhenlin Li, P. Liu, Ara Parlakian, Olivier Rohr, Nathalie Mougenot, Pedro Bausero, M.T. Daher, Raphael Riclet

Publikováno v: Archives of Cardiovascular Diseases Supplements. 10:242

Introduction Diverse forms of cardiomyopathies result in cardiac compensatory remodeling that may progress to ventricular dilation and heart failure. This remodeling is characterized by an increase in the size of cardiomyocytes associated with elevat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d081d0519172eb1b1f87f1e34fef81ea
https://doi.org/10.1016/j.acvdsp.2018.02.145

0441: Bcl11b/CTIP2, a newly identified transcriptional repressor: its role in cardiac hypertrophy and commitment of cardiac stem cells

Autor: Roy El-Koury, Olivier Rohr, Tsolere Arakelian, Ara Parlakian, Pedro Bausero, Li Zhenlin, Raphael Riclet

Publikováno v: Archives of Cardiovascular Diseases Supplements. 6

Bcl11b/CTIP2, a zinc finger transcriptional repressor, interacts with the RNApolymeraseII regulatory complex pTefb and exert an inhibitory action on it. It is also implicated in the regulation of stem cells. Genetic variations in its locus is associa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70e2b49bb0cee54b80290a182d48c253

CTIP2 is a negative regulator of P-TEFb

Autor: Siavash K. Kurdistani, Thomas Cherrier, Jean-Christophe Paillart, Pedro Bausero, Yannick Goumon, Benoît Van Driessche, Xavier Graña, Wasim Abbas, Carine Van Lint, Olivier Rohr, Mathias Mericskay, Ermanno Candolfi, Arndt Benecke, Georges Herbein, Raphael Riclet, Ara Parlakian, Céline Marban, Christian Schwartz, Valentin Le Douce, Sebastian Eilebrecht, Franck Dequiedt

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (31), pp.12655-12660. ⟨10.1073/pnas.1220136110⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2013, 110 (31), pp.12655-12660. ⟨10.1073/pnas.1220136110⟩

International audience; The positive transcription elongation factor b (P-TEFb) is involved in physiological and pathological events including inflammation, cancer, AIDS, and cardiac hypertrophy. The balance between its active and inactive form is ti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cffb82b543d93e01cb1f34c269a58274
https://hal.archives-ouvertes.fr/hal-01544149