Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Raphael Pineau"'
Autor:
Raphael Pineau, Pierre Jean Le Reste, Tony Avril, Ulrich Jarry, Eric Chevet, Diana Pelizzari-Raymundo
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103304- (2024)
Summary: In cancer research, murine models play a crucial role as highly valuable preclinical tools. Here, we present a protocol to generate a murine model of glioblastoma through the direct intracranial injection of tumor cells. We describe steps fo
Externí odkaz:
https://doaj.org/article/d6c8208a6d204dbaa5b17d57b18891d6
Autor:
Diana Pelizzari-Raymundo, Dimitrios Doultsinos, Raphael Pineau, Chloé Sauzay, Thodoris Koutsandreas, Timothy Langlais, Antonio Carlesso, Elena Gkotsi, Luc Negroni, Tony Avril, Aristotelis Chatziioannou, Eric Chevet, Leif A. Eriksson, Xavier Guillory
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106687- (2023)
Summary: Inositol-requiring enzyme 1 (IRE1) is a major mediator of the unfolded protein response (UPR), which is activated upon endoplasmic reticulum (ER) stress. Tumor cells experience ER stress due to adverse microenvironmental cues, a stress overc
Externí odkaz:
https://doaj.org/article/ec4db961d77f43c39ac1a07754c5bca7
Autor:
Lindsay S. Cooley, Justine Rudewicz, Wilfried Souleyreau, Andrea Emanuelli, Arturo Alvarez-Arenas, Kim Clarke, Francesco Falciani, Maeva Dufies, Diether Lambrechts, Elodie Modave, Domitille Chalopin-Fillot, Raphael Pineau, Damien Ambrosetti, Jean-Christophe Bernhard, Alain Ravaud, Sylvie Négrier, Jean-Marc Ferrero, Gilles Pagès, Sebastien Benzekry, Macha Nikolski, Andreas Bikfalvi
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-21 (2021)
Abstract Background Renal Cell Carcinoma (RCC) is difficult to treat with 5-year survival rate of 10% in metastatic patients. Main reasons of therapy failure are lack of validated biomarkers and scarce knowledge of the biological processes occurring
Externí odkaz:
https://doaj.org/article/cee420b826cb4bfbb98850145497e573
Autor:
Thomas Daubon, Céline Léon, Kim Clarke, Laetitia Andrique, Laura Salabert, Elodie Darbo, Raphael Pineau, Sylvaine Guérit, Marlène Maitre, Stéphane Dedieu, Albin Jeanne, Sabine Bailly, Jean-Jacques Feige, Hrvoje Miletic, Marco Rossi, Lorenzo Bello, Francesco Falciani, Rolf Bjerkvig, Andréas Bikfalvi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Thrombospondin-1 (THSB1) is a component of the ECM with a role in regulating cancer development and tumour vasculature. Here, the authors show that TGF-beta-induced THBS1 expression contributes to the invasive behaviour of GBM cells and promotes resi
Externí odkaz:
https://doaj.org/article/0213114feac44243930602814fc59d30
Autor:
Delphine Fessart, Charlotte Domblides, Tony Avril, Leif A Eriksson, Hugues Begueret, Raphael Pineau, Camille Malrieux, Nathalie Dugot-Senant, Carlo Lucchesi, Eric Chevet, Frederic Delom
Publikováno v:
eLife, Vol 5 (2016)
The extracellular matrix (ECM) plays an instrumental role in determining the spatial orientation of epithelial polarity and the formation of lumens in glandular tissues during morphogenesis. Here, we show that the Endoplasmic Reticulum (ER)-resident
Externí odkaz:
https://doaj.org/article/3876518ea92442c383684c20fc26b282
Autor:
Michel Moenner, Andréas Bikfalvi, Eric Chevet, Randal J. Kaufman, Josephine Nalbantoglu, Raphael Pineau, Marion Bouchecareilh, Duc Thang Nguyen, Patrick Auguste, Benjamin Drogat
In solid tumors, cancer cells subjected to ischemic conditions trigger distinct signaling pathways contributing to angiogenic stimulation and tumor development. Characteristic features of tumor ischemia include hypoxia and glucose deprivation, leadin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e99ae6e94f9d12206ce541182fc1efe2
https://doi.org/10.1158/0008-5472.c.6494906.v1
https://doi.org/10.1158/0008-5472.c.6494906.v1
Autor:
Andreas Bikfalvi, Hervé Prats, Martin Hagedorn, Abdel-Majid Khatib, Abderrahim Lomri, Kim Clarke, Shih-Che Sue, Vincent Castronovo, Martin Schilling, Raphael Pineau, Anne Couvelard, Harald Wodrich, Fabienne Rayne, Thomas Daubon, Renaud Grepin, Marie Sire, Laurent Dumartin, Florence Darlot, Fabienne Soulet, Clotilde Billottet, Alexandre Dubrac, Kevin Boyé, Jessica Baud, Cathy Quemener
The CXCL4 paralog CXCL4L1 is a less studied chemokine that has been suggested to exert an antiangiogenic function. However, CXCL4L1 is also expressed in patient tumors, tumor cell lines, and murine xenografts, prompting a more detailed analysis of it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1371f3e46843ba67f4734219bc52110
https://doi.org/10.1158/0008-5472.c.6507866
https://doi.org/10.1158/0008-5472.c.6507866
Autor:
Andreas Bikfalvi, Hervé Prats, Martin Hagedorn, Abdel-Majid Khatib, Abderrahim Lomri, Kim Clarke, Shih-Che Sue, Vincent Castronovo, Martin Schilling, Raphael Pineau, Anne Couvelard, Harald Wodrich, Fabienne Rayne, Thomas Daubon, Renaud Grepin, Marie Sire, Laurent Dumartin, Florence Darlot, Fabienne Soulet, Clotilde Billottet, Alexandre Dubrac, Kevin Boyé, Jessica Baud, Cathy Quemener
Characterization of CXCR3 overexpression in MIA PaCa-2 cells in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c06e7aeea613ebd6344e60236ac17d9
https://doi.org/10.1158/0008-5472.22409819
https://doi.org/10.1158/0008-5472.22409819
Autor:
Andreas Bikfalvi, Hervé Prats, Martin Hagedorn, Abdel-Majid Khatib, Abderrahim Lomri, Kim Clarke, Shih-Che Sue, Vincent Castronovo, Martin Schilling, Raphael Pineau, Anne Couvelard, Harald Wodrich, Fabienne Rayne, Thomas Daubon, Renaud Grepin, Marie Sire, Laurent Dumartin, Florence Darlot, Fabienne Soulet, Clotilde Billottet, Alexandre Dubrac, Kevin Boyé, Jessica Baud, Cathy Quemener
Supplemental Material and Method section
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e57d2d7a57c89922035113ebf24c54
https://doi.org/10.1158/0008-5472.22409813
https://doi.org/10.1158/0008-5472.22409813
Autor:
Eric Chevet, Martin E. Fernandez-Zapico, Frédéric Saltel, Jean Rosenbaum, Fausto J. Rodriguez, Wenting Wu, Keith Anderson, Jann N. Sarkaria, Michael Hallett, Said Taouji, Sara J.C. Gosline, Hugues Loiseau, Anne Vital, Nathalie Dugot-Senant, Gaelle Cubel, Sandrine Loriot, Chantal Combe, Maylis Delugin, Arisa Higa, Raphael Pineau, Stephanie Lhomond, Marion Bouchecareilh, Nicolas Dejeans, Olivier Pluquet
PDF file - 809K, Table S1 List of genes deregulated in IRE1_DN cells. Table S2 Potential IRE1 cleavage sites on PER1 mRNA. Table S3 Characteristics of human glioma biopsies used in this study. Table S4 Primer Pairs used for PCR and qPCR studies. Tabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3148a3886fb5c5b077d0c642e65e86f6
https://doi.org/10.1158/0008-5472.22398107.v1
https://doi.org/10.1158/0008-5472.22398107.v1