Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Raphael P. B. Jacquat"'
Autor:
Georg Krainer, Raphael P. B. Jacquat, Matthias M. Schneider, Timothy J. Welsh, Jieyuan Fan, Quentin A. E. Peter, Ewa A. Andrzejewska, Greta Šneiderienė, Magdalena A. Czekalska, Hannes Ausserwoeger, Lin Chai, William E. Arter, Kadi L. Saar, Therese W. Herling, Titus M. Franzmann, Vasilis Kosmoliaptsis, Simon Alberti, F. Ulrich Hartl, Steven F. Lee, Tuomas P. J. Knowles
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The physical characterization of proteins in terms of their sizes, interactions, and assembly states is key to understanding their biological function and dysfunction. However, this has remained a difficult task because proteins are often hi
Externí odkaz:
https://doaj.org/article/a359ec4607614996aebacbbb2897fd7b
Autor:
Tuomas P. J. Knowles, Therese W. Herling, Tadas Kartanas, Quentin Peter, Raphael P. B. Jacquat, Pavan K. Challa
Publikováno v:
The Journal of Physical Chemistry B. 126:8913-8920
Living systems are characterized by their spatially highly inhomogeneous nature which is susceptible to modify fundamentally the behavior of biomolecular species, including the proteins that underpin biological functionality in cells. Spatial gradien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb4cdb53ebe3d20e2ea122fe1478e989
https://doi.org/10.1021/acs.jpcb.2c04029
https://doi.org/10.1021/acs.jpcb.2c04029
Autor:
Catherine K. Xu, Georg Meisl, Ewa A. Andrzejewska, Georg Krainer, Alexander J. Dear, Marta Castellana-Cruz, Soma Turi, Irina A. Edu, Giorgio Vivacqua, Raphaël P. B. Jacquat, William E. Arter, Maria Grazia Spillantini, Michele Vendruscolo, Sara Linse, Tuomas P. J. Knowles
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Oligomeric species arising during the aggregation of α-synuclein are implicated as a major source of toxicity in Parkinson’s disease, and thus a major potential drug target. However, both their mechanism of formation and role in aggregati
Externí odkaz:
https://doaj.org/article/a4d1104eb0184ade8af0b5e5b4fb8983
Autor:
David B. Morse, Tuomas P. J. Knowles, Yufan Xu, Daniele Vigolo, Shuyuan Zhang, Yi Shen, Raphael P. B. Jacquat
Publikováno v:
Small (Weinheim an der Bergstrasse, Germany). 16(32)
3D scaffolds in the form of hydrogels and microgels have allowed for more native cell-culture systems to be developed relative to flat substrates. Native biological tissues are, however, usually spatially inhomogeneous and anisotropic, but regulating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef64930c5dc64cb320714581cea4b810
https://pubmed.ncbi.nlm.nih.gov/32529798
https://pubmed.ncbi.nlm.nih.gov/32529798
Autor:
Raphael P. B. Jacquat, Matthias Schneider, Alison Ilsley, Itzel Condado Morales, Heike Fiegler, Catherine K. Xu, Tuomas P. J. Knowles, Chryssa Zografou, Georg Meisl, Didier Trono, Marc Emmenegger, Viola Denninger, Vasilis Kosmoliaptsis, Adriano Aguzzi, Manuela R Zimmermann, Lidia Madrigal, Sebastian Fiedler, Priscilla Turelli, Beat M. Frey
Publikováno v:
Life Science Alliance
Funder: Herchel Smith Fund
Funder: St John’s College Cambridge
Funder: Centre for Misfolding Diseases, Cambridge
Funder: Swiss FCS and the Forschungskredit of the University of Zurich
Funder: Frances and Augustus Newman Foundati
Funder: St John’s College Cambridge
Funder: Centre for Misfolding Diseases, Cambridge
Funder: Swiss FCS and the Forschungskredit of the University of Zurich
Funder: Frances and Augustus Newman Foundati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81aad5fc5b54a8a2051d696ba0fca7b0
https://doi.org/10.26508/lsa.202101270
https://doi.org/10.26508/lsa.202101270
Autor:
Tuomas P. J. Knowles, Raphael P. B. Jacquat, David B. Morse, Yufan Xu, Shuyuan Zhang, Daniele Vigolo, Yi Shen
Publikováno v:
Small. 16:2070178
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd4f3a1fe6cca590f44de1fcbec0f2ef
https://doi.org/10.1002/smll.202070178
https://doi.org/10.1002/smll.202070178
Autor:
Hong-Ze Gang, Ru-Qiang Ye, Kadi L. Saar, Liu Hong, Tuomas P. J. Knowles, Lingling Kong, Raphael P. B. Jacquat, Bo-Zhong Mu, Aviad Levin
Publikováno v:
Interface focus. 7(6)
Many biological molecules are by their nature amphiphilic and have the ability to act as surfactants, stabilizing interfaces between aqueous and immiscible oil phases. In this paper, we explore the adsorption kinetics of surfactin, a naturally occurr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b3d646eebc7c067a68b3450e37a3182
https://pubmed.ncbi.nlm.nih.gov/29147556
https://pubmed.ncbi.nlm.nih.gov/29147556
Autor:
Georg Krainer, Kadi L. Saar, William E. Arter, Timothy J. Welsh, Magdalena A. Czekalska, Raphaël P. B. Jacquat, Quentin Peter, Walther C. Traberg, Arvind Pujari, Akhila K. Jayaram, Pavankumar Challa, Christopher G. Taylor, Lize-Mari van der Linden, Titus Franzmann, Roisin M. Owens, Simon Alberti, David Klenerman, Tuomas P. J. Knowles
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
There are limitations with current protein sensing methods. Here the authors report DigitISA, a digital immunosensor assay based on microchip electrophoretic separation and single-molecule detection that enables quantitation of protein biomarkers in
Externí odkaz:
https://doaj.org/article/1dd14b1c42c546e0b4a6295b18856433