Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Raphael Nudelman"'
Autor:
Martin A. Hayes, Nenad Manevski, James Harvey, Chuang Lu, Lars Weidolf, Pascale Jacques, Joel P. Bercu, Andreas Brink, Susanne Glowienke, Andrew Teasdale, Raphael Nudelman, Jenny Ottosson, Bruce Trela, Ron Ogilvie, Wolfgang Muster, Thomas Andersson
Publikováno v:
Regulatory Toxicology and Pharmacology. 110:104524
Regulatory Guidance documents ICH Q3A (R2) and ICH Q3B (R2) state that "impurities that are also significant metabolites present in animal and/or human studies are generally considered qualified". However, no guidance is provided regarding data requi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e227eb59c059fabd722211e1ecd5ff2
https://doi.org/10.1016/j.yrtph.2019.104524
https://doi.org/10.1016/j.yrtph.2019.104524
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 13:358-365
Fluorescence resonance energy transfer substrates were designed and tested as substrates for ADAM9. The donor/quencher pair used were 5-carboxy fluorescein (Fam) and 4-(4-dimethyl-aminophenylazo)benzoyl (Dabcyl) since they have been well studied sens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36488b12cf259ca9db53c737a96a79be
https://doi.org/10.2174/138620710791054259
https://doi.org/10.2174/138620710791054259
Publikováno v:
Nature Clinical Practice Rheumatology. 4:300-309
The success of agents that inhibit tumor necrosis factor (TNF), such as infliximab, adalimumab and etanercept, has led to a desire for orally available small molecules that have a better safety profile and are less costly to produce than current agen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b283b9097ad9681d285b6d7a1a5c01b
https://doi.org/10.1038/ncprheum0797
https://doi.org/10.1038/ncprheum0797
Autor:
Raphael Nudelman, Kunal Merchant, Alfred Hausladen, Joseph DeAngelo, Jonathan S. Stamler, Wayne F. Beyer, Sung Oog Kim, Teresa Keng
Publikováno v:
Cell. 109(3):383-396
Redox regulation has been perceived as a simple on-off switch in proteins (corresponding to reduced and oxidized states). Using the transcription factor OxyR as a model, we have generated, in vitro, several stable, posttranslational modifications of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e02a1901b4f63e6d990d9224514e31
Publikováno v:
Journal of Medicinal Chemistry. 41:1671-1678
Biomimetic analogues 1 of the microbial siderophore (iron carrier) ferrichrome were labeled via piperazine with various fluorescent markers at a site not interfering with iron binding or receptor recognition (compounds 10-12). These iron carriers wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b8b469a158fba0879a4fdb19c70107
https://doi.org/10.1021/jm970581b
https://doi.org/10.1021/jm970581b
Autor:
Abraham J. Domb, Raphael Nudelman
Publikováno v:
Biomaterials. 16:319-323
The hydrolysis and elimination processes of biopolyanhydrides has been studied using a polymer series of linear aliphatic diacids. This polymer series degrade into their monomer counterparts at about the same rate but differ in the water solubility o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1814e31572f4701bc1dbbd345601824e
https://doi.org/10.1016/0142-9612(95)93260-k
https://doi.org/10.1016/0142-9612(95)93260-k
Publikováno v:
Pharmaceutical Research. 11:865-868
Chemical reactions between drugs containing reactive amines with hydrolyzable polymers in buffer solutions were investigated. Phenylalkylamines with increasing nucleophilic reactivity were used as model drugs. Solutions of phenylalkylamines were reac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92600c1c0f92b34c5d6e9bb18ea86519
https://doi.org/10.1023/a:1018985909777
https://doi.org/10.1023/a:1018985909777
Publikováno v:
Nature Cell Biology. 3:E46-E48
Nitric oxide regulates a broad functional spectrum of proteins by S-nitrosylation. Specificity is conferred by acid–base and hydrophobic motifs that target critical cysteine residues and by protein–protein interactions that confine the signals in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::327880837f424459319d7fc0ea4cdd9d
https://doi.org/10.1038/35055152
https://doi.org/10.1038/35055152
Autor:
Oren M. Becker, Merav Fichman, Alexander Heifetz, Chen Dongli, Michael Kauffman, Dhanoa Dale S, Yael Marantz, Srinivasa Rao Cheruku, Sharon Shacham, Raphael Nudelman, Silvia Noiman, Anurag Sharadendu, Pradyumna Mohanty
Publikováno v:
Journal of medicinal chemistry. 49(11)
We report the discovery of a novel, potent, and selective amidosulfonamide nonazapirone 5-HT1A agonist for the treatment of anxiety and depression, which is now in Phase III clinical trials for generalized anxiety disorder (GAD). The discovery of 20m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31e77b183143d1a3fe29804546d7fdf
https://pubmed.ncbi.nlm.nih.gov/16722631
https://pubmed.ncbi.nlm.nih.gov/16722631
Autor:
Raphael Nudelman, Thomas M. Bashore, Yuh-Chin T. Huang, Timothy J. McMahon, Abigail Krichman, Martin P Moya, Andrew J. Gow, Jonathan S. Stamler, Claude A. Piantadosi, Robert M. Califf, Victor F. Tapson, Yun Yan, Gregory S. Ahearn, Benjamin P. Luchsinger, David J. Singel
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 102(41)
The mechanism by which hypoxia [low partial pressure of O 2 (pO 2 )] elicits signaling to regulate pulmonary arterial pressure is incompletely understood. We considered the possibility that, in addition to its effects on smooth muscle, hypoxia may in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0ca8a378c9268f20136c4c4cc2a3256
https://pubmed.ncbi.nlm.nih.gov/16203976
https://pubmed.ncbi.nlm.nih.gov/16203976