Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Raphael Lemaire"'
Autor:
Sergio Piñeiro-Hermida, Paula Martínez, Giuseppe Bosso, Juana María Flores, Sarita Saraswati, Jane Connor, Raphael Lemaire, Maria A. Blasco
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Telomere dysfunction induced by TRF1 depletion in fibroblasts, club and basal cells did not lead to interstitial lung fibrosis, underscoring alveolar type II cells as the relevant cell type in pulmonary fibrosis.
Externí odkaz:
https://doaj.org/article/164bee17bc524cb09204db0d0f952f50
Autor:
Sarah A Pendergrass, Everett Hayes, Giuseppina Farina, Raphael Lemaire, Harrison W Farber, Michael L Whitfield, Robert Lafyatis
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12106 (2010)
Pulmonary arterial hypertension (PAH) is a common complication for individuals with limited systemic sclerosis (lSSc). The identification and characterization of biomarkers for lSSc-PAH should lead to less invasive screening, a better understanding o
Externí odkaz:
https://doaj.org/article/f80fd548188a45aa912e34a858680164
Autor:
Weiguang Zhao, Ximing Xiong, Roland Kolbeck, G.J. Criner, Kamelia Zerrouki, Charles Brown, Aaron A Berlin, Christopher T. Cottage, Jane Connor, Jennifer Kearley, Raphael Lemaire, Norman C. Peterson, Annik Migneault, Anna Huntley
Publikováno v:
Communications Biology
Communications Biology, Vol 2, Iss 1, Pp 1-11 (2019)
Communications Biology, Vol 2, Iss 1, Pp 1-11 (2019)
Senescence is a mechanism associated with aging that alters tissue regeneration by depleting the stem cell pool. Chronic obstructive pulmonary disease (COPD) displays hallmarks of senescence, including a diminished stem cell population. DNA damage fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e41ac28b4e63c0793ede82c72a7e143
https://doi.org/10.1038/s42003-019-0532-1
https://doi.org/10.1038/s42003-019-0532-1
Autor:
Robert Lafyatis, Stephen H. Clark, Chelsea M. Burgwin, Minghua Wu, Carol M. Artlett, Adam Harris, Elizabeth P. Blankenhorn, Matthew B. Greenblatt, Kristen B. Long, John Varga, Jun Wei, Zhenghui Li, Michael L. Whitfield, Jennifer L. Sargent, Antonios O. Aliprantis, Jaclyn N. Taroni, Raphael Lemaire
Publikováno v:
Arthritis & Rheumatology. 68:2003-2015
Objective Understanding the pathogenesis of systemic sclerosis (SSc) is confounded by considerable disease heterogeneity. Animal models of SSc that recapitulate distinct subsets of disease at the molecular level have not been delineated. We applied i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d57ab25f07200f424d9ed78008463b29
https://doi.org/10.1002/art.39658
https://doi.org/10.1002/art.39658
Autor:
Robert Lafyatis, Isabelle de-Mendez, Anthony J. Coyle, Ronald Herbst, Meggan Czapiga, Raphael Lemaire, Timothy Burwell, Jane Connor, Julie Bakken, Tracy Delaney, Hong Sun, Marlon Rebelatto, Lily Cheng
Publikováno v:
Arthritis & Rheumatology. 68:473-483
Objective Systemic sclerosis (SSc) is a fibrotic disease characterized by an obliterative vasculopathy with thrombosis and impairment of the coagulation–fibrinolysis balance. Plasminogen activator inhibitor 1 (PAI-1) is the major inhibitor of profi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b9f4fb9b8cba4f01b42501d30e3c318
https://doi.org/10.1002/art.39443
https://doi.org/10.1002/art.39443
Publikováno v:
Microscopy and Microanalysis. 26:608-608
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14a388a1dfad647fefba200538c07e55
https://doi.org/10.1017/s1431927620015263
https://doi.org/10.1017/s1431927620015263
Autor:
Sarah A. Pendergrass, J. Matthew Mahoney, Raphael Lemaire, Robert Lafyatis, Ian P. Francis, Michael L. Whitfield
Publikováno v:
Journal of Investigative Dermatology. 132(5):1363-1373
Skin biopsy gene expression was analyzed by DNA microarray from 13 diffuse cutaneous systemic sclerosis (dSSc) patients enrolled in an open-label study of rituximab, 9 dSSc patients not treated with rituximab, and 9 healthy controls. These data recap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d4c5ee5d8e3134d7a7a425acd4d8c12
Autor:
Michael DiMarzio, Michael L. Whitfield, Robert Lafyatis, Raphael Lemaire, Julie Bayle, Sarah A. Pendergrass, Ausra Milano, Giuseppina Farina
Publikováno v:
Journal of Investigative Dermatology. 130(6):1514-1523
Abnormal fibrillinogenesis is associated with connective tissue disorders (CTDs), including Marfan syndrome (MFS), systemic sclerosis (SSc) and Tight-skin (Tsk) mice. We have previously shown that TGF-beta and Wnt stimulate fibrillin-1 assembly and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb6204a418ee670904943e1fb7b53d1
Publikováno v:
Arthritis & Rheumatism. 62:580-588
Objective Improved outcome measures in systemic sclerosis (SSc) are critical to finding active therapeutics for this disease. The modified Rodnan skin thickness score (MRSS) is the current standard for evaluating skin disease in SSc, but it is not co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb9ea6eed21b361ca78e1f43afec506b
https://doi.org/10.1002/art.27220
https://doi.org/10.1002/art.27220
Autor:
Robert Lafyatis, Raphael Lemaire, Julie Bayle, Kimberly A. Jacobsen, Jennifer L Fitch, Rajiv Kumar
Publikováno v:
Journal of Investigative Dermatology. 128(4):871-881
Systemic sclerosis (SSc) is a complex human disorder characterized by progressive skin fibrosis. To better understand the molecular basis of dermal fibrosis in SSc, we analyzed microarray gene expression in skin of the Tight-skin (Tsk) mouse, an anim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4b95c7c5cd75fc97329fb4a27b0dfb3