Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Raphael Josef Eberle"'
1
Akademický článek
The search for an antiviral lead molecule to combat the neglected emerging Oropouche virus
Autor: Rafaela dos Santos Peinado, Marielena Vogel Saivish, Gabriela de Lima Menezes, Umberto Laino Fulco, Roosevelt Alves da Silva, Karolina Korostov, Raphael Josef Eberle, Paulo A. Melo, Maurício Lacerda Nogueira, Carolina Colombelli Pacca, Raghuvir Krishnaswamy Arni, Mônika Aparecida Coronado
Publikováno v: Current Research in Microbial Sciences, Vol 6, Iss , Pp 100238- (2024)
Oropouche virus (OROV) is a member of the Peribunyaviridae family and the causative agent of a dengue-like febrile illness transmitted by mosquitoes. Although mild symptoms generally occur, complications such as encephalitis and meningitis may develo
Externí odkaz: https://doaj.org/article/ff433e66e08448f380bf92b30d91d47b
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2
Akademický článek
Acridones as promising drug candidates against Oropouche virus
Autor: Marielena Vogel Saivish, Gabriela de Lima Menezes, Roosevelt Alves da Silva, Leticia Ribeiro de Assis, Igor da Silva Teixeira, Umberto Laino Fulco, Clarita Maria Secco Avilla, Raphael Josef Eberle, Igor de Andrade Santos, Karolina Korostov, Mayara Lucia Webber, Gislaine Celestino Dutra da Silva, Maurício Lacerda Nogueira, Ana Carolina Gomes Jardim, Luis Octavio Regasin, Mônika Aparecida Coronado, Carolina Colombelli Pacca
Publikováno v: Current Research in Microbial Sciences, Vol 6, Iss , Pp 100217- (2024)
Oropouche virus (OROV) is an emerging vector-borne arbovirus found in South America that causes Oropouche fever, a febrile infection similar to dengue fever. It has a high epidemic potential, causing illness in over 500,000 cases diagnosed since the
Externí odkaz: https://doaj.org/article/054cad743f4a4a31976eae8a4bc69e41
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3
Akademický článek
Tau protein aggregation associated with SARS-CoV-2 main protease.
Autor: Raphael Josef Eberle, Mônika Aparecida Coronado, Ian Gering, Simon Sommerhage, Karolina Korostov, Anja Stefanski, Kai Stühler, Victoria Kraemer-Schulien, Lara Blömeke, Oliver Bannach, Dieter Willbold
Publikováno v: PLoS ONE, Vol 18, Iss 8, p e0288138 (2023)
The primary function of virus proteases is the proteolytic processing of the viral polyprotein. These enzymes can also cleave host cell proteins, which is important for viral pathogenicity, modulation of cellular processes, viral replication, the def
Externí odkaz: https://doaj.org/article/85e1f6af130448ba958b8c077df401f9
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4
The secreted metabolome of HeLa cells under effect of Crotamine, a cell-penetrating peptide from a rattlesnake using NMR-based metabolomics analyses
Autor: Monika Aparecida Coronado, Fábio Rogério de Moraes, Bruna Stuqui, Marília Freitas Calmon, Raphael Josef Eberle, Paula Rahal, Raghuvir Krishnaswamy Arni
Publikováno v: BioMed 2(2), 238-254 (2022). doi:10.3390/biomed2020020
BioMed; Volume 2; Issue 2; Pages: 238-254
Sequestering and reprogramming of cellular metabolism represents one of the principal hallmarks of several cells. Antimicrobial peptides have been shown to exhibit selective anticancer activities. In this study, the secreted metabolome of HeLa cells
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fc8bba9870abaa3e3057d0332c319c8
https://doi.org/10.1101/2022.01.15.476435
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5
Design of D-Amino Acids SARS-CoV-2 Main Protease Inhibitors Using the Cationic Peptide from Rattlesnake Venom as a Scaffold
Autor: Marcos Serrou do Amaral, Monika A. Coronado, Raghuvir K. Arni, Philipp Niklas Ostermann, Danilo S. Olivier, Raphael Josef Eberle, Lisa Mueller, Ian Gering, Markus Tusche, Dieter Willbold, Heiner Schaal, Ortwin Adams
Publikováno v: Pharmaceuticals 15(5), 540-(2022). doi:10.3390/ph15050540
Pharmaceuticals; Volume 15; Issue 5; Pages: 540
The C30 Endopeptidase (3C-like protease; 3CLpro) is essential for the life cycle of SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2) since it plays a pivotal role in viral replication and transcription and is hence a promising drug target
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38685e982617243293bba9dc4ecd9f0b
https://hdl.handle.net/2128/31631
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6
Promising natural compounds against flavivirus proteases: Citrus flavonoids hesperetin and hesperidin
Autor: Marcos Serrou do Amaral, Monika A. Coronado, Dieter Willbold, Raghuvir K. Arni, Raphael Josef Eberle, Danilo S. Olivier
Publikováno v: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Plants, Vol 10, Iss 2183, p 2183 (2021)
Plants
Volume 10
Issue 10
Plants 10(10), 2183-(2021). doi:10.3390/plants10102183
Ubiquitous in citrus plants, Hesperidin and Hesperetin flavanones possess several biological functions, including antiviral activity. Arbovirus infections pose an ever-increasing threat to global healthcare systems. Among the severe arboviral infecti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00cc5474a297811d94441cef26cb8144
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8
Review of -omics studies on mosquito-borne viruses of the Flavivirus genus
Autor: Raphael Josef Eberle, Rafaela dos S. Peinado, Carolina Colombelli Pacca, Monika A. Coronado, Raghuvir K. Arni
Publikováno v: Virus Research. 307:198610
Arboviruses are transmitted by arthropods (arthropod-borne virus) which can be mosquitoes or other hematophagous arthropods, in which their life cycle occurs before transmission to other hosts. Arboviruses such as Dengue, Zika, Saint Louis Encephalit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c66d144d215237db12700023569cf2b
https://doi.org/10.1016/j.virusres.2021.198610
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9
Modeling and molecular dynamics indicate that snake venom phospholipase B-like enzymes are Ntn-hydrolases
Autor: Marcos Serrou do Amaral, Raghuvir K. Arni, Raphael Josef Eberle, Monika A. Coronado, Danilo S. Olivier
Publikováno v: Toxicon. 153:106-113
Phospholipase-B-like (SVPLB-like) enzymes are present in relatively small amounts in a number of venoms, however, their biological function and mechanisms of action are un-clear. A three-dimensional model of the SVPLB-like enzyme from Crotalus adaman
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55bac22a1a08c025a1fbd1695ba1bc15
https://doi.org/10.1016/j.toxicon.2018.08.014
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