Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Raphael Jean Courjaret"'
Autor:
Aparna Gudlur, Robert M. Nwokonko, Ryan E. Yoast, Mohamed Trebak, Nadine Hempel, Donald L. Gill, Martin Johnson, Scott M. Emrich, Ping Xin, Xuexin Zhang, Patrick G. Hogan, Raphael Jean Courjaret, Khaled Machaca, Wei Li
Publikováno v:
Proceedings of the National Academy of Sciences. 117:17369-17380
Voltage-gated L-type Ca2+ channel (Cav1.2) blockers (LCCBs) are major drugs for treating hypertension, the preeminent risk factor for heart failure. Vascular smooth muscle cell (VSMC) remodeling is a pathological hallmark of chronic hypertension. VSM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c41bb9e7240902f70e858f7fce582cb
https://doi.org/10.1073/pnas.2007598117
https://doi.org/10.1073/pnas.2007598117
Autor:
Hassan S. Bazzi, Mohammed Al-Hashimi, Khaled Machaca, Raphael Jean Courjaret, Upendar Reddy Gandra
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
There a few reports of rhodamine-based fluorescent sensors for selective detection of only Al3+, due to the challenge of identifying a suitable ligand for binding Al3+ ion. The use of fluorophore moieties appended to a polymer backbone for sensing ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b499230f90d3c83d434f6761083d0d75
http://europepmc.org/articles/PMC7658199
http://europepmc.org/articles/PMC7658199
Autor:
Khaled Machaca, Raphael Jean Courjaret
Publikováno v:
Cell Calcium. 97:102421
Our current understanding of the molecular mechanisms underlying activation of store-operated Ca2+ entry (SOCE) relies in large part on studies that modulate the expression of STIM1 and Orai1. Shen et al. present the first detailed study to address t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614f6d73ce1b57b4a60eb0f41355a4c6
https://doi.org/10.1016/j.ceca.2021.102421
https://doi.org/10.1016/j.ceca.2021.102421
Autor:
Raja Dey, Asha Elmi, Ayat S. Hammad, Raphael Jean Courjaret, Khaled Machaca, Nancy Nader, Maya Dib, Rawad Hodeify, Xin-Yun Huang
Publikováno v:
PLoS Biology, Vol 19, Iss 2, p e3001117 (2021)
The steroid hormone progesterone (P4) mediates many physiological processes through either nuclear receptors that modulate gene expression or membrane P4 receptors (mPRs) that mediate nongenomic signaling. mPR signaling remains poorly understood. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3863f975dd4b859dbd6dbe58bd9ef831
https://doi.org/10.1371/journal.pbio.3001117
https://doi.org/10.1371/journal.pbio.3001117
Publikováno v:
Journal of Cellular Physiology. 232:1095-1103
Ca2+ signaling is ubiquitous and mediates various cellular functions encoded in its spatial, temporal, and amplitude features. Here, we investigate the role of store-operated Ca2+ entry (SOCE) in regulating the temporal dynamics of Ca2+ signals in Xe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd498c774c12aec9436e540fb2c9d1e5
https://doi.org/10.1002/jcp.25513
https://doi.org/10.1002/jcp.25513
Autor:
Hannah M. Jahn, Raphael Jean Courjaret, Nanette Messemer, Joachim W. Deitmer, Ramona Rudolph, Frank Kirchhoff
Publikováno v:
Glia. 64:1265-1280
Synaptic transmission has been shown to be modulated by glial functions, but the modes of specific glial action may vary in different neural circuits. We have tested the hypothesis, if Bergmann GLIA (BG) are involved in shaping neuronal communication
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1d16a0dc53e888bf2c87774d8201c3e
https://doi.org/10.1002/glia.22999
https://doi.org/10.1002/glia.22999
Autor:
Raphael Jean Courjaret, Maryam Own, Satanay Hubrack, Johannes Graumann, Khaled Machaca, Rawad Hodeify, Manjula Nandakumar
Publikováno v:
Science Advances. 4
Store-operated Ca 2+ entry (SOCE) encodes a range of cellular responses downstream of Ca 2+ influx through the SOCE channel Orai1. Orai1 recycles at the plasma membrane (PM), with ~40% of the total Orai1 pool residing at the PM at steady state. The m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4214d747e5d0342f32aa8325538c6bf4
https://doi.org/10.1126/sciadv.aau1935
https://doi.org/10.1126/sciadv.aau1935
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports
Scientific Reports
Agonist-dependent Ca2+ mobilization results in Ca2+ store depletion and Store-Operated Calcium Entry (SOCE), which is spatially restricted to microdomains defined by cortical ER – plasma membrane contact sites (MCS). However, some Ca2+-dependent ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98adc9c61a73fdeb74fc865f2a5e486d
https://doi.org/10.1038/s41598-018-29562-9
https://doi.org/10.1038/s41598-018-29562-9
Autor:
Khaled Machaca, Nancy Nader, Raphael Jean Courjaret, Rawad Hodeify, Johannes Graumann, Maya Dib, Raya Machaca
Publikováno v:
Journal of Cell Science.
Progesterone mediates its physiological functions through activation of both transcription-coupled nuclear receptors and seven-pass-transmembrane progesterone receptors (mPRs), which transduce the rapid non-genomic actions of progesterone by coupling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c4a123ebb6924ac20c33c22cbf8f1e
https://doi.org/10.1242/jcs.212522
https://doi.org/10.1242/jcs.212522
Publikováno v:
Qatar Foundation Annual Research Conference Proceedings Volume 2018 Issue 2.
Background - The regenerative ability of the heart is very low, making patients with myocardial damage potential candidates for cell-based regenerative therapy. Pluripotent human embryonic stem cells (hESC) are a promising source of repopulating card
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2294de5b8152aa2f0e3afd18bf238085
https://doi.org/10.5339/qfarc.2018.hbpp746
https://doi.org/10.5339/qfarc.2018.hbpp746