Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Raphael J. Mannino"'
Autor:
Teclegiorgis Gebremariam, Yiyou Gu, Sondus Alkhazraji, Eman Youssef, Theresa Matkovits, Jenel Cobb, Raphael J Mannino, Ashraf S Ibrahim
Publikováno v:
Open Forum Infectious Diseases. 9
Background Invasive mucormycosis (IM) is associated with high mortality and morbidity. MAT2203 is an encochleated oral formulation of amphotericin B which has been shown to be safe and effective against murine aspergillosis and murine cryptococcal me
Autor:
Mucunguzi Atukunda, David R. Boulware, Darlisha A. Williams, Eva Laker, David B. Meya, Joshua Rhein, Nicole Engen, Katherine Huppler Hullsiek, Anna M Stadelman, Theresa Matkovits, Caleb P Skipper, Raphael J. Mannino, Mahsa Abassi, Ananta S Bangdiwala, Melanie R. Nicol
Publikováno v:
Antimicrobial agents and chemotherapy. 64(10)
Amphotericin B deoxycholate (AMB) has substantial toxicities. A novel encochleated amphotericin B deoxycholate (cAMB) formulation has oral bioavailability, efficacy in an animal model, and minimal toxicity due to targeted drug delivery into macrophag
Autor:
Theresa Matkovits, Amanda Urban, Alexandra F. Freeman, Elise M. N. Ferré, Raphael J. Mannino, Michail S. Lionakis, Edmund C. Tramont, Benjamin Colton, Doris Z Swaim, Ruying Lu, Jigar V. Desai
Publikováno v:
Open Forum Infectious Diseases
Background Candida albicans causes debilitating mucosal infections in patients with inherited susceptibility to chronic mucocutaneous candidiasis (CMC), often requiring long-term azole-based treatment. Due to increasing azole resistance, alternative
Publikováno v:
Open Forum Infectious Diseases
Background In the cystic fibrosis lung, infections by intracellular pathogens, such as Mycobacteria, are problematic to treat due to a thick buildup of mucous as well as the difficulty of many anti-microbial agents, such as amikacin, to penetrate acr
Autor:
Benjamin Colton, Alexandra F. Freeman, Michail S. Lionakis, Ruying Lu, Amanda Urban, Lilian W. Kibathi, Raphael J. Mannino, Edmund C. Tramont, Chris Lambros, Elise M. N. Ferré, Maryellen McManus, Parag Kumar
Publikováno v:
Open Forum Infectious Diseases
Background Current oral therapeutic options for chronic mucocutaneous candidiasis (CMC) are often associated with resistance and toxicity. Amphotericin B (AMB) has broad fungicidal activity and markedly resists emergence of resistance but requires pa
Autor:
Ruying Lu, Jerry Jabbour, Michail S. Lionakis, Alexandra F. Freeman, Jigar V. Desai, Edmund C. Tramont, Raphael J. Mannino
Publikováno v:
Open Forum Infectious Diseases
Background Candida albicans causes debilitating mucosal infections in patients with inherited susceptibility to chronic mucocutaneous candidiasis (CMC) such as oropharyngeal candidiasis (OPC) and vulvovaginal candidiasis (VVC), which often require lo
Autor:
Ruying Lu, Raphael J. Mannino
Publikováno v:
Open Forum Infectious Diseases. 3
Autor:
Ruying Lu, Susan Bonitz, Paolo Carminati, Valeria D'Alessio, Diletta Di Mitri, Brunilde Arseni, Patrick Ahl, Luca Battistini, Rita De Santis, Stefania Rossi, Joel Ngoje, Silvia Campo, Vito Ruggiero, Raphael J. Mannino
Publikováno v:
Transplantation. 86:171-175
We have previously demonstrated that the compound 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole exerts immunosuppressive effects in several experimental models of autoimmunity. These results were achieved by subcutaneously administering ST1
Autor:
Pankaj B. Desai, Larry Sallans, Chris Lambros, Keeley Lynch, Alan Ashbaugh, Margaret S. Collins, Michael J. Linke, Melanie T. Cushion, J. Carl Craft, Edmund C. Tramont, Raphael J. Mannino, Ruying Lu, Joseph A. Kovacs, Parag Kumar, Thomas Sesterhenn, Ganesh Moorthy, Susan Bonitz
Publikováno v:
Open Forum Infectious Diseases. 2
Antifungal Activity of Amphotericin B Cochleates against Candida albicans Infection in a Mouse Model
Autor:
Laura K. Najvar, John R. Graybill, Leila Zarif, Rosie Bocanegra, David S. Perlin, Raphael J. Mannino
Publikováno v:
Antimicrobial Agents and Chemotherapy. 44:1463-1469
Cochleates are lipid-based supramolecular assemblies composed of natural products, negatively charged phospholipid, and a divalent cation. Cochleates can encapsulate amphotericin B (AmB), an important antifungal drug. AmB cochleates (CAMB) have a uni