Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Raphael J. Crum"'
Autor:
Raphael J. Crum, Kelsey Hall, Catalina Pineda Molina, George S. Hussey, Emma Graham, Hongshuai Li, Stephen F. Badylak
Publikováno v:
npj Regenerative Medicine, Vol 7, Iss 1, Pp 1-12 (2022)
Abstract Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and destruction of synovial joints affecting ~7.5 million people worldwide. Disease pathology is driven by an imbalance in the ratio of pro-inflammatory
Externí odkaz:
https://doaj.org/article/88c4d35caf9649359bedd408866baf8c
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-18 (2020)
Abstract Background Cope’s gray treefrog, Dryophytes chrysoscelis, withstands the physiological challenges of corporeal freezing, partly by accumulating cryoprotective compounds of hepatic origin, including glycerol, urea, and glucose. We hypothesi
Externí odkaz:
https://doaj.org/article/8b6b9e278b634614b9663d7db63d90be
Publikováno v:
Applied Sciences, Vol 12, Iss 15, p 7472 (2022)
Tissue engineering and regenerative medicine (TERM) may be defined as a translational discipline focused on the development of novel techniques, devices, and materials to replace or repair injured or diseased tissue and organs. The main approaches ty
Externí odkaz:
https://doaj.org/article/0581396863d9408585f2ad24cfcb0735
Autor:
Raphael J. Crum, Héctor Capella-Monsonís, Jordan Chang, Marley J. Dewey, Brian D. Kolich, Kelsey T. Hall, Salma O. El-Mossier, David G. Nascari, George S. Hussey, Stephen F. Badylak
Publikováno v:
Acta Biomaterialia. 155:113-122
Matrix-bound nanovesicles (MBV) are a distinct subtype of extracellular vesicles that are firmly embedded within biomaterials composed of extracellular matrix (ECM). MBV both store and transport a diverse, tissue specific portfolio of signaling molec
Autor:
Raphael J. Crum, Scott A. Johnson, Peng Jiang, Jayati H. Jui, Ruben Zamora, Devin Cortes, Mangesh Kulkarni, Archana Prabahar, Jennifer Bolin, Eric Gann, Eric Elster, Seth A. Schobel, Dale Larie, Chase Cockrell, Gary An, Bryan Brown, Milos Hauskrecht, Yoram Vodovotz, Stephen F. Badylak
Publikováno v:
Tissue Engineering Part A. 28:941-957
Skeletal muscle has a robust, inherent ability to regenerate in response to injury from acute to chronic. In severe trauma, however, complete regeneration is not possible, resulting in a permanent loss of skeletal muscle tissue referred to as volumet
Autor:
Raphael J. Crum, Brydie R. Huckestien, Gaelen Dwyer, Lisa Mathews, David G. Nascari, George S. Hussey, Heth R. Turnquist, John F. Alcorn, Stephen F. Badylak
Publikováno v:
Science Advances. 9
Cytokine storm describes a life-threatening, systemic inflammatory syndrome characterized by elevated levels of proinflammatory cytokines and immune cell hyperactivation associated with multi-organ dysfunction. Matrix-bound nanovesicles (MBV) are a s
Autor:
Anne Behre, Joshua W. Tashman, Caner Dikyol, Daniel J. Shiwarski, Raphael J. Crum, Scott A. Johnson, Remya Kommeri, George S. Hussey, Stephen F. Badylak, Adam W. Feinberg
Publikováno v:
Advanced healthcare materials. 11(24)
Soft tissue injuries such as volumetric muscle loss (VML) are often too large to heal normally on their own, resulting in scar formation and functional deficits. Decellularized extracellular matrix (dECM) scaffolds placed into these wounds have shown
Autor:
Yoojin C. Lee, Brian Kolich, George S. Hussey, William D'Angelo, Jenna L. Dziki, Lindsey T. Saldin, David Nascari, Salma O. El-Mossier, Raphael J. Crum, Stephen F. Badylak
Publikováno v:
Acta Biomaterialia. 108:77-86
Hydrogels composed of extracellular matrix (ECM) have been used as a substrate for 3D organoid culture, and in numerous preclinical and clinical applications to facilitate repair and reconstruction of a variety of tissues. However, these ECM hydrogel
Autor:
Eric J. Kropf, Alan Getgood, Michael G. Baraga, Asheesh Bedi, Craig S. Mauro, Dharmesh Vyas, Bryson P. Lesniak, Volker Musahl, Olufemi R. Ayeni, Stephen J. Rabuck, Scott G. Kaar, Devin Peterson, Raphael J. Crum, Darren de Sa
Publikováno v:
J Knee Surg
Revision anterior cruciate ligament (ACL) procedures are increasing in incidence and possess markedly inferior clinical outcomes (76% satisfaction) and return-to-sports (57%) rates than their primary counterparts. Given their complexity, a universal
Autor:
Raphael J, Crum, Kelsey, Hall, Catalina Pineda, Molina, George S, Hussey, Emma, Graham, Hongshuai, Li, Stephen F, Badylak
Publikováno v:
NPJ Regenerative medicine. 7(1)
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and destruction of synovial joints affecting ~7.5 million people worldwide. Disease pathology is driven by an imbalance in the ratio of pro-inflammatory vs. anti