Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype

Autor: Raphael Hesse, Maica Llavero Hurtado, Rosemary J. Jackson, Samantha L. Eaton, Abigail G. Herrmann, Marti Colom-Cadena, Makis Tzioras, Declan King, Jamie Rose, Jane Tulloch, Chris-Anne McKenzie, Colin Smith, Christopher M. Henstridge, Douglas Lamont, Thomas M. Wishart, Tara L. Spires-Jones

Publikováno v: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-18 (2019)

Abstract Degeneration of synapses in Alzheimer’s disease (AD) strongly correlates with cognitive decline, and synaptic pathology contributes to disease pathophysiology. We recently observed that the strongest genetic risk factor for sporadic AD, ap

Externí odkaz: https://doaj.org/article/ad825fe296684195b97f38283374885a

Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype

Autor: Christopher M. Henstridge, Raphael Hesse, Douglas J. Lamont, Martí Colom-Cadena, Jane Tulloch, Jamie Rose, Samantha L. Eaton, Tara L. Spires-Jones, Chris-Anne McKenzie, Abigail G. Herrmann, Thomas M. Wishart, Makis Tzioras, Declan King, Colin Smith, Rosemary J. Jackson, Maica Llavero Hurtado

Publikováno v: Acta Neuropathologica Communications
Hesse, R, Llavero Hurtado, M, Jackson, R J, Eaton, S L, Herrmann, A G, Colom-Cadena, M, Tzioras, M, King, D, Rose, J, Tulloch, J, McKenzie, C-A, Smith, C, Henstridge, C M, Lamont, D, Wishart, T M & Spires-Jones, T L 2019, ' Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype ', Acta Neuropathologica Communications, vol. 7, 214 . https://doi.org/10.1186/s40478-019-0847-7
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-18 (2019)

Degeneration of synapses in Alzheimer’s disease (AD) strongly correlates with cognitive decline, and synaptic pathology contributes to disease pathophysiology. We recently discovered that the strongest genetic risk factor for sporadic AD, apolipopr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbdab1fd40528fdce679bbb7558ea9f4
https://doi.org/10.1186/s40478-019-0847-7

sAPPβ and sAPPα increase structural complexity and E/I input ratio in primary hippocampal neurons and alter Ca

Autor: Raphael, Hesse, Bjoern, von Einem, Franziska, Wagner, Patricia, Bott, Daniel, Schwanzar, Rosemary J, Jackson, Karl Josef, Föhr, Ludwig, Lausser, Katja S, Kroker, Christian, Proepper, Paul, Walther, Hans A, Kestler, Tara L, Spires-Jones, Tobias, Boeckers, Holger, Rosenbrock, Christine A F, von Arnim

Publikováno v: Experimental neurology. 304

One major pathophysiological hallmark of Alzheimer's disease (AD) is senile plaques composed of amyloid β (Aβ). In the amyloidogenic pathway, cleavage of the amyloid precursor protein (APP) is shifted towards Aβ production and soluble APPβ (sAPP�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::343cb254e1375635f29c4839f4f337ca
https://pubmed.ncbi.nlm.nih.gov/29466703

Reduced cGMP levels in CSF of AD patients correlate with severity of dementia and current depression

Autor: Anke Wahler, Pauline Gummert, Christine A. F. von Arnim, Florian Schmid, Raphael Hesse, Hayrettin Tumani, Katja S. Kroker, Markus Otto, Holger Rosenbrock, Ludwig Lausser, Hans A. Kestler, Cathrin Schnack

Publikováno v: Alzheimer's Research & Therapy

Background Alzheimer’s disease (AD) is a neurodegenerative disorder, primarily affecting memory. That disorder is thought to be a consequence of neuronal network disturbances and synapse loss. Decline in cognitive function is associated with a high

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cde1cac793e6d60df17a4d6f291927d