Zobrazeno 1 - 10
of 276
pro vyhledávání: '"Raphael Gottardo"'
Autor:
Mathilde Foglierini, Pauline Nortier, Rachel Schelling, Rahel R. Winiger, Philippe Jacquet, Sijy O’Dell, Davide Demurtas, Maxmillian Mpina, Omar Lweno, Yannick D. Muller, Constantinos Petrovas, Claudia Daubenberger, Matthieu Perreau, Nicole A. Doria-Rose, Raphael Gottardo, Laurent Perez
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Broadly neutralizing antibodies (bNAbs) are promising candidates for the treatment and prevention of HIV-1 infections. Despite their critical importance, automatic detection of HIV-1 bNAbs from immune repertoires is still lacking. Here, we d
Externí odkaz:
https://doaj.org/article/9d102f79207c417eb04c2d3080c48cb2
Autor:
Anissa Fries, Fanny Saidoune, François Kuonen, Isabelle Dupanloup, Nadine Fournier, Ana Cristina Guerra de Souza, Muzlifah Haniffa, Feiyang Ma, Johann E. Gudjonsson, Lennart Roesner, Yang Li, Thomas Werfel, Curdin Conrad, Raphael Gottardo, Robert L. Modlin, Jeremy Di Domizio, Michel Gilliet
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Interleukin (IL)-26 is a TH17 cytokine with known antimicrobial and pro-inflammatory functions. However, the precise role of IL-26 in the context of pathogenic TH17 responses is unknown. Here we identify a population of blood TH17 intermedia
Externí odkaz:
https://doaj.org/article/9a6badc4e12148d591a4960524014626
Autor:
Jung Hyun Lee, Justin Daho Lee, Kelly Paulson, Valentin Voillet, Andre Berndt, Candice Church, Kristina Lachance, Song Y. Park, Naomi K. Yamamoto, Elizabeth A. Cromwell, Raphael Gottardo, Aude G. Chapuis, Paul Nghiem
Publikováno v:
Heliyon, Vol 10, Iss 1, Pp e23521- (2024)
Approximately 50% of Merkel cell carcinoma (MCC) patients facing this highly aggressive skin cancer initially respond positively to PD-1-based immunotherapy. Nevertheless, the recurrence of MCC post-immunotherapy emphasizes the pressing need for more
Externí odkaz:
https://doaj.org/article/6b3e03a0dc0c42df8e077d2b0c8553fb
Autor:
Philip D Greenberg, Valentin Voillet, Raphael Gottardo, Kristin G Anderson, Breanna M Bates, Madison G Burnett, Susan L Ruskin, Yapeng Su, Magdalia L Suarez Gutierrez
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/02aa15847e644c8caf9301b40b6a786b
Autor:
Joann Diray-Arce, Helen E. R. Miller, Evan Henrich, Bram Gerritsen, Matthew P. Mulè, Slim Fourati, Jeremy Gygi, Thomas Hagan, Lewis Tomalin, Dmitry Rychkov, Dmitri Kazmin, Daniel G. Chawla, Hailong Meng, Patrick Dunn, John Campbell, The Human Immunology Project Consortium (HIPC), Minnie Sarwal, John S. Tsang, Ofer Levy, Bali Pulendran, Rafick Sekaly, Aris Floratos, Raphael Gottardo, Steven H. Kleinstein, Mayte Suárez-Fariñas
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-16 (2022)
Measurement(s) Transcriptomics • Hemagglutination Inhibition Assay • IgG IgM IgA Total Measurement • Virus-neutralizing Antibody • ELISA Technology Type(s) Microarray • RNA sequencing • Hemagglutination Inhibition Assay • ELISA • Micr
Externí odkaz:
https://doaj.org/article/e29b684ada444c44833f7762240235b8
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-17 (2022)
Abstract We consider an increasingly popular study design where single-cell RNA-seq data are collected from multiple individuals and the question of interest is to find genes that are differentially expressed between two groups of individuals. Toward
Externí odkaz:
https://doaj.org/article/a73b1c8eec8a4739ad8b8d5179fa1e70
Autor:
Alexandre A Germanos, Sonali Arora, Ye Zheng, Erica T Goddard, Ilsa M Coleman, Anson T Ku, Scott Wilkinson, Hanbing Song, Nicholas J Brady, Robert A Amezquita, Michael Zager, Annalysa Long, Yu Chi Yang, Jason H Bielas, Raphael Gottardo, David S Rickman, Franklin W Huang, Cyrus M Ghajar, Peter S Nelson, Adam G Sowalsky, Manu Setty, Andrew C Hsieh
Publikováno v:
eLife, Vol 11 (2022)
Advanced prostate malignancies are a leading cause of cancer-related deaths in men, in large part due to our incomplete understanding of cellular drivers of disease progression. We investigate prostate cancer cell dynamics at single-cell resolution f
Externí odkaz:
https://doaj.org/article/df92bed0fdd1409a988b59a78b4ffbca
Autor:
Vladimir Makarov, Paul Nghiem, Jaehyuk Choi, Timothy A Chan, Kimberly S Smythe, Jean S Campbell, Robert H Pierce, Raphael Gottardo, Candice Church, David M Koelle, Thomas Pulliam, Natalie Longino, Song Y Park, Nadeem Riaz, Lichen Jing, Robert Amezquita
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)
Background Merkel cell carcinoma (MCC) often responds to PD-1 pathway blockade, regardless of tumor-viral status (~80% of cases driven by the Merkel cell polyomavirus (MCPyV)). Prior studies have characterized tumor-specific T cell responses to MCPyV
Externí odkaz:
https://doaj.org/article/5ad5aa1d8a2c41f09cc92ec9ecc890fa
Autor:
Alessandra Noto, Madeleine Suffiotti, Victor Joo, Antonio Mancarella, Francesco A. Procopio, Guy Cavet, Yvonne Leung, Jean-Marc Corpataux, Matthias Cavassini, Agostino Riva, Leonidas Stamatatos, Raphael Gottardo, Adrian B. McDermott, Richard A. Koup, Craig Fenwick, Matthieu Perreau, Giuseppe Pantaleo
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Optimal T follicular helper (Tfh) cells function is important to promote the development of germinal centers and maturation of high affinity antigen-specific B cells. We have found that the expression of CXCR3 defines distinct Tfh subsets: CXCR3+ Th1
Externí odkaz:
https://doaj.org/article/f7bc6d2291a744dca296140e03ea8ac7
Autor:
Beatriz Perdiguero, Benedikt Asbach, Carmen E. Gómez, Josef Köstler, Susan W. Barnett, Marguerite Koutsoukos, Deborah E. Weiss, Anthony D. Cristillo, Kathryn E. Foulds, Mario Roederer, David C. Montefiori, Nicole L. Yates, Guido Ferrari, Xiaoying Shen, Sheetal Sawant, Georgia D. Tomaras, Alicia Sato, William J. Fulp, Raphael Gottardo, Song Ding, Jonathan L. Heeney, Giuseppe Pantaleo, Mariano Esteban, Ralf Wagner
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
To control HIV infection there is a need for vaccines to induce broad, potent and long-term B and T cell immune responses. With the objective to accelerate and maintain the induction of substantial levels of HIV-1 Env-specific antibodies and, at the
Externí odkaz:
https://doaj.org/article/6036c61a4c684d169531306cb6b2b597