Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Raphael Geney"'
Autor:
R Galien, Raphael Geney, Koen Kurt Smits, Béatrice Vayssière, Thierry Christophe, Reginald Brys, L. Lepescheux, Ellen van der Aar, Luc Nelles, Fabrice Ciesielski, Guy Van Lommen, Pierre Deprez, Luc Juliaan Corina Van Rompaey, Muriel Uhring, Stephen Robert Fletcher, Christel Jeanne Marie Menet, Philippe Clément-Lacroix, Javier Blanc, Nolwenn Jouannigot
Publikováno v:
Journal of Medicinal Chemistry. 57:9323-9342
Janus kinases (JAK1, JAK2, JAK3, and TYK2) are involved in the signaling of multiple cytokines important in cellular function. Blockade of the JAK-STAT pathway with a small molecule has been shown to provide therapeutic immunomodulation. Having ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9517bf576a1a79fdee93942c785e39bf
https://doi.org/10.1021/jm501262q
https://doi.org/10.1021/jm501262q
In this review, we describe the current knowledge of the biology of the JAKs. The JAK family comprises the four nonreceptor tyrosine kinases JAK1, JAK2, JAK3, and Tyk2, all key players in the signal transduction from cytokine receptors to transcripti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7d4880621f209be38e1f60b75140d36
https://doi.org/10.1016/b978-0-444-62652-3.00004-1
https://doi.org/10.1016/b978-0-444-62652-3.00004-1
Publikováno v:
Anti-cancer agents in medicinal chemistry. 13(5)
With the advent of the Type II kinase inhibitor imatinib (Gleevec) for treatment against cancer, rational design of tailored molecules has brought a revolution in medicinal chemistry for treating tumours caused by kinase malfunctioning. Among differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::207bd7c526cda6978defcab19a35bcdf
https://pubmed.ncbi.nlm.nih.gov/23094911
https://pubmed.ncbi.nlm.nih.gov/23094911
Autor:
Liang Sun, Xudong Geng, Raphael Geney, Yuan Li, Simmerling, Carlos, Zhong Li, Joseph W. Lauher, Shujun Xia, Horwitz, Susan B., Veith, Jean M., Pera, Paula, Bernacki, Ralph J., Ojima, Iwao
Publikováno v:
Journal of Organic Chemistry; 12/19/2008, Vol. 73 Issue 24, p9584-9593, 10p, 1 Chart, 9 Graphs
Publikováno v:
Chemical & Engineering News. 7/26/2004, Vol. 82 Issue 30, p48-49. 2p.
Autor:
Witty, D. R., Lawton, G.
Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required of the modern medicinal chemist; in particular, the us