The Succinate Receptor SUCNR1 Resides at the Endoplasmic Reticulum and Relocates to the Plasma Membrane in Hypoxic Conditions

Autor: Melanie Sanchez, David Hamel, Emmanuel Bajon, François Duhamel, Vikrant K. Bhosle, Tang Zhu, Jose Carlos Rivera, Rabah Dabouz, Mathieu Nadeau-Vallée, Nicholas Sitaras, David-Étienne Tremblay, Samy Omri, Tiffany Habelrih, Raphael Rouget, Xin Hou, Fernand Gobeil, Jean-Sébastien Joyal, Przemyslaw Sapieha, Grant Mitchell, Alfredo Ribeiro-Da-Silva, Mohammad Ali Mohammad Nezhady, Sylvain Chemtob

Publikováno v: Cells, Vol 11, Iss 14, p 2185 (2022)

The GPCR SUCNR1/GPR91 exerts proangiogenesis upon stimulation with the Krebs cycle metabolite succinate. GPCR signaling depends on the surrounding environment and intracellular localization through location bias. Here, we show by microscopy and by ce

Externí odkaz: https://doaj.org/article/08718907106b4199a8f209beb94c4878

Implication of repeat insertion domains in the trans -activity of the long non-coding RNA ANRIL

Autor: Virginie Marchand, Isabelle Behm-Ansmant, Aymeric Sanchez, Christiane Branlant, Charbel Alfeghaly, Yuri Motorin, Valérie Igel-Bourguignon, Sylvain Maenner, Raphael Rouget, Quentin Thuillier

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2021, 49 (9), pp.4954-4970. ⟨10.1093/nar/gkab245⟩
Nucleic Acids Research, 2021, 49 (9), pp.4954-4970. ⟨10.1093/nar/gkab245⟩

Long non-coding RNAs have emerged as critical regulators of cell homeostasis by modulating gene expression at chromatin level for instance. Here, we report that the lncRNA ANRIL, associated with several pathologies, binds to thousands of loci dispers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98a1e1dad7415a4c3d02f7eb6f16c66
https://hal.univ-lorraine.fr/hal-03202552

PI 3 kinase related kinases-independent proteolysis of BRCA1 regulates Rad51 recruitment during genotoxic stress in human cells.

Autor: Ian Hammond-Martel, Helen Pak, Helen Yu, Raphael Rouget, Andrew A Horwitz, Jeffrey D Parvin, Elliot A Drobetsky, El Bachir Affar

Publikováno v: PLoS ONE, Vol 5, Iss 11, p e14027 (2010)

The function of BRCA1 in response to ionizing radiation, which directly generates DNA double strand breaks, has been extensively characterized. However previous investigations have produced conflicting data on mutagens that initially induce other cla

Externí odkaz: https://doaj.org/article/71ebaf2397b44b62b44bdde2c71e36cc

Overexpression of PP1-NIPP1 limits the repair capacity of DNA double-strand breaks

Autor: Claudia Winkler, Dan Wu, Aleyde Van Eynde, Raphael Rouget, Mathieu Bollen, Monique Beullens

Publikováno v: Journal of Cell Science.

The ubiquitously expressed nuclear protein NIPP1 (also known as PPP1R8) recruits phosphoproteins for regulated dephosphorylation by the associated protein phosphatase PP1. To bypass the PP1 titration artifacts seen upon NIPP1 overexpression, we have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6468be28df77db38b0f146404ef99b9f
https://doi.org/10.1242/jcs.214932

Erratum: Nuclear localization of platelet-activating factor receptor controls retinal neovascularization

Autor: Vikrant K Bhosle, José Carlos Rivera, Tianwei Zhou, Samy Omri, Melanie Sanchez, David Hamel, Tang Zhu, Raphael Rouget, Areej Al Rabea, Xin Hou, Isabelle Lahaie, Alfredo Ribeiro-da-Silva, Sylvain Chemtob

Publikováno v: Cell Discovery. 2

Correction to: Cell Discovery (2016) 2, 16017; doi:10.1038/celldisc.2016.17; published online 12 July 2016 In the initial publication of this article, the abbreviation of the first author’s name in citation ‘K Bhosle V’ was incorrect, which sho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4c5224031bdc47b228c3abad2fa26db
https://doi.org/10.1038/celldisc.2016.34