Výsledky vyhledávání - "Raphael, Reher"

Akademický článek

DeepSAT: Learning Molecular Structures from Nuclear Magnetic Resonance Data

Autor: Hyun Woo Kim, Chen Zhang, Raphael Reher, Mingxun Wang, Kelsey L. Alexander, Louis-Félix Nothias, Yoo Kyong Han, Hyeji Shin, Ki Yong Lee, Kyu Hyeong Lee, Myeong Ji Kim, Pieter C. Dorrestein, William H. Gerwick, Garrison W. Cottrell

Publikováno v: Journal of Cheminformatics, Vol 15, Iss 1, Pp 1-12 (2023)

Abstract The identification of molecular structure is essential for understanding chemical diversity and for developing drug leads from small molecules. Nevertheless, the structure elucidation of small molecules by Nuclear Magnetic Resonance (NMR) ex

Externí odkaz: https://doaj.org/article/ea05f56befd0470b8ac790f9bec2bb4f

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Akademický článek

Native metabolomics identifies the rivulariapeptolide family of protease inhibitors

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)

Bioactivity-guided isolation of specialized metabolites is an iterative process. Here, the authors demonstrate a native metabolomics approach that allows for fast screening of complex metabolite extracts against a protein of interest and simultaneous

Externí odkaz: https://doaj.org/article/b4de9418b20d4c4ebe6ea5392f4b3a2b

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Akademický článek

Lack of beta-arrestin signaling in the absence of active G proteins

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)

Arrestins terminate signaling from GPCRs, but several lines of evidence suggest that they are also able to transduce signals independently of G proteins. Here, the authors systematically ablate G proteins in cell lines, and show that arrestins are un

Externí odkaz: https://doaj.org/article/e038d4ec42a84fe0b5f232ccf68a180d

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Akademický článek

A Multi-Omics Characterization of the Natural Product Potential of Tropical Filamentous Marine Cyanobacteria

Publikováno v: Marine Drugs, Vol 19, Iss 1, p 20 (2021)

Microbial natural products are important for the understanding of microbial interactions, chemical defense and communication, and have also served as an inspirational source for numerous pharmaceutical drugs. Tropical marine cyanobacteria have been h

Externí odkaz: https://doaj.org/article/101512516a0548af860ab9e550043794

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NPClassifier: A Deep Neural Network-Based Structural Classification Tool for Natural Products

Autor: Pieter C. Dorrestein, Garrison W. Cottrell, Louis-Félix Nothias, Justin J. J. van der Hooft, Christopher A. Leber, Kyo Bin Kang, William H. Gerwick, Raphael Reher, Hyun-Woo Kim, Mingxun Wang

Publikováno v: Journal of natural products, vol 84, iss 11
Journal of Natural Products, 84(11), 2795-2807
Journal of Natural Products 84 (2021) 11

Computational approaches such as genome and metabolome mining are becoming essential to natural products (NPs) research. Consequently, a need exists for an automated structure-type classification system to handle the massive amounts of data appearing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f6aeee0713e31b5fa0b3248d9e78062
https://doi.org/10.1021/acs.jnatprod.1c00399

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Feature-Based Molecular Networking for the Targeted Identification of Gq-Inhibiting FR900359 Derivatives

Autor: Wiebke Hanke, Raphael Reher, Christa E. Müller, Evi Kostenis, Gabriele M. König, Jung Bong Kim, Stefan Kehraus, Max Crüsemann, Julian Patt, Judith Alenfelder, Vigneshwaran Namasivayam, Mitja M Zdouc, Goran Vuk Grujicic, Jan H. Voss

Publikováno v: Journal of Natural Products. 84:1941-1953

Both the soil bacterium Chromobacterium vaccinii and the bacterial endosymbiont Candidatus Burkholderia crenata of the plant Ardisia crenata are producers of FR900359 (FR). This cyclic depsipeptide is a potent and selective Gq protein inhibitor used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09ecc71cfc0a46eaf6adf701be381175
https://doi.org/10.1021/acs.jnatprod.1c00194

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Heterologous Expression in

Autor: Arnaud, Taton, Sebastian, Rohrer, Brienna, Diaz, Raphael, Reher, Andres Mauricio, Caraballo Rodriguez, Marsha L, Pierce, Pieter C, Dorrestein, Lena, Gerwick, William H, Gerwick, James W, Golden

Publikováno v: ACS chemical biology. 17(7)

Columbamides are chlorinated acyl amide natural products, several of which exhibit cannabinomimetic activity. These compounds were originally discovered from a culture of the filamentous marine cyanobacterium

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dde45b0798ea3ee635dbfb4ca4d5f869
https://pubmed.ncbi.nlm.nih.gov/35761435

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Systematic classification of unknown metabolites using high-resolution fragmentation mass spectra

Autor: Markus Fleischauer, Daniel Petras, Martin Hoffmann, William H. Gerwick, Pieter C. Dorrestein, Juho Rousu, Kai Dührkop, Marcus Ludwig, Sebastian Böcker, Louis-Félix Nothias, Raphael Reher

Publikováno v: Nature Biotechnology. 39:462-471

Metabolomics using nontargeted tandem mass spectrometry can detect thousands of molecules in a biological sample. However, structural molecule annotation is limited to structures present in libraries or databases, restricting analysis and interpretat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa19706337d285f094ed8addf277de3a
https://doi.org/10.1038/s41587-020-0740-8

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