Mathematical modeling of disease dynamics in SDHB- and SDHD-related paraganglioma: Further step in understanding hereditary tumor differences and future therapeutic strategies.

Autor: Dominique Barbolosi, Joakim Crona, Raphaël Serre, Karel Pacak, David Taieb

Publikováno v: PLoS ONE, Vol 13, Iss 8, p e0201303 (2018)

Succinate dehydrogenase subunit B and D (SDHB and SDHD) mutations represent the most frequent cause of hereditary pheochromocytoma and paraganglioma (PPGL). Although truncation of the succinate dehydrogenase complex is thought to be the disease causi

Externí odkaz: https://doaj.org/article/84c4829c51f2435fa28931c6aeffab04

Mathematical modeling of peripheral blood neutrophil kinetics to predict CLAD after lung transplantation

Autor: Laurent Papazian, Martine Reynaud-Gaubert, Jean-Baptiste Rey, Pascal Thomas, Charlotte Grosdidier, Elissa Cousin, Dominique Barbolosi, Françoise Dignat-George, Corinne Nicolino-Brunet, Benjamin Coiffard, Raphaël Serre

Publikováno v: Transplant Immunology
Transplant Immunology, Elsevier, 2020, 62, pp.101321. ⟨10.1016/j.trim.2020.101321⟩
Transplant Immunology, 2020, 62, pp.101321. ⟨10.1016/j.trim.2020.101321⟩

International audience; Background: The presence of neutrophils in the lung was identified as a factor associated with CLAD but requires invasive smples. The aim of this study was to assess the kinetics of peripheral blood neutrophils after lung tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0994814a982e80eb593a35ae32d3e34a
https://hal-amu.archives-ouvertes.fr/hal-03159574

Immunologically effective dose: a practical model for immuno-radiotherapy

Autor: Dominique Barbolosi, Xavier Muracciole, Raphaël Serre, Fabrice Barlesi

Publikováno v: Oncotarget

// Raphael Serre 1 , Fabrice Barlesi 2 , Xavier Muracciole 3 and Dominique Barbolosi 1 1 Simulation & Modelling Adaptive Response for Therapeutics in Cancer (SMARTc), Center for Research on Cancer of Marseille, CRCM Inserm UMR1068, CNRS UMR7258, Aix

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a16cea6f0d806fcfa9290f01105719d4
https://pubmed.ncbi.nlm.nih.gov/30159124

Model-driven metronomic vinorelbine in heavily pre-treated metastatic NSCLC and PM patients: Results of a phase I/II study

Autor: Matthieu Barbolosi, Sylvanie Bonnet, Dominique Barbolosi, Raphaël Serre, Laurent Greiller, Laure Deyme, Joseph Ciccolini, Diane-Charlotte Imbs, Bruno Lacarelle, Pascale Tomasini, Elissa Cousin, Melissa Galloux, Fabrice Barlesi

Publikováno v: Journal of Clinical Oncology. 37:e20505-e20505

e20505 Background: A phase I/II trial (NCT02555007) of oral metronomic Vinorelbine derived from a mathematical model was performed in heavily pretreated metastatic Non-Small Cell Lung Cancer or Pleural Mesothelioma patients. Progression free survival

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a16af526db56f87dd2bc7ca74930295d
https://doi.org/10.1200/jco.2019.37.15_suppl.e20505

Mathematical Modeling of Cancer Immunotherapy and Its Synergy with Radiotherapy

Autor: Raphaël Serre, Xavier Muracciole, Christophe Meille, Dominique Barbolosi, Sebastien Benzekry, Laetitia Padovani, Fabrice Barlesi, Joseph Ciccolini, Nicolas André

Publikováno v: Cancer Research
Cancer Research, American Association for Cancer Research, 2016, ⟨10.1158/0008-5472.CAN-15-3567⟩
Cancer Research, 2016, ⟨10.1158/0008-5472.CAN-15-3567⟩

Combining radiotherapy with immune checkpoint blockade may offer considerable therapeutic impact if the immunosuppressive nature of the tumor microenvironment (TME) can be relieved. In this study, we used mathematical models, which can illustrate the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5e47d25b139327aa32ca90297966cf
https://pubmed.ncbi.nlm.nih.gov/27302167