Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Raphaël Rahmani"'
Autor:
Damien R. Drew, Brian J. Smith, Raphaël Rahmani, Swapna Varghese, James G. Beeson, Jonathan B. Baell, Jake Baum
Publikováno v:
ChemMedChem. 16:679-693
Malarial parasites employ actin dynamics for motility, and any disruption to these dynamics renders the parasites unable to effectively establish infection. Therefore, actin presents a potential target for malarial drug discovery, and naturally occur
Autor:
Wessel A.C. Burger, Arthur Christopoulos, Jonathan B. Baell, Emma T van der Westhuizen, Geoff Thompson, Christopher J. Langmead, Celine Valant, Patrick R. Gentry, Kunio Hirata, Ziva Vuckovic, Raphaël Rahmani, Swapna Varghese, Patrick M. Sexton, David M. Thal, Alice E. Berizzi, Craig W. Lindsley, Andrew B. Tobin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The 5 subtypes of the muscarinic acetylcholine receptors (mAChRs) are expressed throughout the central and peripheral nervous system where they play a vital role in physiology and pathologies. Recently, the M5 mAChR subtype has emerged a
Autor:
Amanda G. Eufrasio, Stephanie Russell, Girdhar Singh Deora, Amy J. Jones, Artur T. Cordeiro, Swapna Varghese, Vicky M. Avery, Raphaël Rahmani, Matthew J. Piggott, Lori Ferrins, Arthur Toynton, Julian Sherman, Melissa Sykes, Ana Rodriguez, Albane Kessler, Jonathan B. Baell
Publikováno v:
ACS Med Chem Lett
[Image: see text] Trypanosoma brucei (T. brucei) and Trypanosoma cruzi (T. cruzi) are causative agents of parasitic diseases known as human African trypanosomiasis and Chagas disease, respectively. Together, these diseases affect 68 million people ar
Publikováno v:
RSC Med Chem
Trypanosoma cruzi and Trypanosoma brucei are the parasitic causative agents of Chagas disease and human African trypanosomiasis (HAT), respectively. The drugs currently used to treat these diseases are not efficacious against all stages and/or parasi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f1df8e8ec4f1efc7af58b1c878468c
https://europepmc.org/articles/PMC7578707/
https://europepmc.org/articles/PMC7578707/
Autor:
Luigi Aurelio, Sandeep Chhabra, Meghan Hattarki, Matthew L. Dennis, Bim Graham, James D. Swarbrick, Jonathan B. Baell, Ben Cleary, Jeremy Shonberg, Thomas S. Peat, Nicholas Barlow, Michael D. Lee, Zhong-Chang Wang, Noel P. Pitcher, Jitendra R. Harjani, Aaron DeBono, Olan Dolezal, Raphaël Rahmani, Mohamed H. Ahmed
Publikováno v:
Chemistry - A European Journal. 24:1922-1930
Dihydropteroate synthase (DHPS) is an enzyme of the folate biosynthesis pathway, which catalyzes the formation of 7,8-dihydropteroate (DHPt) from 6-hydroxymethyl-7,8-dihydropterin pyrophosphate (DHPPP) and para-aminobenzoic acid (pABA). DHPS is the l
Autor:
Christopher J. Tonkin, Melanie J. Williams, Jake Baum, Jonathan B. Baell, Brian J. Smith, Mark D. Wilkinson, Damien R. Drew, Johnny X. Huang, Yan Hong Tan, James G. Beeson, Swapna Johnson, Raphaël Rahmani
Publikováno v:
J Med Chem
Polymerization of the cytosolic protein actin is c ritical to cell movement and host-cell invasion by the malaria parasite, Plasmodium falciparum. Any disruption to actin polymerization dynamics will render the parasite in capable of invading a host
Autor:
Michelle Gazdik, Jonathan B. Baell, Marcel Kaiser, Amy J. Jones, Christel A. S. Bergström, Raphaël Rahmani, Susan A. Charman, Lori Ferrins, Karen L. White, Melissa Sykes, Eileen Ryan, Swapna Varghese, Vicky M. Avery
Publikováno v:
Journal of Medicinal Chemistry. 57:6393-6402
A whole-organism screen of approximately 87000 compounds against Trypanosoma brucei brucei identified a number of promising compounds for medicinal chemistry optimization. One of these classes of compounds we termed the pyridyl benzamides. While the
Autor:
Virginie Héran, Raphaël Rahmani, Béatrice Tuccio, Laurent Commeiras, Jean-Luc Parrain, Yannick Carissan, Romain Blanc, Jean Drujon
Publikováno v:
Physical Chemistry Chemical Physics
Physical Chemistry Chemical Physics, Royal Society of Chemistry, 2014, 16, pp.7513-7520. ⟨10.1039/c3cp55077j⟩
Physical Chemistry Chemical Physics, 2014, 16, pp.7513-7520. ⟨10.1039/c3cp55077j⟩
Physical Chemistry Chemical Physics, Royal Society of Chemistry, 2014, 16, pp.7513-7520. ⟨10.1039/c3cp55077j⟩
Physical Chemistry Chemical Physics, 2014, 16, pp.7513-7520. ⟨10.1039/c3cp55077j⟩
International audience; The auto-oxidation of trans-1,2-disiloxybenzocyclobutene was found to be very efficient, giving endoperoxide in quantitative yield. Each step of the mechanism of spin-forbidden addition of triplet oxygen O2 was studied by both
Autor:
Albert C. Pan, Celine Valant, Arthur Christopoulos, James R. Valcourt, Hillary F. Green, Raphaël Rahmani, Patrick M. Sexton, David E. Shaw, Jonathan B. Baell, Daniel H. Arlow, Meritxell Canals, Ron O. Dror, David W. Borhani, J. Robert Lane
Publikováno v:
Nature. 503:295-299
Binding modes and molecular mechanisms of several allosteric modulators of a prototypical G-protein-coupled receptor are revealed using atomic-level simulations and validated by the rational design of a modulator with substantially altered effects. A
Autor:
Amy J. Jones, Katherine M. Ellis, Jennifer Riley, Malcolm J. McConville, Vicky M. Avery, Daniel Stoessel, Cameron J. Nowell, Raphaël Rahmani, Lori Ferrins, Kevin D. Read, Jonathan B. Baell, Darren J. Creek
Publikováno v:
Metabolomics. 12
Trypanosoma brucei is the causative agent of human African trypanosomiasis, which is responsible for thousands of deaths every year. Current therapies are limited and there is an urgent need to develop new drugs. The anti-trypanosomal compound, 3-(ox