Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Raphaël Leman"'
Autor:
Lucie Thorel, Jordane Divoux, Justine Lequesne, Guillaume Babin, Pierre-Marie Morice, Romane Florent, Guillaume Desmartin, Lucie Lecouflet, Chloé Marde Alagama, Alexandra Leconte, Bénédicte Clarisse, Mélanie Briand, Roman Rouzier, Léopold Gaichies, Sandrine Martin-Françoise, Jean-François Le Brun, Christophe Denoyelle, Nicolas Vigneron, Corinne Jeanne, Cécile Blanc-Fournier, Raphaël Leman, Dominique Vaur, Martin Figeac, Matthieu Meryet-Figuiere, Florence Joly, Louis-Bastien Weiswald, Laurent Poulain, Enora Dolivet
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Background Ovarian cancer is the first cause of death from gynecological malignancies mainly due to development of chemoresistance. Despite the emergence of PARP inhibitors, which have revolutionized the therapeutic management of some of the
Externí odkaz:
https://doaj.org/article/088b590c02d14c37987eaddfddc2217f
Autor:
Antoine Gilbert, Mihaela Tudor, Amandine Delaunay, Raphaël Leman, Julien Levilly, Alexandre Atkinson, Laurent Castéra, Anca Dinischiotu, Diana Iulia Savu, Samuel Valable, François Chevalier
Publikováno v:
Biomolecules, Vol 14, Iss 9, p 1071 (2024)
Chondrosarcoma is a rare malignant tumor that forms in bone and cartilage. The primary treatment involves surgical removal of the tumor with a margin of healthy tissue. Especially if complete surgical removal is not possible, radiation therapy and ch
Externí odkaz:
https://doaj.org/article/ea03a70df7ab485dbde011ce8e1c3eff
Autor:
Elodie Coquan, Nicolas Penel, Justine Lequesne, Raphaël Leman, Pernelle Lavaud, Zoé Neviere, Pierre-Emmanuel Brachet, Emeline Meriaux, Aurélien Carnot, Jérémy Boutrois, Marie Castera, Nicolas Goardon, Etienne Muller, Alexandra Leconte, Antoine Thiery-Vuillemin, Bénédicte Clarisse, Florence Joly
Publikováno v:
Therapeutic Advances in Urology, Vol 16 (2024)
Introduction: DNA damage repair genes are altered in 20–35% of metastatic castration-resistant prostate cancer (mCRPC). Poly-ADP (Adénosine Diphosphate)-ribose polymerase inhibitors (PARPi) showed significant activity for these selected tumors, es
Externí odkaz:
https://doaj.org/article/5a69b905bc4946d5bd1a26e1aca0aa30
Autor:
Raphaël Leman, Hélène Tubeuf, Sabine Raad, Isabelle Tournier, Céline Derambure, Raphaël Lanos, Pascaline Gaildrat, Gaia Castelain, Julie Hauchard, Audrey Killian, Stéphanie Baert-Desurmont, Angelina Legros, Nicolas Goardon, Céline Quesnelle, Agathe Ricou, Laurent Castera, Dominique Vaur, Gérald Le Gac, Chandran Ka, Yann Fichou, Françoise Bonnet-Dorion, Nicolas Sevenet, Marine Guillaud-Bataille, Nadia Boutry-Kryza, Inès Schultz, Virginie Caux-Moncoutier, Maria Rossing, Logan C. Walker, Amanda B. Spurdle, Claude Houdayer, Alexandra Martins, Sophie Krieger
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-12 (2020)
Abstract Background Branch points (BPs) map within short motifs upstream of acceptor splice sites (3’ss) and are essential for splicing of pre-mature mRNA. Several BP-dedicated bioinformatics tools, including HSF, SVM-BPfinder, BPP, Branchpointer,
Externí odkaz:
https://doaj.org/article/da6b4502084e4b2a87009788da78c331
Autor:
Raphaël Leman, Étienne Muller, Nicolas Goardon, Imène Chentli, Aurore Tranchant, Angelina Legros, Laurent Castera, Florence Joly, Alain Morel, Christel Brunet, Véronique Bocly, Éric Fernandez, Florence Coulet, Roseline Tang, Étienne Rouleau, Florine Oca, Romain Boucly, Aurélie Dumont, Catherine Genestie, Hans-Joachim Lück, Piera Gargiulo, Diana Bello Roufai, Marie-Ange Mouret-Reynier, Hugues Bourgeois, Anne-Claire Hardy-Bessard, Christine Montoto, Isabelle Ray-Coquard, Éric Pujade-Lauraine, Dominique Vaur
Publikováno v:
Innovations & Thérapeutiques en Oncologie. 9:31-34
Autor:
Camille Aucouturier, Nicolas Soirat, Laurent Castéra, Denis Bertrand, Alexandre Atkinson, Thibaut Lavolé, Nicolas Goardon, Céline Quesnelle, Julien Levilly, Sosthène Barbachou, Angelina Legros, Olivier Caron, Louise Crivelli, Philippe Denizeau, Pascaline Berthet, Agathe Ricou, Flavie Boulouard, Dominique Vaur, Sophie Krieger, Raphael Leman
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract Background Solving the structure of mRNA transcripts is a major challenge for both research and molecular diagnostic purposes. Current approaches based on short-read RNA sequencing and RT-PCR techniques cannot fully explore the complexity of
Externí odkaz:
https://doaj.org/article/a050435307744b7baf273c3a085e00d7
Autor:
Raphaël Leman, Béatrice Parfait, Dominique Vidaud, Emmanuelle Girodon, Laurence Pacot, Gérald Le Gac, Chandran Ka, Claude Ferec, Yann Fichou, Céline Quesnelle, Camille Aucouturier, Etienne Muller, Dominique Vaur, Laurent Castera, Flavie Boulouard, Agathe Ricou, Hélène Tubeuf, Omar Soukarieh, Pascaline Gaildrat, Florence Riant, Marine Guillaud‐Bataille, Sandrine M. Caputo, Virginie Caux‐Moncoutier, Nadia Boutry‐Kryza, Françoise Bonnet‐Dorion, Ines Schultz, Maria Rossing, Olivier Quenez, Louis Goldenberg, Valentin Harter, Michael T. Parsons, Amanda B. Spurdle, Thierry Frébourg, Alexandra Martins, Claude Houdayer, Sophie Krieger
Publikováno v:
Leman, R, Parfait, B, Vidaud, D, Girodon, E, Pacot, L, Le Gac, G, Ka, C, Ferec, C, Fichou, Y, Quesnelle, C, Aucouturier, C, Muller, E, Vaur, D, Castera, L, Boulouard, F, Ricou, A, Tubeuf, H, Soukarieh, O, Gaildrat, P, Riant, F, Guillaud-Bataille, M, Caputo, S M, Caux-Moncoutier, V, Boutry-Kryza, N, Bonnet-Dorion, F, Schultz, I, Rossing, M, Quenez, O, Goldenberg, L, Harter, V, Parsons, M T, Spurdle, A B, Frébourg, T, Martins, A, Houdayer, C & Krieger, S 2022, ' SPiP : Splicing Prediction Pipeline, a machine learning tool for massive detection of exonic and intronic variant effects on mRNA splicing ', Human Mutation, vol. 43, no. 12, pp. 2308-2323 . https://doi.org/10.1002/humu.24491
Modeling splicing is essential for tackling the challenge of variant interpretation as each nucleotide variation can be pathogenic by affecting pre-mRNA splicing via disruption/creation of splicing motifs such as 5’/3’ splice sites, branch sites
Autor:
Raphaël Leman, Etienne Muller, Nicolas Goardon, Imène Chentli, Aurore Tranchant, Angelina Legros, Laurent Castera, Alain Morel, Christel Brunet, Véronique Bocly, Eric Fernandez, Florence Coulet, Catherine Genestie, Hans-Joachim Lück, Piera Gargiulo, Antonio González-Martin, Christoph Grimm, Isabelle Ray-Coquard, Eric Pujade-Lauraine, Dominique Vaur
Publikováno v:
Ovarian cancer.
Akademický článek
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Autor:
Gérald Le Gac, Alexandra Martins, Pascaline Gaildrat, Florence Coulet, Françoise Revillon, Antoine Rousselin, Sandrine M. Caputo, Marine Guillaud-Bataille, Chandran Ka, Mélanie Léoné, Nadia Boutry-Kryza, Virginie Caux-Moncoutier, Claude Férec, Capucine Delnatte, Danielle Muller, Grégoire Davy, Amanda B. Spurdle, Maria Rossing, Raphaël Leman, Yann Fichou, Michael T. Parsons, Barbara Wappenschmidt, Violaine Bourdon, Joanna Sokolowska, Nicolas Sevenet, Claude Houdayer, M.-P. Audrézet, Brigitte Bressac-de Paillerets, Françoise Bonnet-Dorion, Sylvie Mazoyer, Gaia Castelain, Sophie Krieger, Laurent Castera, Etienne Rouleau
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 2018, 46 (15), pp.7913-7923. ⟨10.1093/nar/gky372⟩
Nucleic Acids Research, Oxford University Press, 2018, 46 (15), pp.7913-7923. ⟨10.1093/nar/gky372⟩
Nucleic Acids Research, 2018, 46 (15), pp.7913-7923. ⟨10.1093/nar/gky372⟩
Nucleic Acids Research, Oxford University Press, 2018, 46 (15), pp.7913-7923. ⟨10.1093/nar/gky372⟩
Variant interpretation is the key issue in molecular diagnosis. Spliceogenic variants exemplify this issue as each nucleotide variant can be deleterious via disruption or creation of splice site consensus sequences. Consequently, reliable in silico p