Novel PD-L1-Targeted Phenyl-Pyrazolone Derivatives with Antioxidant Properties

Autor: Romain Regnault, Frédérique Klupsch, Hassiba El-Bouazzati, Romain Magnez, Raphaël Le Biannic, Natascha Leleu-Chavain, Hania Ahouari, Hervé Vezin, Régis Millet, Jean-François Goossens, Xavier Thuru, Christian Bailly

Publikováno v: Molecules, Vol 28, Iss 8, p 3491 (2023)

Orally-active anticancer small molecules targeting the PD-1/PD-L1 immune checkpoint are actively searched. Phenyl-pyrazolone derivatives with a high affinity for PD-L1 have been designed and characterized. In addition, the phenyl-pyrazolone unit acts

Externí odkaz: https://doaj.org/article/e4b8fd713f14437dbeba68169e10a2a0

Pyrazolones as inhibitors of immune checkpoint blocking the PD-1/PD-L1 interaction

Autor: Raphaël Le Biannic, Romain Magnez, Frédérique Klupsch, Natascha Leleu-Chavain, Bryan Thiroux, Morgane Tardy, Hassiba El Bouazzati, Xavier Dezitter, Nicolas Renault, Gérard Vergoten, Christian Bailly, Bruno Quesnel, Xavier Thuru, Régis Millet

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2022, 236, pp.114343. ⟨10.1016/j.ejmech.2022.114343⟩

Immuno-therapy has become a leading strategy to fight cancer. Over the past few years, immuno-therapies using checkpoint inhibitor monoclonal antibodies (mAbs) against programmed death receptor 1 (PD-1) and programmed death ligand 1 (PD-L1) have demo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab833e33558bab0547d52ecf4719d73
https://hal.science/hal-03641793