Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Raphaël Labruère"'
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Nanoparticle-based antibiotic constructs have become a popular area of investigation in the biomedical sciences. Much of this work has pertained to human diseases, largely in the cancer therapy arena. However, considerable research has also been devo
Externí odkaz:
https://doaj.org/article/9ced1d0860284799a1de41aa122d3d11
Publikováno v:
Phytochemistry Letters. 54:146-152
Autor:
Charles Skarbek, Hichem Maslah, Marie-Aude Plamont, Stéphanie Pethe, Catherine Gourson, Thomas Le Saux, Ludovic Jullien, Raphaël Labruère
Publikováno v:
Angewandte Chemie. 133:24245-24249
Pharmacological inactivation of antitumor drugs toward healthy cells is a critical factor in prodrug development. Typically, pharmaceutical chemists graft temporary moieties to existing antitumor drugs to reduce their pharmacological activity as much
Autor:
Anaïs Espinosa, Estelle Rascol, Marta Abellán Flos, Charles Skarbek, Pascale Lieben, Eva Bannerman, Alba Diez Martinez, Stéphanie Pethe, Pierre Benoit, Sylvie Nélieu, Raphaël Labruère
Publikováno v:
Chemosphere. 306:135616
Environmental emission of pharmaceutical pollutants notably causes the contamination of aquatic ecosystems and drinking water. Typically, reduction of these pollutants in the environment is mostly managed by ameliorated wastewater treatments. Here, w
Publikováno v:
Future medicinal chemistry. 13(10)
Autor:
Charles Skarbek, Anaïs Espinosa, Sylvie Nélieu, Pascale Lieben, Pierre Benoit, Raphaël Labruère
Publikováno v:
Environmental Science and Pollution Research
Environmental Science and Pollution Research, Springer Verlag, In press, ⟨10.1007/s11356-021-15820-3⟩
Environmental Science and Pollution Research, Springer Verlag, In press, ⟨10.1007/s11356-021-15820-3⟩
Methotrexate is an antineoplastic folate analog of high environmental concern, due to its low biodegradability and toxicological properties. This study focused on its photodegradation under two irradiation conditions, aiming to be representative of e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10324722e8544ca009daa2f3469bd924
https://hal.inrae.fr/hal-03355435
https://hal.inrae.fr/hal-03355435
Autor:
Raphaël Labruère, Philippe M. Loiseau, Stéphanie Pethe, Elodie Jagu, Sébastien Pomel, Alba Diez-Martinez, Estelle Rascol
Publikováno v:
European Journal of Medicinal Chemistry. 150:655-666
This study describes the synthesis and the biological evaluation of twenty-four original bis(benzyl)spermidines. Structural modifications of the polyamine scaffold were performed in order to avoid easily metabolized bonds. Some bis(benzyl)polyamine d
Autor:
Charles Skarbek, Thi Hang Au, Thi Thu Ha Vu, Stéphanie Pethe, Giang Vo-Thanh, Thi Phuong Hoa Nguyen, Raphaël Labruère, Jean-Pierre Baltaze
Publikováno v:
Tetrahedron. 92:132248
The Michael addition reaction of amines, phosphonates and thiols to Tagitinin C containing in its structure an α-methylene-γ-lactone motif and two α,β-unsaturated ketone systems has been described. 27 Tagitinin C derivatives were synthesized and
Publikováno v:
European Journal of Medicinal Chemistry. 139:982-1015
Naturally occurring polyamines: putrescine, spermidine and spermine are crucial for Kinetoplastid growth and persistence. These aliphatic polycations are either biosynthesized or internalized into Kinetoplastid by active transport. Impairing the poly
Publikováno v:
Bioorganic Chemistry
Bioorganic Chemistry, Elsevier, 2019, 91, pp.103158-. ⟨10.1016/j.bioorg.2019.103158⟩
Bioorganic Chemistry, Elsevier, 2019, 91, pp.103158-. ⟨10.1016/j.bioorg.2019.103158⟩
This study describes the synthesis of arylboronate-based ROS-responsive prodrugs of doxorubicin and their biological evaluation as anticancer agents. The determination of the most sensitive cancer type toward arylboronate prodrugs is crucial for furt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::460a7e8db8d459a8a05648e92b064b00
https://hal.archives-ouvertes.fr/hal-03487225/file/S0045206819309381.pdf
https://hal.archives-ouvertes.fr/hal-03487225/file/S0045206819309381.pdf