Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Raphaël Frédérick"'
Autor:
Luc Pilotte, Benoit J Van den Eynde, Jingjing Zhu, Christine Sers, Marie Solvay, Pauline Holfelder, Simon Klaessens, Vincent Stroobant, Juliette Lamy, Stefan Naulaerts, Quentin Spillier, Raphaël Frédérick, Etienne De Plaen, Christiane A Opitz
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 6 (2023)
Background Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan-dioxygenase (TDO) are enzymes catabolizing the essential amino acid tryptophan into kynurenine. Expression of these enzymes is frequently observed in advanced-stage cancers and is associa
Externí odkaz:
https://doaj.org/article/8b5d6705c624408ca6c9425808c1b3f5
Autor:
Luca X. Zampieri, Martina Sboarina, Andrea Cacace, Debora Grasso, Léopold Thabault, Loïc Hamelin, Thibaut Vazeille, Elodie Dumon, Rodrigue Rossignol, Raphaël Frédérick, Etienne Sonveaux, Florence Lefranc, Pierre Sonveaux
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11938 (2021)
Glioblastoma represents the highest grade of brain tumors. Despite maximal resection surgery associated with radiotherapy and concomitant followed by adjuvant chemotherapy with temozolomide (TMZ), patients have a very poor prognosis due to the rapid
Externí odkaz:
https://doaj.org/article/666aff1d5374431b9cb3e655cb392174
Autor:
Quentin Spillier, Séverine Ravez, Simon Dochain, Didier Vertommen, Léopold Thabault, Olivier Feron, Raphaël Frédérick
Publikováno v:
Molecules, Vol 26, Iss 2, p 477 (2021)
The serine biosynthetic pathway is a key element contributing to tumor proliferation. In recent years, targeting of phosphoglycerate dehydrogenase (PHGDH), the first enzyme of this pathway, intensified and revealed to be a promising strategy to devel
Externí odkaz:
https://doaj.org/article/397fdc8286c44ecab44d04acdbe41aea
Autor:
Quentin Spillier, Séverine Ravez, Judith Unterlass, Cyril Corbet, Charline Degavre, Olivier Feron, Raphaël Frédérick
Publikováno v:
Pharmaceuticals, Vol 13, Iss 2, p 20 (2020)
For many years now, targeting deregulation within cancer cells’ metabolism has appeared as a promising strategy for the development of more specific and efficient cancer treatments. Recently, numerous reports highlighted the crucial role of the ser
Externí odkaz:
https://doaj.org/article/9c98f002cc4a4f8fae8c764f82e6ce92
Autor:
Audrey M Neyrinck, Barbara Pachikian, Bernard Taminiau, Georges Daube, Raphaël Frédérick, Patrice D Cani, Laure B Bindels, Nathalie M Delzenne
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160488 (2016)
Inulin-type fructans (ITF) are known for their capacity to modulate gut microbiota, energy metabolism and to improve glycemia in several animal models of obesity, and in humans. The potential contribution of ITF as modulators of sugar digestion by ho
Externí odkaz:
https://doaj.org/article/c995ca9289514e04817861e7d6c483f7
Publikováno v:
Pharmaceuticals, Vol 10, Iss 4, p 94 (2017)
The “Journées Franco-Belges de Pharmacochimie” is a recognized two-day annual meeting on Medicinal Chemistry that is renowned for the advanced science presented, conviviality, and outstanding opportunities for senior and young scientists to exch
Externí odkaz:
https://doaj.org/article/64bc4e5b81a0477d86549092bc3291c2
Autor:
Neha Shrestha, Yining Xu, Julien R.C. Prévost, Fiona McCartney, David Brayden, Raphaël Frédérick, Ana Beloqui, Véronique Préat
Publikováno v:
Acta biomaterialia, Vol. 140, p. 561-572 (2022)
Nanoparticle-based oral drug delivery systems have the potential to target inflamed regions in the gastrointestinal tract by specifically accumulating at disrupted colonic epithelium. But, delivery of intact protein drugs at the targeted site is a ma
Autor:
Marie Solvay, Pauline Pfänder, Simon Klaessens, Luc Pilotte, Vincent Stroobant, Juliette Lamy, Stefan Naulaerts, Quentin Spillier, Raphaël Frédérick, Etienne De Plaen, Christine Sers, Christiane A. Opitz, Benoit J. Van den Eynde, Jing-Jing Zhu
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol. 11, no. 6, p. e006728 (2023)
BackgroundIndoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan-dioxygenase (TDO) are enzymes catabolizing the essential amino acid tryptophan into kynurenine. Expression of these enzymes is frequently observed in advanced-stage cancers and is associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb910b1a5937411c7ca8b70616f19263
https://hdl.handle.net/2078.1/275939
https://hdl.handle.net/2078.1/275939
Autor:
Yonghua Tan, Marine Lefevre, François Pierrard, Mathieu Soetens, Maria Shoueiry, Esra Yildiz, Sébastien Ibanez, Kubra Ozkan, Olivier Feron, Raphaël Frédérick, Olivier Riant
Publikováno v:
Journal of Organometallic Chemistry, Vol. 996, no.-, p. 122743 (2023)
The palladium-catalyzed uncaging of alloc-protected amines in living cells has been extensively stud- ied mostly in the form of nanostructures or mesostructures. However, the scarcity of kinetic and mechanistic studies of discrete palladium complexes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30582f8e44e7b0c7261f9d009883b1d2
https://hdl.handle.net/2078.1/275937
https://hdl.handle.net/2078.1/275937
Autor:
Romain Marteau, Séverine Ravez, Darius Mazhari Dorooee, Hind Bouchaoui, Karine Porte, Jean-Christophe Devedjian, Patricia Melnyk, David Devos, Raphaël Frédérick, Jamal El Bakali
Publikováno v:
Biochemical pharmacology. 204
Ferroptosis, first coined in 2012, is an iron-dependent regulated cell death (RCD) characterized by the accumulation of lipid peroxides to toxic levels. This mechanism is currently being evaluated as a target for a variety of diseases offering new op