A blood-based biomarker panel (NIS4) for non-invasive diagnosis of non-alcoholic steatohepatitis and liver fibrosis: a prospective derivation and global validation study

Autor: Pierre Bedossa, Rémy Hanf, John Brozek, Quentin M. Anstee, G. Cordonnier, Yacine Hajji, Pierre Chaumat, Raphaël Darteil, Jérôme Boursier, Dam Noémie, S. Megnien, Roman Liebe, Suneil Hosmane, Jérémy Magnanensi, Stephen A. Harrison, A. Roudot, Bart Staels, Vlad Ratziu, Dean W. Hum, Sven Francque, Arun J. Sanyal, Zouher Majd, Fouad Ben Sudrik

Publikováno v: The Lancet Gastroenterology and Hepatology
The Lancet Gastroenterology and Hepatology, Elsevier, 2020, 5 (11), pp.970-985. ⟨10.1016/S2468-1253(20)30252-1⟩
Lancet gastroenterology & hepatology

Summary Background Non-invasive tests that can identify patients with non-alcoholic steatohepatitis (NASH) at higher risk of disease progression are lacking. We report the development and validation of a blood-based diagnostic test to non-invasively

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9284a623f20f102f986641604e354e6
https://hal.univ-angers.fr/hal-03284308

Characterization of EYP001 a novel, potent and selective FXR agonist in in vitro 3D human liver models of NASH

Autor: Pauline Radreau - Pierini, Stéphane Joly, Jacky Vonderscher, Pietro Scalfaro, Meldrum Eric, Raphaël Darteil

Publikováno v: Journal of Hepatology. 73:S453

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99543317602020039b9b3ae5b7f79798
https://doi.org/10.1016/s0168-8278(20)31388-x

Phosphorylation of Farnesoid X Receptor by Protein Kinase C Promotes Its Transcriptional Activity

Autor: Jean-Charles Fruchart, Bart Staels, Alexis Aquilina, Stéphane Helleboid, Romain Gineste, Dean W. Hum, Réjane Paumelle, Raphaël Darteil, Audrey Sirvent

Publikováno v: Molecular Endocrinology. 22:2433-2447

The farnesoid X receptor (FXR, NR1H4) belongs to the nuclear receptor superfamily and is activated by bile acids such as chenodeoxycholic acid, or synthetic ligands such as GW4064. FXR is implicated in the regulation of bile acid, lipid, and carbohyd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04dee19600b30c714c45b0c9ac26d3d9
https://doi.org/10.1210/me.2008-0092

Farnesoid X receptor represses hepatic lipase gene expression

Autor: Bart Staels, Raphaël Darteil, Hans Jansen, V. A. Kosykh, Audrey Sirvent, Jean-Charles Fruchart, Adrie J.M. Verhoeven, Dean W. Hum

Publikováno v: Journal of Lipid Research, Vol 45, Iss 11, Pp 2110-2115 (2004)
Journal of Lipid Research, 45(11), 2110-2115. American Society for Biochemistry and Molecular Biology Inc.

The farnesoid X receptor (FXR) is a nuclear receptor that regulates gene expression in response to bile acids (BAs). FXR plays a central role in BA, cholesterol, and lipoprotein metabolism. Here, we identify HL, an enzyme involved in the metabolism o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f810e2f90a102ca781174bc97b5a6e46
https://pure.eur.nl/en/publications/229a57eb-de91-4646-ab0d-250fc30c1d71

High-Level Protein Secretion into Blood Circulation after Electric Pulse-Mediated Gene Transfer into Skeletal Muscle

Autor: Florence Emmanuel, Abderrahim Mahfoudi, Daniel Scherman, Pia Delaère, Mickaël Bettan, Didier Branelec, Fabienne Soubrier, Jean-Michel Caillaud, Nicolas Duverger, Raphaël Darteil

Publikováno v: Molecular Therapy. 2:204-210

Numerous diseases are linked to the absence or insufficient concentration of a specific plasma protein. Gene transfer is an appealing strategy for correction of such diseases. We report high and sustained plasma secretion of human secreted alkaline p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6adf07b4d4a868c0cd68e15e66826e09
https://doi.org/10.1006/mthe.2000.0117