Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Raphaël Bolteau"'
Autor:
Amélie Laversin, Robin Dufossez, Raphaël Bolteau, Romain Duroux, Séverine Ravez, Sergio Hernandez-Tapia, Martin Fossart, Mathilde Coevoet, Maxime Liberelle, Saïd Yous, Nicolas Lebègue, Patricia Melnyk
Publikováno v:
Molecules, Vol 29, Iss 16, p 3847 (2024)
The adenosine A2A receptor (A2AR) has been identified as a therapeutic target for treating neurodegenerative diseases and cancer. In recent years, we have highlighted the 2-aminoquinazoline heterocycle as an promising scaffold for designing new A2AR
Externí odkaz:
https://doaj.org/article/a703fdddfb0a4440a94b3374b1f753d3
Autor:
Raphaël, Bolteau, Romain, Duroux, Amélie, Laversin, Brandon, Vreulz, Anna, Shiriaeva, Benjamin, Stauch, Gye Won, Han, Vadim, Cherezov, Nicolas, Renault, Amélie, Barczyk, Séverine, Ravez, Mathilde, Coevoet, Patricia, Melnyk, Maxime, Liberelle, Saïd, Yous
Publikováno v:
European journal of medicinal chemistry. 241
The past fifty years have been marked by the surge of neurodegenerative diseases. Unfortunately, current treatments are only symptomatic. Hence, the search for new and innovative therapeutic targets for curative treatments becomes a major challenge.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9dbcd2e0b44d5188113542cf70cf8484
https://pubmed.ncbi.nlm.nih.gov/35933788
https://pubmed.ncbi.nlm.nih.gov/35933788
Quinazoline and phthalazine derivatives as novel melatonin receptor ligands analogues of agomelatine
Autor:
Philippe Delagrange, Patricia Melnyk, Daniel Henri Caignard, Raphaël Bolteau, Florian Descamps, Mohamed Ettaoussi, Saïd Yous
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2020, 189, pp.112078-. ⟨10.1016/j.ejmech.2020.112078⟩
European Journal of Medicinal Chemistry, 2020, 189, pp.112078. ⟨10.1016/j.ejmech.2020.112078⟩
European Journal of Medicinal Chemistry, Elsevier, 2020, 189, pp.112078-. ⟨10.1016/j.ejmech.2020.112078⟩
European Journal of Medicinal Chemistry, 2020, 189, pp.112078. ⟨10.1016/j.ejmech.2020.112078⟩
International audience; For further development of successors of Agomelatine through modulation of its pharmacokinetic properties, we report herein the design, synthesis and pharmacological results of a new family of melatonin receptor ligands. Issue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a119ad2a16d626226293a69a1dfb0ef
https://hal.archives-ouvertes.fr/hal-03489716
https://hal.archives-ouvertes.fr/hal-03489716
Autor:
Nicolas Renault, Raphaël Bolteau, Laurence Agouridas, Romain Duroux, Rajaa Boulahjar, Angela Rincon Arias, Amélie Barczyk, Patricia Melnyk, Saïd Yous, Mathilde Coevoet
Publikováno v:
Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, Elsevier, 2018, 26 (12), pp.3296-3307. ⟨10.1016/j.bmc.2018.04.057⟩
Bioorganic and Medicinal Chemistry, 2018, 26 (12), pp.3296-3307. ⟨10.1016/j.bmc.2018.04.057⟩
Bioorganic and Medicinal Chemistry, Elsevier, 2018, 26 (12), pp.3296-3307. ⟨10.1016/j.bmc.2018.04.057⟩
Bioorganic and Medicinal Chemistry, 2018, 26 (12), pp.3296-3307. ⟨10.1016/j.bmc.2018.04.057⟩
International audience; Imidazo[1,2a]pyridines have gained much interest in the field of medicinal chemistry research. In the aim of accessing new privileged structure, we decided to design and synthesize 8-aminated-imidazo[1,2a]pyridines substituted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab0d188f1ef59d2a62136f9ff88409a
https://hal.archives-ouvertes.fr/hal-02060656
https://hal.archives-ouvertes.fr/hal-02060656